JP7199736B2 - モルホリニルピリドン化合物 - Google Patents
モルホリニルピリドン化合物 Download PDFInfo
- Publication number
- JP7199736B2 JP7199736B2 JP2020510087A JP2020510087A JP7199736B2 JP 7199736 B2 JP7199736 B2 JP 7199736B2 JP 2020510087 A JP2020510087 A JP 2020510087A JP 2020510087 A JP2020510087 A JP 2020510087A JP 7199736 B2 JP7199736 B2 JP 7199736B2
- Authority
- JP
- Japan
- Prior art keywords
- trifluoromethyl
- pharmaceutically acceptable
- acceptable salt
- methylmorpholin
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 Morpholinyl pyridone compound Chemical class 0.000 title claims description 28
- 150000001875 compounds Chemical class 0.000 claims description 128
- 239000000203 mixture Substances 0.000 claims description 52
- 150000003839 salts Chemical class 0.000 claims description 51
- 206010028980 Neoplasm Diseases 0.000 claims description 35
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 28
- 201000011510 cancer Diseases 0.000 claims description 24
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 17
- 125000001153 fluoro group Chemical group F* 0.000 claims description 14
- 125000005843 halogen group Chemical group 0.000 claims description 14
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 14
- 239000001257 hydrogen Substances 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 11
- 238000011282 treatment Methods 0.000 claims description 11
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 10
- 229910052736 halogen Inorganic materials 0.000 claims description 9
- 150000002367 halogens Chemical class 0.000 claims description 9
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 8
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 239000003085 diluting agent Substances 0.000 claims description 7
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 7
- 125000004076 pyridyl group Chemical group 0.000 claims description 7
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 7
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 6
- 206010005003 Bladder cancer Diseases 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 6
- 208000026310 Breast neoplasm Diseases 0.000 claims description 6
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 6
- 206010009944 Colon cancer Diseases 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 6
- 108090000790 Enzymes Proteins 0.000 claims description 6
- 208000032612 Glial tumor Diseases 0.000 claims description 6
- 206010018338 Glioma Diseases 0.000 claims description 6
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 6
- 206010025323 Lymphomas Diseases 0.000 claims description 6
- 206010033128 Ovarian cancer Diseases 0.000 claims description 6
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 6
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 6
- 206010060862 Prostate cancer Diseases 0.000 claims description 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 6
- 206010038389 Renal cancer Diseases 0.000 claims description 6
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims description 6
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 6
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 6
- 239000002246 antineoplastic agent Substances 0.000 claims description 6
- 201000010881 cervical cancer Diseases 0.000 claims description 6
- 208000029742 colonic neoplasm Diseases 0.000 claims description 6
