JP2018118922A - Agent and method for inhibiting penetration of pest repellent component into the skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide, in a pest repellent component-containing aqueous human pest repellent, an agent for inhibiting penetration of a pest repellent component into the skin that can inhibit penetration of a pest repellent component into the skin and improve the persistence of pest repellent effect without unnecessarily increasing the blending amount of pest repellent component, and to provide a method for inhibiting penetration of pest repellent component into the skin.SOLUTION FOR THE PROBLEM: Provided is an agent for inhibiting penetration of a pest repellent component into the skin, that is blended in a pest repellent component-containing aqueous human pest repellent and is a natural mineral water having an electric conductivity of 1.5 mS/m to 30 mS/m. The natural mineral water preferably is a water containing desalinated ocean deep water, and furthermore the pest repellent component preferably is 1-methylpropyl 2-(2-hydroxyethyl)-1-piperidine carboxylate.SELECTED DRAWING: None

Description

The present invention relates to a pest repellent for the human body for protecting the human body from pests such as mosquitoes, gnats, sand flies, house dust mites, bed bugs, and the like, specifically, to the skin of pest repellent ingredients blended in this human pest repellent This invention relates to a method for suppressing the penetration of a pest and a pest repellent component into the skin.

Conventionally, various patents have been filed for the purpose of improving the feeling of use and reducing the irritation. The pest repellent for human body is basically applied to the exposed skin of the human body, such as arms, legs, neck, etc., that is, the part susceptible to external irritation. Patent Document 1 (Japanese Patent Laid-Open No. 5-92915) and Patent Document 2 (Japanese Patent Laid-Open No. Hei 8-) aiming at repelling pests and preventing sunburn by blending UV absorbers and UV scattering agents used in cosmetic raw materials for the purpose. No. 183720) has also been filed with Patent Document 3 (Japanese Patent Application Laid-Open No. 2003-160413) and the like for blending ingredients that can be expected to have a moisturizing effect, such as aloe extract and peach extract, for the purpose of reducing the odor of diet. Yes.

On the other hand, some water-based pest repellents for human body aiming at improving the feeling of use and reducing irritation by blending water in the composition have been proposed. For example, a pest repellent component, a water-soluble solvent, and water are blended, and by defining the blending ratio of the water-soluble solvent and water, Patent Document 4 (Japanese Patent Laid-Open No. 2003-192503) that improves skin feel and odor, Patent Document 5 (Patent Document 5) which contains a pest repellent component, an alcohol compound or a glycol compound, a surfactant and water to stabilize the pest repellent component and to reduce dryness and irritation to sensitive skin. No. 349409). Furthermore, patent document 6 (Unexamined-Japanese-Patent No. 2005-132780) is disclosing the useful human insect pest repellent from which natural mineral water was selected as water to mix | blend, and irritation was further reduced.

By the way, in order for the pest repellent component applied to the skin to exert the pest repellent effect continuously, it is also important that the pest repellent component stays on the skin as much as possible and does not penetrate the skin. Conventionally, measures have been often taken to increase the amount of the pest repellent component to increase the sustainability of the pest repellent effect, but this does not mean that the amount of the pest repellent component can be increased in a dark manner.
For example, the aqueous pest repellent for human body of Patent Document 6 containing natural mineral water is useful in terms of improving the feeling of use and reducing irritation. No mention was made of the sustainability of the pest repellent effect, and further studies were required.

JP-A-5-92915 JP-A-8-183720 JP 2003-160413 A JP 2003-192503 A JP 11-349409 A JP 2005-132780 A

The present invention has been made in view of the present situation, and in an aqueous pest repellent containing a pest repellent component, the penetration of the pest repellent component into the skin is suppressed, and the compounding amount of the pest repellent component is increased without darkness. An object of the present invention is to provide an agent for suppressing the penetration of a pest repellent component into the skin and a method for suppressing the penetration of the pest repellent component into the skin, which can improve the sustainability of the pest repellent effect.

