JP7239179B2 - Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 - Google Patents
Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 Download PDFInfo
- Publication number
- JP7239179B2 JP7239179B2 JP2019518292A JP2019518292A JP7239179B2 JP 7239179 B2 JP7239179 B2 JP 7239179B2 JP 2019518292 A JP2019518292 A JP 2019518292A JP 2019518292 A JP2019518292 A JP 2019518292A JP 7239179 B2 JP7239179 B2 JP 7239179B2
- Authority
- JP
- Japan
- Prior art keywords
- cells
- particles
- exosomes
- combination
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023025895A JP2023078140A (ja) | 2016-10-05 | 2023-02-22 | Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662404520P | 2016-10-05 | 2016-10-05 | |
| US62/404,520 | 2016-10-05 | ||
| PCT/US2017/055352 WO2018067825A1 (en) | 2016-10-05 | 2017-10-05 | Methods and compositions related to nk cell and anti-pdl1 cancer therapies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023025895A Division JP2023078140A (ja) | 2016-10-05 | 2023-02-22 | Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019534258A JP2019534258A (ja) | 2019-11-28 |
| JP2019534258A5 JP2019534258A5 (enExample) | 2021-05-20 |
| JP7239179B2 true JP7239179B2 (ja) | 2023-03-14 |
Family
ID=61831979
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019518292A Active JP7239179B2 (ja) | 2016-10-05 | 2017-10-05 | Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 |
| JP2023025895A Pending JP2023078140A (ja) | 2016-10-05 | 2023-02-22 | Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023025895A Pending JP2023078140A (ja) | 2016-10-05 | 2023-02-22 | Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20190309070A1 (enExample) |
| EP (1) | EP3523416B1 (enExample) |
| JP (2) | JP7239179B2 (enExample) |
| KR (2) | KR102650803B1 (enExample) |
| CN (2) | CN118453850A (enExample) |
| AU (2) | AU2017340633B2 (enExample) |
| CA (1) | CA3039532A1 (enExample) |
| DK (1) | DK3523416T3 (enExample) |
| ES (1) | ES3014658T3 (enExample) |
| SG (1) | SG11201903032SA (enExample) |
| WO (1) | WO2018067825A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10300089B2 (en) * | 2016-11-08 | 2019-05-28 | University Of Central Florida Research Foundation, Inc. | Methods for high scale therapeutic production of memory NK cells |
| EP3746095A4 (en) | 2018-02-01 | 2021-04-21 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| KR102373502B1 (ko) * | 2018-05-14 | 2022-03-11 | 주식회사 금호에이치티 | 골수유래억제세포 관련 질환의 예방 및 치료 용도 |
| KR102721140B1 (ko) * | 2018-05-22 | 2024-10-24 | 이뮤너티바이오, 인크. | 폴록사머를 사용한 nk-92 세포 성장의 최적화 |
| CN109939127A (zh) * | 2018-06-13 | 2019-06-28 | 阿思科力(苏州)生物科技有限公司 | Nk细胞的应用及包括该nk细胞的药物组合物及其应用 |
| WO2020047462A2 (en) * | 2018-08-30 | 2020-03-05 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| US11518792B2 (en) | 2018-08-30 | 2022-12-06 | HCW Biologics, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| CA3108951A1 (en) | 2018-08-30 | 2020-03-05 | HCW Biologics, Inc. | Single-chain chimeric polypeptides and uses thereof |
| BR112021009485A2 (pt) * | 2018-11-15 | 2021-08-10 | Torque Therapeutics, Inc. | métodos e composições para imunoterapia de câncer |
| CN109652504B (zh) * | 2018-12-27 | 2021-03-16 | 杭州迪相实业有限公司 | 一种同时检测外泌体膜蛋白和mRNA的方法 |
| CN110205296B (zh) * | 2019-01-29 | 2021-08-24 | 上海鑫湾生物科技有限公司 | 具有Fc突变体的抗体与效应细胞的组合、用途和制法 |
| CA3143035A1 (en) | 2019-06-21 | 2020-12-24 | HCW Biologics, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| AU2021219720B2 (en) | 2020-02-11 | 2025-10-02 | Immunitybio, Inc. | Chromatography resin and uses thereof |
| CA3169231A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of treating age-related and inflammatory diseases |