- 201000010982 kidney cancer Diseases 0.000 claims description 6
- 208000032839 leukemia Diseases 0.000 claims description 6
- 201000007270 liver cancer Diseases 0.000 claims description 6
- 208000014018 liver neoplasm Diseases 0.000 claims description 6
- 201000005202 lung cancer Diseases 0.000 claims description 6
- 208000020816 lung neoplasm Diseases 0.000 claims description 6
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 6
- 201000002528 pancreatic cancer Diseases 0.000 claims description 6
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims description 6
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 6
- 208000023275 Autoimmune disease Diseases 0.000 claims description 5
- 208000036142 Viral infection Diseases 0.000 claims description 5
- 125000002883 imidazolyl group Chemical group 0.000 claims description 5
- 208000027866 inflammatory disease Diseases 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 125000002757 morpholinyl group Chemical group 0.000 claims description 5
- 230000004770 neurodegeneration Effects 0.000 claims description 5
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 5
- 230000009385 viral infection Effects 0.000 claims description 5
- 125000006677 (C1-C3) haloalkoxy group Chemical group 0.000 claims description 4
- KIRRPVVLWZDEOM-UHFFFAOYSA-N 4-(3-methylmorpholin-4-yl)-6-[4-(2-methylpyrazol-3-yl)sulfonyl-2-(trifluoromethyl)piperazin-1-yl]-1H-pyridin-2-one Chemical compound CC1N(CCOC1)C1=CC(NC(=C1)N1C(CN(CC1)S(=O)(=O)C=1N(N=CC=1)C)C(F)(F)F)=O KIRRPVVLWZDEOM-UHFFFAOYSA-N 0.000 claims description 4
- YAGDPINTXNUJFA-UHFFFAOYSA-N 4-(3-methylmorpholin-4-yl)-6-[4-(oxolan-3-ylsulfonyl)-2-(trifluoromethyl)piperazin-1-yl]-1H-pyridin-2-one Chemical compound CC1N(CCOC1)C1=CC(NC(=C1)N1C(CN(CC1)S(=O)(=O)C1COCC1)C(F)(F)F)=O YAGDPINTXNUJFA-UHFFFAOYSA-N 0.000 claims description 4
- LTTGFQYAQYEYHW-UHFFFAOYSA-N 4-(3-methylmorpholin-4-yl)-6-[4-methylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-1H-pyridin-2-one Chemical compound CC1N(CCOC1)C1=CC(NC(=C1)N1C(CN(CC1)S(=O)(=O)C)C(F)(F)F)=O LTTGFQYAQYEYHW-UHFFFAOYSA-N 0.000 claims description 4
- FKHNSGHHGRJGMU-UHFFFAOYSA-N 4-(3-methylmorpholin-4-yl)-6-[4-pyrrolidin-1-ylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-1H-pyridin-2-one Chemical compound CC1N(CCOC1)C1=CC(NC(=C1)N1C(CN(CC1)S(=O)(=O)N1CCCC1)C(F)(F)F)=O FKHNSGHHGRJGMU-UHFFFAOYSA-N 0.000 claims description 4
- YLNDUJZNLZBUIQ-UHFFFAOYSA-N 6-[4-(2-methoxyethylsulfonyl)-2-(trifluoromethyl)piperazin-1-yl]-4-(3-methylmorpholin-4-yl)-1H-pyridin-2-one Chemical compound COCCS(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)N1C(COCC1)C)C(F)(F)F YLNDUJZNLZBUIQ-UHFFFAOYSA-N 0.000 claims description 4
- LMMZDANJUDIECD-UHFFFAOYSA-N 6-[4-(4-fluorophenyl)sulfonyl-2-(trifluoromethyl)piperazin-1-yl]-4-(3-methylmorpholin-4-yl)-1H-pyridin-2-one Chemical compound FC1=CC=C(C=C1)S(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)N1C(COCC1)C)C(F)(F)F LMMZDANJUDIECD-UHFFFAOYSA-N 0.000 claims description 4
- AYEISBMTIDMDIW-UHFFFAOYSA-N 6-[4-(5-fluoropyridin-3-yl)sulfonyl-2-(trifluoromethyl)piperazin-1-yl]-4-(3-methylmorpholin-4-yl)-1H-pyridin-2-one Chemical compound FC=1C=C(C=NC=1)S(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)N1C(COCC1)C)C(F)(F)F AYEISBMTIDMDIW-UHFFFAOYSA-N 0.000 claims description 4