The present invention has been found that the following constitution has an excellent effect for achieving the above-mentioned object.
In order to solve the above problems, the present invention employs the following configuration.
(1) Inhibition of penetration of the pest repellent component into the skin, which is a natural mineral water blended with a pest repellent for human body containing a pest repellent component and having an electric conductivity of 1.5 mS / m to 30 mS / m Agent.
(2) The skin mineral penetration inhibitor according to (1), wherein the natural mineral water is water containing desalted deep ocean water.
(3) The pest repellent component comprises 2- (2-hydroxyethyl) -1-piperidinecarboxylic acid 1-methylpropyl, ethyl 3- (Nn-butylacetamido) propionate, diet, and p-menthane-3 , 8-diol selected from (1) or (2) is a skin penetration inhibitor according to (1) or (2).
(4) The skin penetration inhibitor according to (3), wherein the pest repellent component is 1-methylpropyl 2- (2-hydroxyethyl) -1-piperidinecarboxylate.
(5) The pest repellent for human body further contains one or more selected from alcoholic compounds and / or glycolic compounds having 2 to 6 carbon atoms (1) to (4) The skin penetration inhibitor according to any one of the above.
(6) A method for suppressing penetration of the pest repellent component into the skin, wherein a natural mineral water having an electrical conductivity of 1.5 mS / m to 30 mS / m is blended with the pest repellent for human body containing the pest repellent component.
(7) The skin mineralization suppression method according to (6), wherein the natural mineral water is water containing desalted deep ocean water.

The skin penetration inhibitor of the pest repellent component of the present invention is an aqueous human pest repellent containing a pest repellent component, which suppresses the penetration of the pest repellent component into the skin, and the amount of the pest repellent component blended It is very useful because it can improve the sustainability of the insect repellent effect without increasing it. And the practical use of the penetration control method to the skin of the insect repellent component using this is also very high.

Examples of the pest repellent component used in the present invention include various synthetic or natural compounds having a repellent action or blood sucking inhibitory action against pests. For example, 1-methylpropyl 2- (2-hydroxyethyl) -1-piperidinecarboxylate [hereinafter referred to as icaridin], ethyl 3- (Nn-butylacetamido) propionate [hereinafter referred to as IR3535], Diet , P-menthane-3,8-diol, hexylene glycol, eucalyptol, α-pinene, geraniol, citronellal, camphor, linalool, caran-3,4-diol, and the like. Furthermore, examples of natural products include essential oils and extracts from cinnamon bark, citronella, lemongrass, clover, bergamot, laurel, eucalyptus, etc., and one or more of these can be selected and used. Of the above compounds and natural products, icaridin, IR3535, diet, and p-menthane-3,8-diol are particularly preferred, and icaridin is particularly preferred.
The pest repellent component varies depending on the pest repellent effect of each drug, but is 1 to 50% by mass, preferably 3 to 30% by mass, based on the total amount of the pest repellent for human body of the present invention.

The present invention provides a human body pest repellent containing a pest repellent component, and has an electrical conductivity of 1.5 mS / m to 30 mS / m, preferably 2.5 mS as a penetration inhibitor for the skin of the pest repellent component. It is characterized by blending natural mineral water of / m to 15 mS / m.
Natural mineral water includes water at the foot of the mountain, deep underground water, ocean surface water, deep ocean water, etc., and contains metal ions such as magnesium ions, calcium ions, potassium ions, etc. Has been. For example, what is filtered and desalted by the reverse osmosis membrane method and adjusted to a hardness of about 100 to 1000 is sold as drinking water for the purpose of replenishing mineral components that tend to be deficient in the human body.

It has been known that when such a pest repellent for human body containing mineral water is directly applied to the skin, it can provide moisturizing feeling and refreshing feeling due to the mineral component, but the mineral component penetrates the pest repellent component into the skin. There has never been any mention of how it affects the system. This is presumably because the pest repellent component was likely to be washed away from the skin by the sweat component, and it was thought that the pest repellent component was not expected to inhibit skin penetration by the mineral component.
However, the present inventors have conducted extensive studies on the action of the mineral component in the pest repellent for human body, and surprisingly, by adding natural mineral water having a specific electric conductivity, It was found that water functions as a penetration inhibitor for pest repellent ingredients. And it verified that the sustainability of a pest repellent effect could be improved, and came to complete this invention.

In the present invention, the electrical conductivity of the natural mineral water to be blended is defined in the range of 1.5 mS / m to 30 mS / m, preferably 2.5 mS / m to 15 mS / m. Although it is related to the metal ion concentration, it is a different index from the commonly used hardness.
If the electrical conductivity is less than 1.5 mS / m, the pest repellent component can not be expected to inhibit skin permeation, while if it exceeds 30 mS / m, not only the corresponding skin permeation inhibition can be obtained. This is not preferable because the stability of the insect pest repellent composition may be hindered.
In the present invention, if it is derived from natural mineral water, it is defined as “natural mineral water” including water diluted with deionized water or purified water, and its blending amount is the total amount of pest repellent for human body 20-60 mass% is suitable with respect to this.
Among the above-mentioned natural mineral waters, deep sea water collected from a non-light layer having a depth of 200 m or more has a good balance of mineral components, and has good cleanliness and stability. The raw water is subjected to a desalting step, and if necessary, it is diluted with deionized water or purified water, and the electrical conductivity is adjusted to a range of 1.5 mS / m to 30 mS / m. It is particularly suitable for

