JP7230117B2 - pest repellent for humans - Google Patents

Description

The present invention relates to a pest repellent for humans for protecting the human body from pests such as mosquitoes, gnats, biting flies, house dust mites, and bed bugs. and a method for suppressing penetration of an insect repellent component into the skin.

Various patents have been filed for pest repellents for the human body for the purpose of improving the feeling of use and reducing irritation. Pest repellents for humans are basically applied to the exposed skin of the human body, such as arms, legs, and nape of the neck, i.e., parts that are susceptible to external stimuli. For the purpose of blending ultraviolet absorbers and ultraviolet scattering agents used in cosmetic raw materials, Patent Document 1 (Japanese Patent Application Laid-Open No. 5-92915) and Patent Document 2 (Japanese Patent Application Laid-Open No. 8- 183720), and patent document 3 (Japanese Patent Laid-Open No. 2003-160413) for the purpose of reducing the offensive odor of deet by blending ingredients that can be expected to have a moisturizing effect, such as aloe extract and peach extract. there is

On the other hand, some water-based pest repellents for humans have been proposed with the aim of improving the feeling of use and reducing irritation by incorporating water into the composition. For example, Patent Document 4 (Japanese Unexamined Patent Application Publication No. 2003-192503), in which a pest repellent component, a water-soluble solvent and water are blended and the blending ratio of the water-soluble solvent and water is specified to improve skin feel and odor, Patent Document 5 (Japanese Patent Laid-Open No. 11 - 349409). Furthermore, Patent Document 6 (Japanese Unexamined Patent Application Publication No. 2005-132780) discloses a useful pest repellent for humans in which natural mineral water is selected as the water to be blended and irritation is further reduced.

By the way, in order for the pest-repellent component applied to the skin to exert its pest-repellent effect continuously, it is also important to keep the pest-repellent component on the skin as much as possible and prevent it from permeating under the skin. Hitherto, measures have often been taken to enhance the sustainability of the pest-repellent effect by increasing the amount of the pest-repellent component, but this does not mean that the amount of the pest-repellent component should be increased recklessly.
For example, the water-based pest repellent for the human body of Patent Document 6, which contains natural mineral water, is useful in terms of improving the feeling of use and reducing irritation, but it is useful for suppressing penetration of the pest repellent component into the skin. However, no mention was made of the sustainability of the pest repellent effect, and further investigation was required.

JP-A-5-92915 JP-A-8-183720 Japanese Patent Application Laid-Open No. 2003-160413 Japanese Patent Application Laid-Open No. 2003-192503 JP-A-11-349409 Japanese Patent Application Laid-Open No. 2005-132780

The present invention has been devised in view of such circumstances, and aims to provide a water-based pest repellent for humans containing pest repellent components, which suppresses the penetration of pest repellent components into the skin and recklessly increases the blending amount of pest repellent components. An object of the present invention is to provide an agent for suppressing permeation of an insect repellent component into the skin, and a method for suppressing the permeation of an insect repellent component to the skin, which can improve the sustainability of the insect repellent effect without causing any damage.

The present invention has found that the following configuration has excellent effects for achieving the above object.
In order to solve the above problems, the present invention employs the following configuration.
(1) Suppression of permeation of the pest repellent component into the skin, which is blended in a pest repellent for human body containing the pest repellent component and is natural mineral water having an electrical conductivity of 1.5 mS/m to 30 mS/m. agent.
(2) The skin penetration inhibitor according to (1), wherein the natural mineral water is water containing desalted deep sea water.
(3) The pest repellent component includes 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate, ethyl 3-(Nn-butylacetamido)propionate, DEET, and p-menthane-3. , 8-diols.
(4) The skin penetration inhibitor according to (3), wherein the pest repellent component is 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate.
(5) The pest repellent for humans further contains one or more selected from alcohol compounds and/or glycol compounds having 2 to 6 carbon atoms of (1) to (4). The skin penetration inhibitor according to any one of the above.
(6) A method for suppressing permeation of a pest-repellent component into the skin, comprising blending a pest-repellent agent for humans containing a pest-repellent component with natural mineral water having an electric conductivity of 1.5 mS/m to 30 mS/m.
(7) The method for inhibiting skin permeation according to (6), wherein the natural mineral water is water containing desalted deep sea water.

