JP7222987B2 - 抗ｒｏｒ１抗体とその作製及び使用方法 - Google Patents

抗ｒｏｒ１抗体とその作製及び使用方法 Download PDF

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JP7222987B2
JP7222987B2 JP2020520426A JP2020520426A JP7222987B2 JP 7222987 B2 JP7222987 B2 JP 7222987B2 JP 2020520426 A JP2020520426 A JP 2020520426A JP 2020520426 A JP2020520426 A JP 2020520426A JP 7222987 B2 JP7222987 B2 JP 7222987B2
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seq
antigen
cancer
acid sequence
binding fragment
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JP2020529863A (ja
JP2020529863A5 (enExample
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オーレ オルセン，
フィル タン，
ドン シア，
デイビッド ジェリーマン，
ブライアン コヴァセヴィチ，
ビル ブレイディ，
ブレア レンショー，
ゼレン ガオ，
イ ツー，
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Systimmune Inc
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Systimmune Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020520426A 2017-06-25 2018-06-22 抗ｒｏｒ１抗体とその作製及び使用方法 Active JP7222987B2 (ja)

Priority Applications (1)

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JP2023015342A JP7464764B2 (ja) 2017-06-25 2023-02-03 抗ｒｏｒ１抗体とその作製及び使用方法

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US201762524557P 2017-06-25 2017-06-25
US201762524558P 2017-06-25 2017-06-25
US201762524554P 2017-06-25 2017-06-25
US62/524,554 2017-06-25
US62/524,558 2017-06-25
US62/524,557 2017-06-25
US201762545603P 2017-08-15 2017-08-15
US62/545,603 2017-08-15
US201762551035P 2017-08-28 2017-08-28
US201762551032P 2017-08-28 2017-08-28
US201762551065P 2017-08-28 2017-08-28
US62/551,032 2017-08-28
US62/551,035 2017-08-28
US62/551,065 2017-08-28
PCT/US2018/039152 WO2019005636A2 (en) 2017-06-25 2018-06-22 ANTI-ROR1 ANTIBODIES AND METHODS OF PREPARATION AND USE

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JP2020529863A JP2020529863A (ja) 2020-10-15
JP2020529863A5 JP2020529863A5 (enExample) 2022-01-17
JP7222987B2 true JP7222987B2 (ja) 2023-02-15

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JP2020520426A Active JP7222987B2 (ja) 2017-06-25 2018-06-22 抗ｒｏｒ１抗体とその作製及び使用方法
JP2020520428A Active JP7323513B2 (ja) 2017-06-25 2018-06-22 抗４－１ｂｂ抗体とその作製及び使用方法
JP2023015342A Active JP7464764B2 (ja) 2017-06-25 2023-02-03 抗ｒｏｒ１抗体とその作製及び使用方法

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JP2023015342A Active JP7464764B2 (ja) 2017-06-25 2023-02-03 抗ｒｏｒ１抗体とその作製及び使用方法

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US (2) US11987635B2 (enExample)
EP (2) EP3645741A4 (enExample)
JP (3) JP7222987B2 (enExample)
CN (7) CN116731180A (enExample)
WO (2) WO2019005638A2 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201710838D0 (en) 2017-07-05 2017-08-16 Ucl Business Plc Bispecific antibodies
GB201710835D0 (en) 2017-07-05 2017-08-16 Ucl Business Plc ROR1 Antibodies
GB201710836D0 (en) 2017-07-05 2017-08-16 Ucl Business Plc ROR1 Car T-Cells
WO2020018964A1 (en) 2018-07-20 2020-01-23 Fred Hutchinson Cancer Research Center Compositions and methods for controlled expression of antigen-specific receptors
KR20220140534A (ko) * 2020-01-30 2022-10-18 온크터널 테라퓨틱스 인코포레이티드 암 치료를 위한 egfr 억제제와 ror1 억제제의 조합
KR20220148209A (ko) * 2020-02-28 2022-11-04 상하이 헨리우스 바이오테크, 인크. 항cd137 작제물 및 그 용도
CN111499746B (zh) * 2020-04-28 2020-11-24 优睿赛思(武汉)生物科技有限公司 一种针对人白介素-2的高亲和力兔单克隆抗体及其应用
US20230235055A1 (en) * 2020-07-28 2023-07-27 The Board Of Regents Of The University Of Texas System Monoclonal antibodies against lilrb1 for diagnostic and therapeutic use
TWI818308B (zh) * 2020-09-03 2023-10-11 大陸商和鉑醫藥（上海）有限責任公司 標靶ｒｏｒ１的抗體或其抗原結合片段及製備方法和應用
CA3172530A1 (en) 2021-02-25 2022-09-01 Spencer PARK Ror1 targeting chimeric antigen receptor
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
US12545716B2 (en) 2021-07-19 2026-02-10 Immunome, Inc. Immunoconjugates and methods
WO2023077026A1 (en) 2021-10-28 2023-05-04 Lyell Immunopharma, Inc. Methods for culturing cells expressing ror1-binding protein
CN116333139B (zh) * 2021-12-22 2026-02-27 上海复旦张江生物医药股份有限公司 一种抗fda0128抗体、其制备方法和应用
WO2024064958A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024064952A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells overexpressing c-jun
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
CN120813375A (zh) 2023-01-30 2025-10-17 凯玛布有限公司 抗体
CN118745226B (zh) * 2023-06-07 2026-02-17 浙江博锐生物制药有限公司 抗ror1抗体及其应用
CN117467004B (zh) * 2023-10-09 2024-06-21 武汉爱博泰克生物科技有限公司 抗人钙网膜蛋白的兔单克隆抗体及其应用
WO2025106600A2 (en) * 2023-11-15 2025-05-22 Systimmune, Inc. Anti-dll3 antibody and method of making and using thereof
CN117624355B (zh) * 2023-11-30 2024-05-14 无锡傲锐东源生物科技有限公司 一种抗人乙酰化tau274兔单克隆抗体及其应用
CN117736330B (zh) * 2024-01-24 2024-05-17 上海沙砾生物科技有限公司 肿瘤坏死因子超家族受体9的特异性抗原结合蛋白及其应用
WO2025217398A1 (en) 2024-04-10 2025-10-16 Lyell Immunopharma, Inc. Methods for culturing cells with improved culture medium
CN118930648B (zh) * 2024-08-22 2025-02-28 武汉爱博泰克生物科技有限公司 抗人pax8蛋白的兔单克隆抗体、抗体偶联物及其应用
CN121851161B (zh) * 2026-03-16 2026-05-08 南京诺唯赞医疗科技有限公司 α-syn特异性抗体及其在帕金森辅助诊断试剂盒中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130251642A1 (en) 2010-12-01 2013-09-26 The United States of America, as represented by the secretary, Department of Heath and Human Servi Chimeric rabbit/human ror1 antibodies
JP2015532644A (ja) 2012-08-24 2015-11-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｒｏｒ１癌の治療および転移の阻害に使用するための抗体およびワクチン