In order to solubilize the pest repellent component insoluble in water, the pest repellent for human body of the present invention is usually one kind selected from alcohol compounds and / or glycol compounds having 2 to 6 carbon atoms or Two or more kinds are blended.
Examples of such alcohol compounds and glycol compounds include ethanol and isopropanol, which are lower monohydric alcohols having 2 to 3 carbon atoms, and ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, 1,3-carbon, which are glycol compounds. Butylene glycol etc. are mentioned, These can be used individually or in mixture. In addition, when using ethanol, the effect | action on a skin is relieve | moderated and general brewed ethanol for foods is preferable.
In the present invention, if the blending amount of the alcohol compound or glycol compound is set to 30 to 70% by mass with respect to the total amount of the pest repellent for human body, it is possible to maintain good properties as a preparation. .

In the present invention, a surfactant may be blended in addition to the above components in order to ensure the stability of the pest repellent composition for human body, as long as the gist of the present invention is not impaired. As such a surfactant, a nonionic surfactant having an HLB of 11 to 16 is particularly preferable. Polyoxyethylene (10 mol) oleyl ether {HLB = 12.4}, polyoxyethylene (20 mol) oleyl ether {HLB = 15.1}, polyoxyethylene (9 mol) lauryl ether {HLB = 13.6}, polyoxyethylene (10 mol) cetyl ether {HLB = 12.9}, polyoxyethylene (15 mol) stearyl Polyoxyethylene alkyl ethers such as ether {HLB = 14.2}, polyoxyethylene (15 mol) isostearyl ether {HLB = 14.2}, polyoxyethylene (20 mol) sorbitan monooleate {HLB = 15 .7}, polyoxyethylene (10 mol) sorbitan monolaurate {HLB = 14.9}, polyoxyethylene (20 mol) sorbitan monostearate {HLB = 15.7} and other polyoxyethylene sorbitan fatty acid esters, polyoxyethylene (14 mol) monooleate {HLB = 13.7 }, Polyoxyethylene (9 mol) monolaurate {HLB = 13.3}, polyoxyethylene (14 mol) myristate {HLB = 14.6} and other polyoxyethylene alkyl esters, and the like. Can be used alone or in admixture.
It is preferable to reduce the surfactant as much as possible in consideration of irritation to the skin. However, the nonionic surfactant having an HLB of 11 to 16 has an effect for stabilizing the pest repellent composition for human body with a small amount. It is known.
There are also reports that polyalkylene glycols with a molecular weight of about 200 to 5000, such as polyethylene glycol and polypropylene glycol, can suppress the penetration of pest repellent components into the skin and reduce irritation to the skin. May be.

Further, in order to improve the feeling of use (such as the smooth feeling of the coated surface), inorganic powders such as silicic anhydride, talc and kaolin and organic powders such as modified starch and silk fiber powder may be blended. Furthermore, UV absorption such as dipotassium glycyrrhizinate, allantoin, alkyltrimethylammonium chloride, tocopherol acetate, camphor, etc., paraaminobenzoic acid, amylsalicynate, octylcinnamate, octyl methoxycinnamate, 2,4-dihydroxybenzophenone, etc. It is also possible to add antiperspirants, stabilizers, fragrances, etc., such as aluminum sulfate, ultraviolet scattering agent, aluminum sulfate, chlorohydroxyaluminum, and zinc phenolsulfonate, as long as they do not affect the stability of the pest repellent composition for human body. Is possible.

The human body pest repellent thus prepared is water-based and highly safe against fire, and has little irritation to the human body. There are no particular restrictions on the form of use, but specific examples of use include non-aerosol sprays and forms filled in roll-on type containers, forms impregnated into sheet base materials such as nonwoven fabrics, and liquefied petroleum Of course, gas, dimethyl ether, compressed gas (nitrogen gas, compressed air, etc.) or the like can be used as a propellant to form an aerosol agent, and the applicable range is extremely wide.

The skin penetration inhibitor of the pest repellent component of the present invention is blended in such a human body pest repellent, but it suppresses the penetration of the pest repellent component into the skin, against mosquitoes, gnats, sand flies, house dust mites, bedbugs, etc. Since the sustainability of the pest repellent effect can be improved, it is very useful for controlling bite damage. And the practical use of the penetration control method to the skin of the insect repellent component using this is also very high.

