JP7254018B2 - ワクチンベクターとしての三セグメントピチンデウイルス - Google Patents

ワクチンベクターとしての三セグメントピチンデウイルス Download PDF

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JP7254018B2
JP7254018B2 JP2019513483A JP2019513483A JP7254018B2 JP 7254018 B2 JP7254018 B2 JP 7254018B2 JP 2019513483 A JP2019513483 A JP 2019513483A JP 2019513483 A JP2019513483 A JP 2019513483A JP 7254018 B2 JP7254018 B2 JP 7254018B2
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pithindevirus
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JP2019516410A5 (enExample
JP2019516410A (ja
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ボニーラ ウェルディ
デビッド ピンスチェワー ダニエル
オルリンジャー クラウス
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ユニベルシタト バーゼル
ホオキパ バイオテック ジーエムビーエイチ
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/06—Quantitative determination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/10011—Arenaviridae
    • C12N2760/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/10011—Arenaviridae
    • C12N2760/10023—Virus like particles [VLP]
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/10011—Arenaviridae
    • C12N2760/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/10011—Arenaviridae
    • C12N2760/10041—Use of virus, viral particle or viral elements as a vector
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/10011—Arenaviridae
    • C12N2760/10051—Methods of production or purification of viral material
    • C12N2760/10052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

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  • Analytical Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2019513483A 2016-05-18 2017-05-17 ワクチンベクターとしての三セグメントピチンデウイルス Active JP7254018B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022161464A JP7547433B2 (ja) 2016-05-18 2022-10-06 ワクチンベクターとしての三セグメントピチンデウイルス
JP2024146333A JP2024170461A (ja) 2016-05-18 2024-08-28 ワクチンベクターとしての三セグメントピチンデウイルス

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Application Number Priority Date Filing Date Title
US201662338400P 2016-05-18 2016-05-18
US62/338,400 2016-05-18
PCT/EP2017/061865 WO2017198726A1 (en) 2016-05-18 2017-05-17 Tri-segmented pichinde viruses as vaccine vectors

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JP2019516410A JP2019516410A (ja) 2019-06-20
JP2019516410A5 JP2019516410A5 (enExample) 2020-07-02
JP7254018B2 true JP7254018B2 (ja) 2023-04-07

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JP2022161464A Active JP7547433B2 (ja) 2016-05-18 2022-10-06 ワクチンベクターとしての三セグメントピチンデウイルス
JP2024146333A Pending JP2024170461A (ja) 2016-05-18 2024-08-28 ワクチンベクターとしての三セグメントピチンデウイルス

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JP2024146333A Pending JP2024170461A (ja) 2016-05-18 2024-08-28 ワクチンベクターとしての三セグメントピチンデウイルス

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US (2) US20190135875A1 (enExample)
EP (1) EP3458593A1 (enExample)
JP (3) JP7254018B2 (enExample)
KR (2) KR102671785B1 (enExample)
CN (2) CN117486979A (enExample)
AU (2) AU2017266738B2 (enExample)
BR (1) BR112018073794A2 (enExample)
CA (1) CA3023599A1 (enExample)
EA (1) EA201892648A1 (enExample)
IL (2) IL262963B2 (enExample)
MX (2) MX2018013956A (enExample)
NZ (2) NZ788311A (enExample)
SG (1) SG11201810048VA (enExample)
WO (1) WO2017198726A1 (enExample)