| CN115380045A (zh) | 2020-02-11 | 2022-11-22 | Hcw生物科技公司 | 激活调节性t细胞的方法 |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| JP2023024168A (ja) * | 2021-08-06 | 2023-02-16 | 国立大学法人 長崎大学 | がんの治療剤 |
| CA3235938A1 (en) * | 2021-11-09 | 2023-05-19 | Ayman Kabakibi | Combination cancer therapy with memory nk cells and anti-cancer bispecific molecules |
| WO2023247324A1 (en) * | 2022-06-24 | 2023-12-28 | Cytovac A/S | Novel combination treatment with adoptive cellular therapy |
| WO2024108058A2 (en) * | 2022-11-18 | 2024-05-23 | Nkmax Co., Ltd. | Methods of inducing pd-l1 expression |
| US20250011718A1 (en) * | 2023-07-05 | 2025-01-09 | Immunitybio, Inc. | Ex Vivo Generation of Immune Effector Cells from Apheresis Material Intermediates |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150359853A1 (en) | 2012-10-24 | 2015-12-17 | Admune Therapeutics Llc | Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1601438A (enExample) | 1968-10-17 | 1970-08-24 | ||
| US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| WO1991010741A1 (en) | 1990-01-12 | 1991-07-25 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
| CA2090473A1 (en) | 1990-08-29 | 1992-03-01 | Robert M. Kay | Homologous recombinatin in mammalian cells |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5652138A (en) | 1992-09-30 | 1997-07-29 | The Scripps Research Institute | Human neutralizing monoclonal antibodies to human immunodeficiency virus |
| ES2108460T3 (es) | 1993-06-03 | 1997-12-16 | Therapeutic Antibodies Inc | Fragmentos de anticuerpos en terapeutica. |
| US6180377B1 (en) | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
| US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
| FR2765243B1 (fr) | 1997-06-30 | 1999-07-30 | Usinor | Acier inoxydable austenoferritique a tres bas nickel et presentant un fort allongement en traction |
| JP6639228B2 (ja) * | 2012-03-29 | 2020-02-05 | アルター・バイオサイエンス・コーポレーション | 新生物を治療するための方法 |
| RS64172B1 (sr) * | 2012-06-28 | 2023-05-31 | Univ Of Central Florida Research Foundation Incorporated | Postupci i kompozicije za ćelije prirodne ubice |
| CN103536917B (zh) * | 2013-10-30 | 2015-03-11 | 苏州丁孚靶点生物技术有限公司 | 干扰素在治疗肿瘤中的用途及相关的产品和方法 |
| ES2991853T3 (es) * | 2013-11-05 | 2024-12-05 | Cognate Bioservices Inc | Combinaciones de inhibidores del punto de control y terapéuticos para tratar el cáncer |
| HK1245080A1 (zh) * | 2014-10-27 | 2018-08-24 | University Of Central Florida Research Foundation, Inc. | 自然杀伤细胞的方法和组合物 |
| SG11201704056XA (en) * | 2014-11-20 | 2017-06-29 | Hoffmann La Roche | Combination therapy of t cell activating bispecific antigen binding molecules cd3 abd folate receptor 1 (folr1) and pd-1 axis binding antagonists |
| EP3259352A4 (en) | 2015-02-19 | 2018-12-05 | University of Florida Research Foundation, Inc. | Chimeric antigen receptors and uses thereof |
| SG11201707383PA (en) | 2015-03-13 | 2017-10-30 | Cytomx Therapeutics Inc | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
-
2017
- 2017-10-05 CN CN202410266765.3A patent/CN118453850A/zh active Pending
- 2017-10-05 US US16/339,781 patent/US20190309070A1/en not_active Abandoned
- 2017-10-05 ES ES17859189T patent/ES3014658T3/es active Active
- 2017-10-05 DK DK17859189.7T patent/DK3523416T3/da active
- 2017-10-05 WO PCT/US2017/055352 patent/WO2018067825A1/en not_active Ceased
- 2017-10-05 SG SG11201903032SA patent/SG11201903032SA/en unknown
- 2017-10-05 KR KR1020197012752A patent/KR102650803B1/ko active Active
- 2017-10-05 JP JP2019518292A patent/JP7239179B2/ja active Active
- 2017-10-05 EP EP17859189.7A patent/EP3523416B1/en active Active
- 2017-10-05 CA CA3039532A patent/CA3039532A1/en active Pending