The agent for suppressing penetration of pest-repellent ingredients into the skin of the present invention suppresses the penetration of pest-repellent ingredients into the skin in water-based pest-repellent agents for humans containing pest-repellent ingredients. It is very useful because it can improve the sustainability of the pest repellent effect without increasing the amount. In addition, the practicality of the method for suppressing permeation of pest repellent ingredients into the skin using this is extremely high.

The pest-repellent component used in the present invention includes various synthetic or natural compounds having repelling action or blood-sucking-inhibiting action against pests. For example, 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate [hereinafter referred to as icaridin], ethyl 3-(Nn-butylacetamido)propionate [hereinafter referred to as IR3535], Deet , p-menthane-3,8-diol, hexylene glycol, eucalyptol, α-pinene, geraniol, citronellal, camphor, linalool, caran-3,4-diol and the like. Examples of natural products include essential oils and extracts obtained from cinnamon bark, citronella, lemongrass, clover, bergamot, laurel, eucalyptus, etc. One or more of these can be selected and used. Among the above compounds and natural products, icaridin, IR3535, DEET, and p-menthane-3,8-diol are particularly preferred, and icaridin is especially preferred.
The amount of the pest-repellent component varies depending on the pest-repellent effect of each agent and the like.

The present invention provides a pest repellent for human body containing pest repellent components, which has an electric conductivity of 1.5 mS/m to 30 mS/m, preferably 2.5 mS, as an agent for suppressing penetration of the pest repellent components into the skin. /m to 15 mS/m of natural mineral water.
Examples of natural mineral water include spring water at the foot of mountains, deep underground water, surface water of the ocean, and deep ocean water, and since they contain metal ions such as magnesium ions, calcium ions, and potassium ions, their uses are attracting attention in various fields. It is For example, water filtered and desalted by a reverse osmosis membrane method or the like and adjusted to a hardness of about 100 to 1000 is sold as drinking water for the purpose of replenishing mineral components that tend to be deficient in the human body.

It has been known that when such a pest repellent for human body containing mineral water is directly applied to the skin, it is possible to provide a moisturizing and refreshing feeling due to the mineral component, but the mineral component allows the pest repellent component to permeate the skin. No mention has been made of how it affects It is presumed that this is because it was thought that the mineral component could not be expected to suppress the skin permeation of the pest repellent component, considering that the pest repellent component is easily washed away from the skin by the sweat component.
However, the present inventors have extensively studied the effects of mineral components in pest repellents for humans, and surprisingly, by blending natural mineral water with a specific electrical conductivity, this natural mineral It was found that water functions as an inhibitor of permeation of pest repellent ingredients into the skin. Then, they verified that the sustainability of the pest repelling effect can be improved, and completed the present invention.

In the present invention, the electric conductivity of natural mineral water to be blended is specified in the range of 1.5 mS/m to 30 mS/m, preferably 2.5 mS/m to 15 mS/m. Although related to the concentration of metal ions, it is a different index from the commonly used hardness.
If the electric conductivity is less than 1.5 mS/m, the effect of suppressing skin permeation of the pest repellent component cannot be expected. This is not preferable because it may interfere with the stability of the pest repellent composition for use.
In the present invention, if it is derived from natural mineral water, it is defined as "natural mineral water" including water diluted with deionized water and purified water, and the amount is the total amount of pest repellent for humans. 20 to 60% by mass is suitable for the
Among the above natural mineral waters, deep sea water collected from the aphotic layer at a depth of 200 m or more has a good balance of mineral components, and is excellent in cleanliness and stability. Then, this raw water is subjected to a desalination process, and if necessary, diluted with deionized water or purified water, and the electric conductivity is adjusted to a range of 1.5 mS / m to 30 mS / m. will be particularly suitable for