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US10722564B2 (en) 2014-11-13 2020-07-28 Université de Genéve Tri-segmented arenaviruses as vaccine vectors
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EP3960197A1 (en) 2015-11-12 2022-03-02 Hookipa Biotech GmbH Arenavirus particles as cancer vaccines
CN110719788A (zh) * 2017-04-07 2020-01-21 霍欧奇帕生物科技有限公司 治疗实体瘤的沙粒病毒颗粒
US10870691B2 (en) 2018-04-05 2020-12-22 Gilead Sciences, Inc. Antibodies and fragments thereof that bind hepatitis B virus protein X
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EP3999107A1 (en) 2019-07-16 2022-05-25 Gilead Sciences, Inc. Hiv vaccines and methods of making and using
EP4458975A3 (en) 2019-09-30 2025-02-12 Gilead Sciences, Inc. Hbv vaccines and methods treating hbv
EP4055173A1 (en) 2019-11-07 2022-09-14 Universität Basel Vizerektorat Forschung Arenaviruses as vectors
EP4069729B1 (en) 2019-12-06 2025-01-22 Precision BioSciences, Inc. Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome
MX2022007930A (es) 2019-12-24 2022-08-08 Carna Biosciences Inc Compuestos moduladores de diacilglicerol quinasa.
AR121620A1 (es) 2020-03-20 2022-06-22 Gilead Sciences Inc Profármacos de nucleósidos 4’-c-sustituidos-2-halo-2’-deoxiadenosina y métodos de preparación y uso de los mismos
EP4157342A1 (en) 2020-05-29 2023-04-05 Hookipa Biotech GmbH Cancer treatment strategies using arenavirus vectors
US12053517B2 (en) 2021-01-14 2024-08-06 Gilead Sciences, Inc. HIV vaccines and methods of using
BR112023019365A2 (pt) 2021-03-23 2023-12-26 Hookipa Biotech Gmbh Segmento s de arenavírus, cdna, vetor de expressão de dna, célula hospedeira, partícula de arenavírus trissegmentada, método para gerar uma partícula de arenavírus trissegmentada, composição farmacêutica, método para tratar câncer de próstata e kit
WO2022238546A1 (en) 2021-05-13 2022-11-17 Hookipa Biotech Gmbh Arenaviruses as vectors
AU2022274607A1 (en) 2021-05-13 2023-11-16 Gilead Sciences, Inc. COMBINATION OF A TLR8 MODULATING COMPOUND AND ANTI-HBV siRNA THERAPEUTICS
WO2022269362A2 (en) * 2021-06-21 2022-12-29 Vaxxinova International B.V. Veterinary viral vector
WO2022271684A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271659A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
KR20240005901A (ko) 2021-06-23 2024-01-12 길리애드 사이언시즈, 인코포레이티드 디아실글리세롤 키나제 조절 화합물
JP7686086B2 (ja) 2021-06-23 2025-05-30 ギリアード サイエンシーズ， インコーポレイテッド ジアシルグリエルコール（ｄｉａｃｙｌｇｌｙｅｒｃｏｌ）キナーゼ調節化合物
EP4429698A1 (en) * 2021-11-08 2024-09-18 Hookipa Biotech GmbH Modified arenavirus particles expressing mutant kras, mutated cancer driver gene, or tumor-associated antigen as cancer immunotherapies
WO2023152116A1 (en) 2022-02-08 2023-08-17 Hookipa Biotech Gmbh Combination therapy with arenavirus particles and immune checkpoint modulators or cytokines
CN119677546A (zh) 2022-07-12 2025-03-21 吉利德科学公司 Hiv免疫原性多肽和疫苗及其用途
WO2025191169A1 (en) 2024-03-15 2025-09-18 Hookipa Biotech Gmbh Modified arenavirus particles expressing cancer testis antigens as cancer immunotherapies
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IL262963B1 (en) 2024-09-01
MX2024005757A (es) 2024-05-24
JP2023012463A (ja) 2023-01-25
KR20240095333A (ko) 2024-06-25
IL262963B2 (en) 2025-01-01
MX2018013956A (es) 2019-07-04
IL314272A (en) 2024-09-01
NZ788311A (en) 2025-11-28
WO2017198726A1 (en) 2017-11-23
CA3023599A1 (en) 2017-11-23
US20220289797A1 (en) 2022-09-15
BR112018073794A2 (pt) 2019-02-26
CN109804074B (zh) 2023-10-10
AU2023285703A1 (en) 2024-01-18
CN117486979A (zh) 2024-02-02
KR20190016032A (ko) 2019-02-15
CN109804074A (zh) 2019-05-24
IL262963A (en) 2018-12-31
NZ748120A (en) 2025-08-29
EP3458593A1 (en) 2019-03-27
EA201892648A1 (ru) 2019-06-28
JP2019516410A (ja) 2019-06-20
JP2024170461A (ja) 2024-12-10
AU2017266738B2 (en) 2023-10-12
SG11201810048VA (en) 2018-12-28
JP7547433B2 (ja) 2024-09-09
KR102671785B1 (ko) 2024-06-04
US20190135875A1 (en) 2019-05-09
AU2017266738A1 (en) 2018-11-29

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