JP7200093B2 - がん治療用ｔｌｒ９アゴニストを用いた免疫調節 - Google Patents

がん治療用ｔｌｒ９アゴニストを用いた免疫調節 Download PDF

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JP7200093B2
JP7200093B2 JP2019514720A JP2019514720A JP7200093B2 JP 7200093 B2 JP7200093 B2 JP 7200093B2 JP 2019514720 A JP2019514720 A JP 2019514720A JP 2019514720 A JP2019514720 A JP 2019514720A JP 7200093 B2 JP7200093 B2 JP 7200093B2
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JP2019529415A (ja
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アグラワル，スディール
ワン，ダーチン
ジャン，ウェイン
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アイデラ・ファーマシューティカルズ，インコーポレーテッド
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2019514720A 2016-09-15 2017-09-15 がん治療用ｔｌｒ９アゴニストを用いた免疫調節 Active JP7200093B2 (ja)

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JP2021170043A JP2022009200A (ja) 2016-09-15 2021-10-18 がん治療用ｔｌｒ９アゴニストを用いた免疫調節

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US201662394845P 2016-09-15 2016-09-15
US62/394,845 2016-09-15
US201762486738P 2017-04-18 2017-04-18
US62/486,738 2017-04-18
PCT/US2017/051742 WO2018053242A1 (en) 2016-09-15 2017-09-15 Immune modulation with tlr9 agonists for cancer treatment

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KR (1) KR20190096936A (enExample)
CN (1) CN110114057A (enExample)
AU (1) AU2017325981A1 (enExample)
CA (1) CA3036978A1 (enExample)
IL (2) IL292658A (enExample)
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US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
IL292658A (en) 2016-09-15 2022-07-01 Idera Pharmaceuticals Inc Immune modulation with tlr9 agonists for cancer treatment
KR102576042B1 (ko) 2016-10-11 2023-09-07 아게누스 인코포레이티드 항-lag-3 항체 및 이의 사용 방법
RS64576B1 (sr) 2017-05-01 2023-10-31 Agenus Inc Anti-tigit antitela i postupci njihove primene
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
AU2017414149B2 (en) 2017-05-19 2025-05-15 Wuxi Biologics (Shanghai) Co., Ltd. Novel monoclonal antibodies to cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)
CN113226366A (zh) * 2018-10-18 2021-08-06 艾德拉药物股份有限公司 用于治疗癌症的tlr9调节剂
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JP2023517330A (ja) * 2020-03-09 2023-04-25 ダイナヴァックス テクノロジーズ コーポレイション 破傷風、ジフテリア、および百日咳に対する能動的追加免疫付与
EP4216930A4 (en) * 2020-09-22 2024-08-07 Trisalus Life Sciences, Inc. CANCER THERAPY WITH TOLL-LIKE RECEPTOR AGONISTS
TW202304965A (zh) 2021-05-04 2023-02-01 美商艾吉納斯公司 抗ｔｉｇｉｔ抗體、抗ｃｄ９６抗體及其使用方法

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Title
Ｃａｎｃｅｒ Ｉｍｍｕｎｏｌ． Ｒｅｓ． （Ｊａｎ ２０１６） ｖｏｌ．４， Ｉｓｓｕｅ １ Ｓｕｐｐｌ．， Ａｂｓｔｒａｃｔ Ｂ１５３
Ｍｏｄｕｌａｔｉｏｎ ｏｆ Ｃｈｅｃｋｐｏｉｎｔ Ｅｘｐｒｅｓｓｉｏｎ ｉｎ Ｔｕｍｏｒ Ｍｉｃｒｏｅｎｖｉｒｏｎｍｅｎｔ ｂｙ Ｉｎｔｒａｔｕｍｏｒａｌ Ａｄｍｉｎｉｓｔｒａｔｉｏｎ ｏｆ ａ Ｎｏｖｅｌ ＴＬＲ９ Ａｇｏｎｉｓｔ： Ｒａｔｉｏｎａｌｅ ｆｏｒ Ｃｏｍｂｉｎａｔｉｏｎ Ｔｈｅｒａｐｙ， ＣＲＩ－ＣＩＭＴ－ＥＡＴＩ－ＡＡＣＲ Ｔｈｅ Ｉｎａｕｇｕｒａｌ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｃａｎｃｅｒ Ｉｍｍｕｎｏｔｈｅｒａｐｙ Ｃｏｎｆｅｒｅｎｃｅ， Ｎｅｗ Ｙｏｒｋ， ＮＹ， Ｓｅｐｔｅｍｂｅｒ １６－１９， ２０１５， ［ｒｅｔｒｉｅｖｅｄ ｏｎ ２０２０－１２－０３］， ＜ｈｔｔｐｓ：／／ｗｗｗ．ｉｄｅｒａｐｈａｒｍａ．ｃｏｍ／ｗｐ－ｃｏｎｔｅｎｔ／ｕｐｌｏａｄｓ／２０１５／０９／ｉｄｅｒａ＿ａａｃｒ＿２０１５＿ｃｈｅｃｋｐｏｉｎｔ＿ｆｉｎａｌ．ｐｄｆ＞
ＮＣＴ０２６４４９６７ Ａ Ｓｔｕｄｙ ｔｏ Ａｓｓｅｓｓ ｔｈｅ Ｓａｆｅｔｙａｎｄ Ｅｆｆｉｃａｃｙ ｏｆ Ｉｎｔｒａｔｕｍｏｒａｌ ＩＭＯ－２１２５ ｉｎ Ｃｏｍｂｉｎａｔｉｏｎ Ｗｉｔｈ Ｉｐｉｌｉｍｕｍａｂ ｏｒＰｅｍｂｒｏｌｉｚｕｍａｂ ｉｎ Ｐａｔｉｅｎｔｓ Ｗｉｔｈ Ｍｅｔａｓｔａｔｉｃ Ｍｅｌａｎｏｍａ， ＣｌｉｎｉｃａｌＴｒｉａｌｓ．ｇｏｖ， ［ｏｎｌｉｎｅ］，２０１６－０６－０２， ［ｒｅｔｒｉｅｖｅｄ ｏｎ ２０２０－１２－０３］， ＜ｈｔｔｐｓ：／／ｃｌｉｎｉｃａｌｔｒｉａｌｓ．ｇｏｖ／ｃｔ２／ｈｉｓｔｏｒｙ／ＮＣＴ０２６４４９６７？Ｖ＿４＝Ｖｉｅｗ＃ＳｔｕｄｙＰａｇｅＴｏｐ＞

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US10835550B2 (en) 2020-11-17
IL265370B (en) 2022-06-01
US10772907B2 (en) 2020-09-15
US20180125877A1 (en) 2018-05-10
AU2017325981A1 (en) 2019-04-11
MX2019002925A (es) 2019-09-05
US20210052625A1 (en) 2021-02-25
US11224611B2 (en) 2022-01-18
JP2019529415A (ja) 2019-10-17
CA3036978A1 (en) 2018-03-22
US10463686B2 (en) 2019-11-05
US20200054663A1 (en) 2020-02-20
US20200138848A1 (en) 2020-05-07
KR20190096936A (ko) 2019-08-20
EP3512499A4 (en) 2020-08-05
EP3512499A1 (en) 2019-07-24
US20210038630A1 (en) 2021-02-11
IL292658A (en) 2022-07-01
JP2022009200A (ja) 2022-01-14
US20220088054A1 (en) 2022-03-24
IL265370A (en) 2019-05-30
WO2018053242A1 (en) 2018-03-22

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