- 2017-10-05 CN CN201780069203.8A patent/CN109952369B/zh active Active
- 2017-10-05 AU AU2017340633A patent/AU2017340633B2/en active Active
- 2017-10-05 KR KR1020247009187A patent/KR20240042177A/ko active Pending
-
2023
- 2023-02-22 JP JP2023025895A patent/JP2023078140A/ja active Pending
-
2024
- 2024-04-11 AU AU2024202350A patent/AU2024202350A1/en active Pending
-
2025
- 2025-01-06 US US19/011,349 patent/US20250136698A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150359853A1 (en) | 2012-10-24 | 2015-12-17 | Admune Therapeutics Llc | Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes |
Non-Patent Citations (5)
| Title |
|---|
| Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells,Cancer Immunology Research,2015年,Vol. 3, No. 10,p. 1148-1157 |
| Interleukin-18 (IL-18)によるNatural Killer (NK)細胞活性化および腫瘍細胞のアポトーシス誘導,頭頸部腫瘍,Vol. 29, No. 1,2003年,p. 217-223 |
| Interleukin-21 Increases Direct Cytotoxicity and IFN-γ Production of Ex Vivo Expanded NK Cells towards Breast Cancer Cells,Anticancer Research,2012年,Vol. 32,p. 839-846 |
| Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells,PLOS ONE,2012年,Vol. 7, No. 1,e30264 |
| Natural killer cells stimulated with PM21 particles expand and biodistribute in vivo: Clinical implications for cancer treatment,Cytotherapy,Vol. 18, No. 5,p. 653-663,doi: 10.1016/j.jcyt.2016.02.006. |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019534258A (ja) | 2019-11-28 |
| KR20240042177A (ko) | 2024-04-01 |
| CN118453850A (zh) | 2024-08-09 |
| US20190309070A1 (en) | 2019-10-10 |
| WO2018067825A1 (en) | 2018-04-12 |
| AU2017340633A1 (en) | 2019-05-23 |
| ES3014658T3 (en) | 2025-04-23 |
| US20250136698A1 (en) | 2025-05-01 |
| DK3523416T3 (da) | 2025-03-03 |
| SG11201903032SA (en) | 2019-05-30 |
| CA3039532A1 (en) | 2018-04-12 |
| EP3523416B1 (en) | 2025-02-19 |
| JP2023078140A (ja) | 2023-06-06 |
| CN109952369A (zh) | 2019-06-28 |
| KR20190066035A (ko) | 2019-06-12 |
| AU2024202350A1 (en) | 2024-05-02 |
| CN109952369B (zh) | 2024-03-22 |
| KR102650803B1 (ko) | 2024-03-25 |
| AU2017340633B2 (en) | 2024-01-11 |
| EP3523416A4 (en) | 2020-04-15 |
| EP3523416A1 (en) | 2019-08-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7239179B2 (ja) | Nk細胞および抗pdl1による癌治療法に関連する方法および組成物 | |
| CN113543799B (zh) | 靶向dll3的嵌合抗原受体和结合剂 | |
| CN113784983B (zh) | Cd93特异性治疗性抗原结合蛋白及其使用方法 | |
| TWI862870B (zh) | 嵌合抗原受體療法t細胞擴增動力學及其用途 | |
| TW202328202A (zh) | 記憶性nk細胞及抗癌雙特異性分子的組合癌症療法 | |
| KR20240012413A (ko) | 폐암 치료를 위한 조성물 및 방법 | |
| IL311901A (en) | Multiple specific binding agents against PD-L1 and CD137 in combination therapy | |
| TWI882495B (zh) | 用於將免疫療法最佳化之因素 | |
| Brossart et al. | OPEN ACCESS EDITED AND REVIEWED BY | |
| HK40046063A (en) | Chimeric antigen receptor therapy t cell expansion kinetics and uses thereof | |
| HK40063038B (zh) | 靶向dll3的嵌合抗原受体和结合剂 | |
| HK40063038A (en) | Dll3 targeting chimeric antigen receptors and binding agents |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20201001 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210407 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210907 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20211202 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20211220 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220524 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20220823 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20221024 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20230124 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230222 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7239179 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |