JP7228318B6 - 処置用化合物及び組成物、並びにその使用方法 - Google Patents

処置用化合物及び組成物、並びにその使用方法 Download PDF

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JP7228318B6
JP7228318B6 JP2019564529A JP2019564529A JP7228318B6 JP 7228318 B6 JP7228318 B6 JP 7228318B6 JP 2019564529 A JP2019564529 A JP 2019564529A JP 2019564529 A JP2019564529 A JP 2019564529A JP 7228318 B6 JP7228318 B6 JP 7228318B6
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alkyl
pharmaceutically acceptable
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JP2020520957A5 (enExample
JP2020520957A (ja
JP7228318B2 (ja
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ザック,マーク
ロメロ,エフ・アンソニー
チェン,ユン-シン
リ,ウェイ
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2019564529A 2017-05-22 2018-05-21 処置用化合物及び組成物、並びにその使用方法 Active JP7228318B6 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2017085277 2017-05-22
CNPCT/CN2017/085277 2017-05-22
US201862644784P 2018-03-19 2018-03-19
US62/644,784 2018-03-19
PCT/EP2018/063263 WO2018215390A1 (en) 2017-05-22 2018-05-21 Therapeutic compounds and compositions, and methods of use thereof

Publications (4)

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JP2020520957A JP2020520957A (ja) 2020-07-16
JP2020520957A5 JP2020520957A5 (enExample) 2021-07-26
JP7228318B2 JP7228318B2 (ja) 2023-02-24
JP7228318B6 true JP7228318B6 (ja) 2023-03-10

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JP2019564529A Active JP7228318B6 (ja) 2017-05-22 2018-05-21 処置用化合物及び組成物、並びにその使用方法

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US (3) US20180334465A1 (enExample)
EP (1) EP3630767A1 (enExample)
JP (1) JP7228318B6 (enExample)
CN (1) CN110678467B (enExample)
TW (1) TW201900648A (enExample)
WO (1) WO2018215390A1 (enExample)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
TW201720828A (zh) * 2015-11-23 2017-06-16 赫孚孟拉羅股份公司 治療性化合物及組合物以及其使用方法
TW201902896A (zh) 2017-05-22 2019-01-16 瑞士商赫孚孟拉羅股份公司 治療化合物及組合物及其使用方法
BR112021015616A2 (pt) * 2019-02-07 2021-11-09 Ventyx Biosciences Inc Ligantes de pseudoquinase tyk2
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
PH12021552998A1 (en) * 2019-06-18 2023-08-14 Hoffmann La Roche Pyrazolopyrimidine sulfone inhibitors of jak kinases and uses thereof
JP7682110B2 (ja) 2019-06-18 2025-05-23 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Jakキナーゼのテトラゾール置換ピラゾロピリミジン阻害剤及びその使用
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2022008283A1 (en) 2020-07-07 2022-01-13 Universitat Rovira I Virgili Reagents for the polyfluoroalkylthiolation of organic compounds and method for production thereof

Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2012532112A (ja) 2009-07-02 2012-12-13 ジェネンテック, インコーポレイテッド ピラゾロピリミジンjak阻害剤化合物及び方法
WO2017089390A1 (en) 2015-11-23 2017-06-01 F. Hoffmann-La Roche Ag Janus kinases inhibitors, compositions thereof and use thereof
WO2017140825A1 (en) 2016-02-18 2017-08-24 F. Hoffmann-La Roche Ag Therapeutic compounds, compositions and methods of use thereof

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AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
US5543523A (en) 1994-11-15 1996-08-06 Regents Of The University Of Minnesota Method and intermediates for the synthesis of korupensamines
JPH11508583A (ja) 1995-07-06 1999-07-27 ゼネカ・リミテッド ペプチド系のフィブロネクチン阻害薬
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
YU25500A (sh) 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
GB0028383D0 (en) 2000-11-21 2001-01-03 Novartis Ag Organic compounds
EP1241176A1 (en) 2001-03-16 2002-09-18 Pfizer Products Inc. Purine derivatives for the treatment of ischemia
DE60214428T2 (de) 2001-12-20 2007-09-20 Bayer Healthcare Ag 1, 4-dihydro-1, 4-diphenylpyridin-derivate
SE0302487D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
GB0502258D0 (en) 2005-02-03 2005-03-09 Argenta Discovery Ltd Compounds and their use
CA2727036C (en) 2008-06-20 2017-03-21 Genentech, Inc. Triazolopyridine jak inhibitor compounds and methods
EP2348860B1 (en) 2008-10-31 2015-05-27 Genentech, Inc. Pyrazolopyrimidine jak inhibitor compounds and methods
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
WO2014074775A1 (en) 2012-11-09 2014-05-15 Jacobus Pharmaceutical Company, Inc. Heteroaryl derivatives and uses thereof
HRP20210935T1 (hr) 2014-05-23 2021-08-06 F. Hoffmann - La Roche Ag Spojevi 5-kloro-2-difluorometoksifenil pirazolopirimidina koji predstavljaju inhibitore jak

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
JP2012532112A (ja) 2009-07-02 2012-12-13 ジェネンテック, インコーポレイテッド ピラゾロピリミジンjak阻害剤化合物及び方法
WO2017089390A1 (en) 2015-11-23 2017-06-01 F. Hoffmann-La Roche Ag Janus kinases inhibitors, compositions thereof and use thereof
JP6914933B2 (ja) 2015-11-23 2021-08-04 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft ヤヌスキナーゼ、並びにその組成物及びその使用
WO2017140825A1 (en) 2016-02-18 2017-08-24 F. Hoffmann-La Roche Ag Therapeutic compounds, compositions and methods of use thereof

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Publication number Publication date
WO2018215390A1 (en) 2018-11-29
CN110678467B (zh) 2023-06-13
US20180334465A1 (en) 2018-11-22
CN110678467A (zh) 2020-01-10
US20220024945A1 (en) 2022-01-27
JP2020520957A (ja) 2020-07-16
US20200062779A1 (en) 2020-02-27
TW201900648A (zh) 2019-01-01
EP3630767A1 (en) 2020-04-08
JP7228318B2 (ja) 2023-02-24

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