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DE60232895D1 (de) * 2001-10-09 2009-08-20 Mayo Foundation Verwendung von agonistischen 4-1bb antikörpern zur erhöhung der immunantwort
AR046094A1 (es) * 2003-10-10 2005-11-23 Bristol Myers Squibb Co Anticuerpos completamente humanos contra 4-1bb humano
WO2006029220A2 (en) * 2004-09-08 2006-03-16 Ohio State University Research Foundation Combination therapy with anti-ctla4 and anti-4-1bb antibodies
AU2015252014B2 (en) * 2009-04-23 2017-03-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-human ror1 antibodies
SG10201912092VA (en) * 2010-09-09 2020-02-27 Pfizer 4-1bb binding molecules
GB201020995D0 (en) * 2010-12-10 2011-01-26 Bioinvent Int Ab Biological materials and uses thereof
CA2858350A1 (en) * 2011-01-14 2013-07-19 The Regents Of The University Of California Therapeutic antibodies against ror-1 protein and methods for use of same
US9624298B2 (en) * 2011-11-28 2017-04-18 Merck Patent Gmbh Anti-PD-L1 antibodies and uses thereof
CA2935748A1 (en) * 2014-02-25 2015-09-03 Immunomedics, Inc. Humanized rfb4 anti-cd22 antibody
DK3237005T3 (en) * 2014-12-22 2024-11-18 Systimmune Inc Bispecific tetravalent antibodies and methods of making and using thereof
CN104817642B (zh) * 2015-05-04 2018-03-27 北京百普赛斯生物科技有限公司 抗人ror1单克隆抗体及其制备方法与应用
JP2021519289A (ja) * 2018-03-27 2021-08-10 システィミューン， インク．Ｓｙｓｔｉｍｍｕｎｅ， Ｉｎｃ． ガイダンス及びナビゲーションコントロール蛋白質の生産及び使用方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130251642A1 (en) 2010-12-01 2013-09-26 The United States of America, as represented by the secretary, Department of Heath and Human Servi Chimeric rabbit/human ror1 antibodies
JP2015532644A (ja) 2012-08-24 2015-11-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｒｏｒ１癌の治療および転移の阻害に使用するための抗体およびワクチン

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Clin. Cancer Res.，2017年06月15日，Vol.23, No.12，pp.3061-3071

Also Published As

Publication number Publication date
CN110799539B (zh) 2023-08-15
WO2019005638A2 (en) 2019-01-03
CN110869389B (zh) 2023-07-28
CN116731180A (zh) 2023-09-12
EP3645742A4 (en) 2021-07-14
WO2019005636A2 (en) 2019-01-03
JP7464764B2 (ja) 2024-04-09
US20210277109A1 (en) 2021-09-09
CN110869389A (zh) 2020-03-06
CN110799539A (zh) 2020-02-14
EP3645741A4 (en) 2021-08-25
JP2020531043A (ja) 2020-11-05
US20210188989A1 (en) 2021-06-24
CN116789832A (zh) 2023-09-22
JP2020529863A (ja) 2020-10-15
US11518815B2 (en) 2022-12-06
EP3645742B1 (en) 2026-04-29
EP3645741A2 (en) 2020-05-06
CN116925227A (zh) 2023-10-24
EP3645742A2 (en) 2020-05-06
JP2023065391A (ja) 2023-05-12
CN116731179A (zh) 2023-09-12
JP7323513B2 (ja) 2023-08-08
CN116769035A (zh) 2023-09-19
US11987635B2 (en) 2024-05-21

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