- MCOXRIXWEFCOLO-UHFFFAOYSA-N 6-[4-[(4-fluorophenyl)methylsulfonyl]-2-(trifluoromethyl)piperazin-1-yl]-4-(3-methylmorpholin-4-yl)-1H-pyridin-2-one Chemical compound FC1=CC=C(C=C1)CS(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)N1C(COCC1)C)C(F)(F)F MCOXRIXWEFCOLO-UHFFFAOYSA-N 0.000 claims description 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 4
- BFZZOZQOAVINFN-UHFFFAOYSA-N N,N-dimethyl-4-[4-(3-methylmorpholin-4-yl)-6-oxo-1H-pyridin-2-yl]-3-(trifluoromethyl)piperazine-1-sulfonamide Chemical compound CN(S(=O)(=O)N1CC(N(CC1)C=1NC(C=C(C=1)N1C(COCC1)C)=O)C(F)(F)F)C BFZZOZQOAVINFN-UHFFFAOYSA-N 0.000 claims description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 4
- 125000002971 oxazolyl group Chemical group 0.000 claims description 4
- 125000003386 piperidinyl group Chemical group 0.000 claims description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 238000001959 radiotherapy Methods 0.000 claims description 4
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 3
- 201000003733 ovarian melanoma Diseases 0.000 claims description 3
- BPXSDXXWOWIEGU-UHFFFAOYSA-N 4-(3-methylmorpholin-4-yl)-6-[4-methylsulfonyl-2-(trifluoromethyl)phenyl]-1H-pyridin-2-one Chemical compound CC1N(CCOC1)C1=CC(NC(=C1)C1=C(C=C(C=C1)S(=O)(=O)C)C(F)(F)F)=O BPXSDXXWOWIEGU-UHFFFAOYSA-N 0.000 claims description 2
- GEQMLAFCKWRJLD-UHFFFAOYSA-N 4-(3-methylmorpholin-4-yl)-6-[4-morpholin-4-ylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-1H-pyridin-2-one Chemical compound CC1N(CCOC1)C1=CC(NC(=C1)N1C(CN(CC1)S(=O)(=O)N1CCOCC1)C(F)(F)F)=O GEQMLAFCKWRJLD-UHFFFAOYSA-N 0.000 claims description 2
- VGAYOERTTXJDOP-UHFFFAOYSA-N 4-(3-methylmorpholin-4-yl)-6-[4-piperidin-1-ylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-1H-pyridin-2-one Chemical compound CC1N(CCOC1)C1=CC(NC(=C1)N1C(CN(CC1)S(=O)(=O)N1CCCCC1)C(F)(F)F)=O VGAYOERTTXJDOP-UHFFFAOYSA-N 0.000 claims description 2
- YRXRLABGSILYCG-UHFFFAOYSA-N 6-[4-(1,2-dimethylimidazol-4-yl)sulfonyl-2-(trifluoromethyl)piperazin-1-yl]-4-(3-methylmorpholin-4-yl)-1H-pyridin-2-one Chemical compound CN1C(=NC(=C1)S(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)N1C(COCC1)C)C(F)(F)F)C YRXRLABGSILYCG-UHFFFAOYSA-N 0.000 claims description 2
- JAVRYPHODLVYTQ-UHFFFAOYSA-N 6-[4-(1-methylcyclopropyl)sulfonyl-2-(trifluoromethyl)piperazin-1-yl]-4-(3-methylmorpholin-4-yl)-1H-pyridin-2-one Chemical compound CC1(CC1)S(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)N1C(COCC1)C)C(F)(F)F JAVRYPHODLVYTQ-UHFFFAOYSA-N 0.000 claims description 2
- VUXZPNNEUUVZLC-UHFFFAOYSA-N 6-[4-cyclopropylsulfonyl-2-(trifluoromethyl)piperazin-1-yl]-4-(3-methylmorpholin-4-yl)-1H-pyridin-2-one Chemical compound C1(CC1)S(=O)(=O)N1CC(N(CC1)C1=CC(=CC(N1)=O)N1C(COCC1)C)C(F)(F)F VUXZPNNEUUVZLC-UHFFFAOYSA-N 0.000 claims description 2
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- HJXFEQOSKUTUOT-UHFFFAOYSA-N N,N-dimethyl-4-[4-(3-methylmorpholin-4-yl)-6-oxo-1H-pyridin-2-yl]-3-(trifluoromethyl)benzenesulfonamide Chemical compound CN(S(=O)(=O)C1=CC(=C(C=C1)C=1NC(C=C(C=1)N1C(COCC1)C)=O)C(F)(F)F)C HJXFEQOSKUTUOT-UHFFFAOYSA-N 0.000 claims description 2
- 239000002168 alkylating agent Substances 0.000 claims description 2
- 229940100198 alkylating agent Drugs 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
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- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims description 2
