JP7241352B2 - 肺扁平上皮癌のサブタイピングのための方法 - Google Patents

肺扁平上皮癌のサブタイピングのための方法 Download PDF

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JP7241352B2
JP7241352B2 JP2019512943A JP2019512943A JP7241352B2 JP 7241352 B2 JP7241352 B2 JP 7241352B2 JP 2019512943 A JP2019512943 A JP 2019512943A JP 2019512943 A JP2019512943 A JP 2019512943A JP 7241352 B2 JP7241352 B2 JP 7241352B2
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ハワジン ファルキ，
マイラ ライ－ゴールドマン，
グレッグ メイヒュー，
ジョナサン セロディー，
チャールズ ペロウ，
デイビッド ニール ヘイズ，
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University of North Carolina at Chapel Hill
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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JP2019512943A 2016-05-17 2017-05-17 肺扁平上皮癌のサブタイピングのための方法 Active JP7241352B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201662337645P 2016-05-17 2016-05-17
US62/337,645 2016-05-17
US201662379402P 2016-08-25 2016-08-25
US62/379,402 2016-08-25
US201662396587P 2016-09-19 2016-09-19
US62/396,587 2016-09-19
US201662420836P 2016-11-11 2016-11-11
US62/420,836 2016-11-11
US201662425717P 2016-11-23 2016-11-23
US62/425,717 2016-11-23
PCT/US2017/033107 WO2017201164A1 (en) 2016-05-17 2017-05-17 Methods for subtyping of lung squamous cell carcinoma

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JP2019516406A JP2019516406A (ja) 2019-06-20
JP2019516406A5 JP2019516406A5 (https=) 2020-06-25
JP7241352B2 true JP7241352B2 (ja) 2023-03-17

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US (2) US11041214B2 (https=)
EP (1) EP3458611B1 (https=)
JP (1) JP7241352B2 (https=)
CN (1) CN109863251B (https=)
CA (1) CA3024744A1 (https=)
WO (1) WO2017201164A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10829819B2 (en) 2014-05-30 2020-11-10 Genecentric Therapeutics, Inc. Methods for typing of lung cancer
AU2016343937B2 (en) 2015-10-30 2023-01-19 Exact Sciences Corporation Multiplex amplification detection assay and isolation and detection of DNA from plasma
US11041214B2 (en) 2016-05-17 2021-06-22 Genecentric Therapeutics, Inc. Methods for subtyping of lung squamous cell carcinoma
CN109790583B (zh) 2016-05-17 2023-08-25 基因中心治疗公司 对肺腺癌亚型分型的方法
CA3090912A1 (en) 2018-02-13 2019-08-22 Genecentric Therapeutics, Inc. Methods for subtyping of bladder cancer
CA3115922A1 (en) 2018-10-09 2020-04-16 Genecentric Therapeutics, Inc. Detecting cancer cell of origin
DE102018125324A1 (de) * 2018-10-12 2020-04-16 Universität Rostock Verfahren zur Vorhersage einer Antwort auf die Therapie von Krankheiten
WO2021041726A1 (en) * 2019-08-27 2021-03-04 Exact Sciences Development Company, Llc Characterizing methylated dna, rna, and proteins in subjects suspected of having lung neoplasia
CN111369501B (zh) * 2020-02-24 2022-04-01 武汉大学 一种基于视觉特征识别口腔鳞状细胞癌的深度学习方法
CN111653312B (zh) * 2020-05-28 2021-04-16 上海宝藤生物医药科技股份有限公司 一种利用基因组数据探究疾病亚型亲缘性的方法
CN111755073B (zh) * 2020-05-31 2022-11-15 复旦大学 基于转录组的pd-1疗法治疗效果预测系统
CN112433054A (zh) * 2020-11-20 2021-03-02 四川大学华西医院 C9蛋白检测试剂在制备肺癌筛查试剂盒中的用途
WO2022226391A1 (en) * 2021-04-23 2022-10-27 The Trustees Of Columbia University In The City Of New York Methods for detecting squamous cancer
CN115308418B (zh) * 2022-07-07 2024-11-08 翁良 一种生物标志物及其在肺鳞癌诊断中的应用
CN115982644B (zh) * 2023-01-19 2024-04-30 中国医学科学院肿瘤医院 一种食管鳞状细胞癌分类模型构建与数据处理方法
CN116129998B (zh) * 2023-01-19 2024-06-11 中国医学科学院肿瘤医院 一种食管鳞状细胞癌数据的处理方法及其系统
CN116287253B (zh) * 2023-02-22 2024-06-28 武汉科技大学 一种肺癌分子标志物及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010540672A (ja) 2007-10-09 2010-12-24 キュアバック ゲーエムベーハー 肺癌治療用、特に非小細胞肺癌（ｎｓｃｌｃ）治療用組成物
JP2015521480A (ja) 2012-06-18 2015-07-30 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ 頭頸部癌予後に関する方法
WO2015173267A1 (en) 2014-05-13 2015-11-19 Medimmune Limited Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small cell lung cancer
WO2016061142A1 (en) 2014-10-14 2016-04-21 Novartis Ag Antibody molecules to pd-l1 and uses thereof
US20160109453A1 (en) 2013-05-24 2016-04-21 Ait Austrian Institute Of Technology Gmbh Lung Cancer Diagnostic Method and Means