In order to solubilize water-insoluble pest repellent ingredients, the pest repellent for human body of the present invention usually contains one selected from alcohol compounds and/or glycol compounds having 2 to 6 carbon atoms, or Two or more kinds are blended.
Examples of such alcohol-based compounds and glycol-based compounds include ethanol and isopropanol, which are lower monohydric alcohols having 2 to 3 carbon atoms, and ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, 1,3-, which are glycol-based compounds. Butylene glycol and the like can be mentioned, and these can be used alone or in combination. When ethanol is used, it is preferable to use brewed ethanol, which has mild effects on the skin and is commonly used for food.
In the present invention, if the blending amount of the alcohol-based compound or the glycol-based compound is set to 30 to 70% by mass with respect to the total amount of the pest repellent for humans, it becomes possible to maintain good properties as a formulation. .

In the present invention, in addition to the above components, a surfactant may be blended in order to ensure the stability of the pest repellent composition for humans as long as it does not interfere with the gist of the present invention. As such a surfactant, a nonionic surfactant having an HLB of 11 to 16 is particularly preferable, and polyoxyethylene (10 mol) oleyl ether {HLB=12.4}, polyoxyethylene (20 mol) oleyl ether {HLB = 15.1}, polyoxyethylene (9 mol) lauryl ether {HLB = 13.6}, polyoxyethylene (10 mol) cetyl ether {HLB = 12.9}, polyoxyethylene (15 mol) stearyl Ether {HLB = 14.2}, polyoxyethylene alkyl ethers such as polyoxyethylene (15 mol) isostearyl ether {HLB = 14.2}, polyoxyethylene (20 mol) sorbitan monooleate {HLB = 15 .7}, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (10 mol) sorbitan monolaurate {HLB = 14.9}, polyoxyethylene (20 mol) sorbitan monostearate {HLB = 15.7} , polyoxyethylene (14 mol) monooleate {HLB = 13.7}, polyoxyethylene (9 mol) monolaurate {HLB = 13.3}, polyoxyethylene (14 mol) myristate {HLB = 14.6 } and the like, and these can be used singly or in combination.
Surfactants are preferably reduced as much as possible in consideration of irritation to the skin, but nonionic surfactants with an HLB of 11 to 16 are effective in stabilizing pest repellent compositions for humans even in small amounts. It is known.
In addition, it is reported that polyalkylene glycol having a molecular weight of about 200 to 5000, such as polyethylene glycol and polypropylene glycol, can suppress the penetration of pest repellent ingredients into the skin and reduce irritation to the skin. You may

In addition, in order to improve the feeling of use (dryness of the coated surface, etc.), inorganic powders such as silicic anhydride, talc and kaolin, and organic powders such as modified starch and silk fiber powder may be blended. In addition, antiphlogistic agents such as dipotassium glycyrrhizinate, allantoin, alkyltrimethylammonium chloride, tocopherol acetate, and camphor, and UV absorbers such as para-aminobenzoic acid, amyl salicinate, octylcinnamate, octyl methoxycinnamate, and 2,4-dihydroxybenzophenone. agents, UV scattering agents, antiperspirants such as aluminum sulfate, aluminum chlorohydroxy, and zinc phenolsulfonate; It is possible.

The pest repellent for humans prepared in this manner is water-based, has high safety against fire, and hardly irritates the human body. There are no particular restrictions on the form of use, but specific examples of use include the form of filling non-aerosol type spray agents and roll-on type containers, the form of impregnating sheet substrates such as nonwoven fabrics, and the like, as well as liquefied petroleum. Of course, gas, dimethyl ether, compressed gas (nitrogen gas, compressed air, etc.) can also be used as a propellant to form an aerosol agent, and the range of application is extremely wide.

The agent for suppressing penetration of the pest repellent component into the skin of the present invention, which is incorporated in such a pest repellent for human body, suppresses the penetration of the pest repellent component into the skin and prevents mosquitoes, gnats, biting flies, house dust mites, bed bugs, and the like. Since it can improve the sustainability of the pest-repellent effect, it is very useful for biting damage control. In addition, the practicality of the method for suppressing permeation of pest repellent ingredients into the skin using this is extremely high.