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- 239000000047 product Substances 0.000 description 36
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 30
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
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- Immunology (AREA)
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- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022198452A JP2023021268A (ja) | 2017-08-23 | 2022-12-13 | モルホリニルピリドン化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17187567.7 | 2017-08-23 | ||
| EP17187567 | 2017-08-23 | ||
| PCT/EP2018/072791 WO2019038390A1 (en) | 2017-08-23 | 2018-08-23 | MORPHOLINYLPYRIDONE COMPOUNDS |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2022198452A Division JP2023021268A (ja) | 2017-08-23 | 2022-12-13 | モルホリニルピリドン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020531485A JP2020531485A (ja) | 2020-11-05 |
| JP2020531485A5 JP2020531485A5 (OSRAM) | 2021-09-30 |
| JP7199736B2 true JP7199736B2 (ja) | 2023-01-06 |
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| JP2020510087A Active JP7199736B2 (ja) | 2017-08-23 | 2018-08-23 | モルホリニルピリドン化合物 |
| JP2022198452A Ceased JP2023021268A (ja) | 2017-08-23 | 2022-12-13 | モルホリニルピリドン化合物 |
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| JP2022198452A Ceased JP2023021268A (ja) | 2017-08-23 | 2022-12-13 | モルホリニルピリドン化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11560374B2 (OSRAM) |
| EP (2) | EP4056569A1 (OSRAM) |
| JP (2) | JP7199736B2 (OSRAM) |
| KR (1) | KR102732013B1 (OSRAM) |
| CN (3) | CN111108102B (OSRAM) |
| AU (2) | AU2018320419B2 (OSRAM) |
| CY (1) | CY1125117T1 (OSRAM) |
| DK (1) | DK3672962T3 (OSRAM) |
| ES (1) | ES2910157T3 (OSRAM) |
| HR (1) | HRP20220497T1 (OSRAM) |
| HU (1) | HUE058661T2 (OSRAM) |
| IL (3) | IL302077A (OSRAM) |
| LT (1) | LT3672962T (OSRAM) |
| PL (1) | PL3672962T3 (OSRAM) |
| PT (1) | PT3672962T (OSRAM) |
| RS (1) | RS63109B1 (OSRAM) |
| SI (1) | SI3672962T1 (OSRAM) |
| SM (1) | SMT202200169T1 (OSRAM) |
| TW (2) | TW202348601A (OSRAM) |
| WO (1) | WO2019038390A1 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023550641A (ja) * | 2020-11-25 | 2023-12-04 | デシフェラ・ファーマシューティカルズ，エルエルシー | ウイルス感染症の治療に使用するためのｖｓｐ３４阻害剤としてのモルホリノ誘導体 |
| CN117241800A (zh) * | 2020-11-25 | 2023-12-15 | 德西费拉制药有限责任公司 | Vps34抑制剂的抗病毒活性 |
| WO2022115562A1 (en) | 2020-11-25 | 2022-06-02 | Deciphera Pharmaceuticals, Llc | Morpholino derivatives as vsp34 inhibitors for use in the treatment of a viral infection |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015525236A (ja) | 2012-06-22 | 2015-09-03 | サノフイ | 置換モルホリンを含む新規な２，３−ジヒドロ−１Ｈ−イミダゾ｛１，２−ａ｝ピリミジン−５−オンおよびこの１，２，３，４−テトラヒドロピリミド｛１，２−ａ｝ピリミジン−６−オン誘導体、その調製およびその製薬学的使用 |
| WO2017009751A1 (en) | 2015-07-15 | 2017-01-19 | Pfizer Inc. | Pyrimidine derivatives |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7622486B2 (en) * | 2004-09-23 | 2009-11-24 | Reddy Us Therapeutics, Inc. | Pyridine compounds, process for their preparation and compositions containing them |
| WO2011058478A1 (en) * | 2009-11-16 | 2011-05-19 | Pfizer Inc. | Substituted triazolopyrimidines as pde8 inhibitors |
| MX2013007336A (es) | 2010-12-21 | 2013-08-01 | Novartis Ag | Compuestos de bi-heteroarilo como inhibidores de vps34. |
