JP7198755B2 - 抗体エピトープ - Google Patents

抗体エピトープ Download PDF

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JP7198755B2
JP7198755B2 JP2019533144A JP2019533144A JP7198755B2 JP 7198755 B2 JP7198755 B2 JP 7198755B2 JP 2019533144 A JP2019533144 A JP 2019533144A JP 2019533144 A JP2019533144 A JP 2019533144A JP 7198755 B2 JP7198755 B2 JP 7198755B2
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tnfα
compound
antibody
trimer
binding
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JP2020504604A (ja
JP2020504604A5 (https=
Inventor
デイビッド グリフィフィシズ ローソン、アラステア
ジョン ライトウッド、ダニエル
ジェイン ムンロ、レベッカ
フィリップ オコンネル、ジェイムズ
ロバート ポーター、ジョン
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Sanofi SA
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
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  • Biochemistry (AREA)
  • Dermatology (AREA)
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JP2019533144A 2016-12-21 2017-12-13 抗体エピトープ Active JP7198755B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022150888A JP2022184988A (ja) 2016-12-21 2022-09-22 抗体エピトープ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1621907.3A GB201621907D0 (en) 2016-12-21 2016-12-21 Antibody epitope
GB1621907.3 2016-12-21
PCT/EP2017/082685 WO2018114538A1 (en) 2016-12-21 2017-12-13 Antibody epitope

Related Child Applications (1)

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JP2022150888A Division JP2022184988A (ja) 2016-12-21 2022-09-22 抗体エピトープ

Publications (3)

Publication Number Publication Date
JP2020504604A JP2020504604A (ja) 2020-02-13
JP2020504604A5 JP2020504604A5 (https=) 2021-01-28
JP7198755B2 true JP7198755B2 (ja) 2023-01-04

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JP2022150888A Withdrawn JP2022184988A (ja) 2016-12-21 2022-09-22 抗体エピトープ

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US (3) US11174311B2 (https=)
EP (1) EP3559031A1 (https=)
JP (2) JP7198755B2 (https=)
CN (1) CN110291106A (https=)
CA (1) CA3047193A1 (https=)
GB (1) GB201621907D0 (https=)
WO (1) WO2018114538A1 (https=)

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GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy

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