Next, based on specific examples and test examples, the agent for suppressing penetration of pest repellent ingredients into skin and the method for suppressing penetration of pest repellent ingredients into skin of the present invention will be described in more detail.

After uniformly dissolving 5.0 g of Icaridin as a pest repellent component in 55.0 g of brewed ethanol, 40.0 g of desalted deep sea water (electrical conductivity: 3.8 mS/m) was added to prepare pest repellent for humans. got the drug.
This pest repellent composition for humans remained uniform and clear even after being stored in a constant temperature bath at 5°C and 40°C for one month. Next, the pest repellent for the human body was used by being filled in a pressure-accumulating pump container. About 1 mL of the product was applied to the back of the hand, and after 1 minute had passed, the state of the applied surface was observed. In addition, since the pest repellent for the body contains an inhibitor of permeation of the pest repellent component into the skin, the pest repellent effect of the applied part lasts for about 10 hours, during which no pests such as mosquitoes bothered the user. .

Various pest repellents for humans shown in Table 1 were prepared according to Example 1, and the following tests were performed.
(1) Feeling after use About 1 mL of the product was applied to the back of the hand, and after 1 minute had passed, the coated surface was touched with a fingertip to evaluate the feel. The results are shown in Table 1 as ◯ (light feeling), Δ (slightly sticky), and × (sticky, rough skin).
(2) Insect repellent effect test About 3 mL was applied to the arm of the tester, and the tester stood in an outdoor test site where many Aedes mosquitoes inhabited, and measured the time until the mosquito landed on the arm. The test was repeated four times by changing testers, and the average pest repellent effect duration was obtained. The results are shown in Table 1, ◎ (9 hours or more), ○ (7 to 9 hours),
Δ (6 to 7 hours) and × (less than 6 hours).

As a result of the test, the skin penetration inhibitor of the pest repellent component of the present invention, that is, natural mineral water with an electric conductivity of 1.5 mS/m to 30 mS/m, preferably 2.5 mS/m to 15 mS/m, was used. When the compounded pest repellent for humans was applied to the back of the hand and put into practical use, it gave a refreshing feeling without stickiness, and the permeation of the pest repellent ingredient into the skin was suppressed, increasing the percentage of pest repellents remaining on the skin. Therefore, it was confirmed that the pest repellent effect was excellent in sustainability.
As the natural mineral water, water containing desalted deep sea water is preferable. Considering the combination with the natural mineral water, IR3535, DEET and p-menthane-3,8 are preferable as the pest-repellent component. - It was also found that icaridin fits the spirit of the invention better than diols.
On the other hand, Comparative Examples 1 to 5 (pest repellents containing deionized water or water with electrical conductivity outside the range of 1.5 mS / m to 30 mS / m) have a feeling of use and persistence of pest repelling effect somewhat inferior in terms of
Furthermore, from a comparison between the product 10 of the present invention and Comparative Example 6, even when deionized water is used, it is possible to increase the amount of the pest repellent component and to enhance the sustainability of the pest repellent effect, but the feeling of use is not good. It is clear that this method may not always be an effective method, as it may lead to a decrease in performance.

INDUSTRIAL APPLICABILITY The agent for suppressing permeation of pest-repellent ingredients into skin and the method for suppressing permeation of pest-repellent ingredients into skin of the present invention may be applied to pest-repellent fields other than those for the human body.

Claims (2)

an insect repellent component;
Desalted deep sea water, which is natural mineral water with an electrical conductivity of 2.5 mS/m to 15 mS/m;
ethanol;
contains
The pest repellent for humans, wherein the pest repellent component is one or more selected from ethyl 3-(Nn-butylacetamido)propionate, DEET, and p-menthane-3,8-diol. 2. The pest repellent for human body according to claim 1, wherein the duration of pest repellent effect is 7 hours or more.