| WO2012085244A1 (fr) * | 2010-12-23 | 2012-06-28 | Sanofi | Derives de pyrimidinone, leur preparation et leur utilisation pharmaceutique |
| FR2969612B1 (fr) * | 2010-12-23 | 2013-02-08 | Sanofi Aventis | Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique |
| GB201120317D0 (en) | 2011-11-24 | 2012-01-04 | Queen Mary & Westfield College | Screening method |
| WO2015030057A1 (ja) * | 2013-08-29 | 2015-03-05 | 富士フイルム株式会社 | 新規なモルホリン誘導体またはその塩 |
| CN105916503B (zh) | 2014-01-14 | 2020-04-14 | 米伦纽姆医药公司 | 杂芳基化合物和其用途 |
| JP2017502092A (ja) | 2014-01-14 | 2017-01-19 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヘテロアリール及びその使用 |
| MA39823A (fr) | 2014-04-03 | 2018-01-09 | Janssen Pharmaceutica Nv | Dérivés de pyridine macrocyclique |
| MA39822A (fr) | 2014-04-03 | 2018-02-06 | Janssen Pharmaceutica Nv | Dérivés de pyrimidine bicycle |
| CN108884067B (zh) * | 2016-02-19 | 2021-01-08 | 思普瑞特生物科学公司 | 可用于治疗癌症和糖尿病的6-杂环基-4-吗啉-4-基吡啶-2-酮化合物 |
| PT3416945T (pt) * | 2016-02-19 | 2020-09-11 | Sprint Bioscience Ab | Compostos de 6-aril-4-(morfolin-4-il)-1h-piridina-2-ona úteis para o tratamento do cancro e da diabetes |
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2018
- 2018-08-23 EP EP22153292.2A patent/EP4056569A1/en not_active Withdrawn
- 2018-08-23 PT PT187591052T patent/PT3672962T/pt unknown
- 2018-08-23 TW TW112116474A patent/TW202348601A/zh unknown
- 2018-08-23 WO PCT/EP2018/072791 patent/WO2019038390A1/en not_active Ceased
- 2018-08-23 CN CN201880060742.XA patent/CN111108102B/zh active Active
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- 2018-08-23 DK DK18759105.2T patent/DK3672962T3/da active
- 2018-08-23 SI SI201830624T patent/SI3672962T1/sl unknown
- 2018-08-23 SM SM20220169T patent/SMT202200169T1/it unknown
- 2018-08-23 US US16/639,902 patent/US11560374B2/en active Active
- 2018-08-23 EP EP18759105.2A patent/EP3672962B1/en active Active
- 2018-08-23 KR KR1020207007564A patent/KR102732013B1/ko active Active
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- 2018-08-23 JP JP2020510087A patent/JP7199736B2/ja active Active
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- 2018-08-23 AU AU2018320419A patent/AU2018320419B2/en active Active
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- 2018-08-23 CN CN202310448700.6A patent/CN116444510A/zh active Pending
- 2018-08-23 CN CN202310448740.0A patent/CN116462674A/zh active Pending
- 2018-08-23 TW TW107129499A patent/TWI803511B/zh not_active IP Right Cessation
- 2018-08-23 ES ES18759105T patent/ES2910157T3/es active Active
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2020
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2022
- 2022-04-14 CY CY20221100283T patent/CY1125117T1/el unknown
- 2022-04-25 IL IL292489A patent/IL292489B2/en unknown
- 2022-12-13 JP JP2022198452A patent/JP2023021268A/ja not_active Ceased
- 2022-12-19 US US18/084,208 patent/US20230234949A1/en not_active Abandoned
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2023
- 2023-12-22 AU AU2023285995A patent/AU2023285995A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015525236A (ja) | 2012-06-22 | 2015-09-03 | サノフイ | 置換モルホリンを含む新規な２，３−ジヒドロ−１Ｈ−イミダゾ｛１，２−ａ｝ピリミジン−５−オンおよびこの１，２，３，４−テトラヒドロピリミド｛１，２−ａ｝ピリミジン−６−オン誘導体、その調製およびその製薬学的使用 |
| WO2017009751A1 (en) | 2015-07-15 | 2017-01-19 | Pfizer Inc. | Pyrimidine derivatives |
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