Next, based on specific examples and test examples, the penetration inhibitor for the pest repellent component of the present invention and the method for suppressing the penetration of the pest repellent component into the skin will be described in more detail.

As a pest repellent component, 5.0 g of icaridin is uniformly dissolved in 55.0 g of brewed ethanol, and then 40.0 g of desalted deep sea water (electrical conductivity: 3.8 mS / m) is added to repel the pest for human bodies. An agent was obtained.
This pest repellent composition for human bodies was uniformly clear even when stored in a thermostatic bath at 5 ° C. and 40 ° C. for 1 month. Next, the pest repellent for human body was filled into a pressure-accumulating pump container and used. After applying and spreading about 1 mL on the back of the hand, the state of the coated surface after 1 minute was observed, and there was no stickiness and a refreshing feel. In addition, since the pest repellent for human body contains a penetration inhibitor for pest repellent components into the skin, the pest repellent effect of the application part lasted for up to about 10 hours, and during that time, it was not bothered by pests such as mosquitoes .

According to Example 1, various human pest repellents shown in Table 1 were prepared, and the following tests were conducted.
(1) Feeling of use After about 1 mL was applied to the back of the hand and spread, the applied surface after 1 minute was touched with a fingertip to evaluate the feel. The results are shown in Table 1 as ◯ (with a refreshing feeling), Δ (with a slight stickiness), and × (with a sticky feeling and rough skin).
(2) Pest repellent effect test About 3 mL was applied to the arm of the examiner's hand, and it was sown in an outdoor test site where many aedes were present, and the time until the mosquito stopped on the arm was measured. The test was conducted four times with different testers, and the average duration of the pest repellent effect was determined. The results are shown in Table 1, ◎ (9 hours or more), ○ (7-9 hours),
Δ (6 to 7 hours), x (less than 6 hours).

As a result of the test, an inhibitor for penetration of the pest repellent component of the present invention into the skin, that is, natural mineral water having an electric conductivity of 1.5 mS / m to 30 mS / m, preferably 2.5 mS / m to 15 mS / m. The formulated pest repellent for human body was applied to the back of the hand and put to practical use. With a refreshing feeling without stickiness, penetration of the pest repellent component into the skin was suppressed and the proportion remaining on the skin increased. It was confirmed that the pest repellent effect was also excellent in persistence.
As natural mineral water, water containing desalted deep ocean water is preferable, and as a pest repellent component, IR3535, diet or p-menthane-3, 8 is considered in combination with natural mineral water. It has also been found that icaridin is more suitable than the diol for the purpose of the present invention.
On the other hand, Comparative Examples 1 to 5 (pest repellents containing deionized water and water whose electrical conductivity is out of the range of 1.5 mS / m to 30 mS / m) have a feeling of use and a sustained pest repellent effect. Somewhat inferior.
Furthermore, from the comparison between the product 10 of the present invention and Comparative Example 6, even when deionized water is used, it is possible to increase the blending amount of the pest repellent component and increase the sustainability of the pest repellent effect. Obviously, it may lead to a decrease and is not necessarily an effective method.

The agent for suppressing penetration of the pest repellent component into the skin and the method for suppressing penetration of the pest repellent component into the skin of the present invention may be applicable to pest repellent fields other than those for the human body.

Claims (7)

An agent for suppressing penetration of the pest repellent component into the skin, which is a natural mineral water blended with a pest repellent for human body containing a pest repellent component and having an electrical conductivity of 1.5 mS / m to 30 mS / m. The penetration inhibitor for skin according to claim 1, wherein the natural mineral water is water containing desalted deep ocean water. The pest repellent component includes 1-methylpropyl 2- (2-hydroxyethyl) -1-piperidinecarboxylate, ethyl 3- (Nn-butylacetamido) propionate, diet, and p-menthane-3,8- The penetration inhibitor for skin according to claim 1 or 2, which is one or more selected from diols. The penetration inhibitor for skin according to claim 3, wherein the insect repellent component is 1-methylpropyl 2- (2-hydroxyethyl) -1-piperidinecarboxylate. 5. The human body pest repellent further comprises one or more selected from alcohol compounds and / or glycol compounds having 2 to 6 carbon atoms. The skin penetration inhibitor as described. A method for suppressing penetration of the pest repellent component into the skin, wherein a natural mineral water having an electric conductivity of 1.5 mS / m to 30 mS / m is blended with a pest repellent for human body containing the pest repellent component. The method according to claim 6, wherein the natural mineral water is water containing desalted deep ocean water.