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4843155A (en) 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
JP2001524926A (ja) 1991-09-18 2001-12-04 アフィマックス テクノロジーズ ナームロゼ フェンノートシャップ オリゴマーの雑多ライブラリーの集合体を合成する方法
DE69233501T2 (de) 1991-11-22 2006-02-23 Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara Kombinatorische Strategien für die Polymersynthese
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
EP1027456B1 (en) 1997-10-31 2005-03-16 Affymetrix, Inc. (a Delaware Corporation) Expression profiles in adult and fetal organs
US6020135A (en) 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
US6670321B1 (en) 1998-12-30 2003-12-30 The Children's Medical Center Corporation Prevention and treatment for retinal ischemia and edema
US20030092009A1 (en) 2000-11-16 2003-05-15 Kaia Palm Profiling tumor specific markers for the diagnosis and treatment of neoplastic disease
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US20040009489A1 (en) 2001-09-28 2004-01-15 Golub Todd R. Classification of lung carcinomas using gene expression analysis
US20060024692A1 (en) 2002-09-30 2006-02-02 Oncotherapy Science, Inc. Method for diagnosing non-small cell lung cancers
TW200413725A (en) 2002-09-30 2004-08-01 Oncotherapy Science Inc Method for diagnosing non-small cell lung cancers
JP2007006792A (ja) 2005-06-30 2007-01-18 Hitachi Software Eng Co Ltd 肺腺癌の胸膜浸潤を判別するための遺伝子セット
US8822153B2 (en) 2007-06-01 2014-09-02 The University Of North Carolina At Chapel Hill Molecular diagnosis and typing of lung cancer variants
US20110224313A1 (en) 2008-06-05 2011-09-15 British Columbia Cancer Agency Branch Compositions and methods for classifying lung cancer and prognosing lung cancer survival
CN101509035A (zh) 2008-09-05 2009-08-19 中国人民解放军总医院 肺癌分型的基因序列及其应用
US9846162B2 (en) * 2012-05-14 2017-12-19 Yale University Immune biomarkers and assays predictive of clinical response to immunotherapy for cancer
US20150057335A1 (en) 2013-08-20 2015-02-26 National Cancer Center Novel fusion genes identified in lung cancer
EP3149042B1 (en) 2014-05-29 2019-08-28 Spring Bioscience Corporation Pd-l1 antibodies and uses thereof
US10829819B2 (en) 2014-05-30 2020-11-10 Genecentric Therapeutics, Inc. Methods for typing of lung cancer
WO2016168446A1 (en) 2015-04-14 2016-10-20 Genecentric Diagnostics, Inc. Methods for typing of lung cancer
US11041214B2 (en) 2016-05-17 2021-06-22 Genecentric Therapeutics, Inc. Methods for subtyping of lung squamous cell carcinoma
CN109790583B (zh) 2016-05-17 2023-08-25 基因中心治疗公司 对肺腺癌亚型分型的方法
US11739386B2 (en) 2017-07-21 2023-08-29 Genecentric Therapeutics, Inc. Methods for determining response to PARP inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010540672A (ja) 2007-10-09 2010-12-24 キュアバック ゲーエムベーハー 肺癌治療用、特に非小細胞肺癌（ｎｓｃｌｃ）治療用組成物
JP2015521480A (ja) 2012-06-18 2015-07-30 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ 頭頸部癌予後に関する方法
US20160109453A1 (en) 2013-05-24 2016-04-21 Ait Austrian Institute Of Technology Gmbh Lung Cancer Diagnostic Method and Means
WO2015173267A1 (en) 2014-05-13 2015-11-19 Medimmune Limited Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small cell lung cancer
WO2016061142A1 (en) 2014-10-14 2016-04-21 Novartis Ag Antibody molecules to pd-l1 and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Matthew D Wilkerson，Clinical Cancer Res. ，2010年，16(19)，4864-75.
肺がんの新規免疫療法，免疫療法ニュースピックアップ，https://web.archive.org/web/20160313081253/https://www.gan-info.jp/dendritic/newspickup/article02/，[Online]，２０１６年３月１３日，［２０２１年6月9日検索］

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EP3458611A4 (en) 2020-02-26
WO2017201164A1 (en) 2017-11-23
US12139765B2 (en) 2024-11-12
US20190338366A1 (en) 2019-11-07
US20210340631A1 (en) 2021-11-04
EP3458611A1 (en) 2019-03-27
US11041214B2 (en) 2021-06-22
CN109863251B (zh) 2022-11-18
JP2019516406A (ja) 2019-06-20
EP3458611B1 (en) 2023-11-08
CA3024744A1 (en) 2017-11-23
CN109863251A (zh) 2019-06-07

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