CN110678467B - 治疗化合物和组合物及其使用方法 - Google Patents

治疗化合物和组合物及其使用方法 Download PDF

Info

Publication number
CN110678467B
CN110678467B CN201880033713.4A CN201880033713A CN110678467B CN 110678467 B CN110678467 B CN 110678467B CN 201880033713 A CN201880033713 A CN 201880033713A CN 110678467 B CN110678467 B CN 110678467B
Authority
CN
China
Prior art keywords
compounds
compound
group
pharmaceutically acceptable
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201880033713.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN110678467A (zh
Inventor
M·扎克
F·A·罗梅罗
Y-X·成
李伟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN110678467A publication Critical patent/CN110678467A/zh
Application granted granted Critical
Publication of CN110678467B publication Critical patent/CN110678467B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201880033713.4A 2017-05-22 2018-05-21 治疗化合物和组合物及其使用方法 Expired - Fee Related CN110678467B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2017/085277 2017-05-22
CN2017085277 2017-05-22
US201862644784P 2018-03-19 2018-03-19
US62/644,784 2018-03-19
PCT/EP2018/063263 WO2018215390A1 (en) 2017-05-22 2018-05-21 Therapeutic compounds and compositions, and methods of use thereof

Publications (2)

Publication Number Publication Date
CN110678467A CN110678467A (zh) 2020-01-10
CN110678467B true CN110678467B (zh) 2023-06-13

Family

ID=62486555

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880033713.4A Expired - Fee Related CN110678467B (zh) 2017-05-22 2018-05-21 治疗化合物和组合物及其使用方法

Country Status (6)

Country Link
US (3) US20180334465A1 (enExample)
EP (1) EP3630767A1 (enExample)
JP (1) JP7228318B6 (enExample)
CN (1) CN110678467B (enExample)
TW (1) TW201900648A (enExample)
WO (1) WO2018215390A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201720828A (zh) * 2015-11-23 2017-06-16 赫孚孟拉羅股份公司 治療性化合物及組合物以及其使用方法
JP7256757B2 (ja) 2017-05-22 2023-04-12 エフ． ホフマン－ラ ロシュ アーゲー 処置用化合物及び組成物、並びにその使用方法
SG11202108619SA (en) * 2019-02-07 2021-09-29 Ventyx Biosciences Inc Tyk2 pseudokinase ligands
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
JP7657740B2 (ja) * 2019-06-18 2025-04-07 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｊａｋキナーゼのピラゾロピリミジンスルホン阻害剤およびその使用
CN114026096B (zh) * 2019-06-18 2025-02-07 豪夫迈·罗氏有限公司 四唑取代的吡唑并嘧啶类jak激酶抑制剂及其用途
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
EP4178950A1 (en) 2020-07-07 2023-05-17 Universitat Rovira I Virgili Reagents for the polyfluoroalkylthiolation of organic compounds and method for production thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108368116A (zh) * 2015-11-23 2018-08-03 豪夫迈·罗氏有限公司 Janus激酶抑制剂、其组合物及用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
US5543523A (en) 1994-11-15 1996-08-06 Regents Of The University Of Minnesota Method and intermediates for the synthesis of korupensamines
JPH11508583A (ja) 1995-07-06 1999-07-27 ゼネカ・リミテッド ペプチド系のフィブロネクチン阻害薬
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
YU25500A (sh) 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
GB0028383D0 (en) 2000-11-21 2001-01-03 Novartis Ag Organic compounds
EP1241176A1 (en) 2001-03-16 2002-09-18 Pfizer Products Inc. Purine derivatives for the treatment of ischemia
AU2002361992A1 (en) 2001-12-20 2003-07-09 Bayer Aktiengesellschaft 1,4-dihydro-1,4-diphenylpyridine derivatives
SE0302487D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
GB0502258D0 (en) 2005-02-03 2005-03-09 Argenta Discovery Ltd Compounds and their use
AU2009259853A1 (en) 2008-06-20 2009-12-23 Genentech, Inc. Triazolopyridine JAK inhibitor compounds and methods
BRPI0914404A2 (pt) 2008-10-31 2019-03-06 Genentech Inc "compostos, composição farmacêutica e método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak quinase em um paciente"
UA110324C2 (en) * 2009-07-02 2015-12-25 Genentech Inc Jak inhibitory compounds based on pyrazolo pyrimidine
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
HUE047441T2 (hu) 2012-11-09 2020-04-28 Medicines For Malaria Venture Mmv Heteroaril-származékok és alkamazásaik
HRP20210935T1 (hr) 2014-05-23 2021-08-06 F. Hoffmann - La Roche Ag Spojevi 5-kloro-2-difluorometoksifenil pirazolopirimidina koji predstavljaju inhibitore jak
WO2017140825A1 (en) 2016-02-18 2017-08-24 F. Hoffmann-La Roche Ag Therapeutic compounds, compositions and methods of use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108368116A (zh) * 2015-11-23 2018-08-03 豪夫迈·罗氏有限公司 Janus激酶抑制剂、其组合物及用途

Also Published As

Publication number Publication date
US20220024945A1 (en) 2022-01-27
CN110678467A (zh) 2020-01-10
US20200062779A1 (en) 2020-02-27
JP7228318B6 (ja) 2023-03-10
WO2018215390A1 (en) 2018-11-29
JP2020520957A (ja) 2020-07-16
EP3630767A1 (en) 2020-04-08
US20180334465A1 (en) 2018-11-22
JP7228318B2 (ja) 2023-02-24
TW201900648A (zh) 2019-01-01

Similar Documents

Publication Publication Date Title
RU2769696C2 (ru) Терапевтические соединения и композиции и способы их применения
JP7228318B6 (ja) 処置用化合物及び組成物、並びにその使用方法
WO2017089390A1 (en) Janus kinases inhibitors, compositions thereof and use thereof
CN114026096B (zh) 四唑取代的吡唑并嘧啶类jak激酶抑制剂及其用途
US20230206644A1 (en) Pyrazolopyrimidine compounds as jak inhibitors
CN114008050B (zh) Jak激酶的吡唑并嘧啶芳基醚抑制剂及其用途
EP3596072B1 (en) Pyrazolochlorophenyl compounds, compositions and methods of use thereof
CN114008051B (zh) Jak激酶的吡唑并嘧啶砜抑制剂及其用途
HK40019825A (en) Therapeutic compounds and compositions, and methods of use thereof
HK40029259A (en) Pyrazolopyrimidine compounds as jak inhibitors
HK40067224A (en) Pyrazolopyrimidine aryl ether inhibitors of jak kinases and uses thereof
HK40019824A (en) Therapeutic compounds and compositions, and methods of use thereof
HK40019824B (en) Therapeutic compounds and compositions, and methods of use thereof
HK40017827A (en) Pyrazolochlorophenyl compounds, compositions and methods of use thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40019825

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20230613

CF01 Termination of patent right due to non-payment of annual fee