JP7197755B2 - 循環血清マイクロｒｎａバイオマーカー及び方法 - Google Patents

循環血清マイクロｒｎａバイオマーカー及び方法 Download PDF

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JP7197755B2
JP7197755B2 JP2018560445A JP2018560445A JP7197755B2 JP 7197755 B2 JP7197755 B2 JP 7197755B2 JP 2018560445 A JP2018560445 A JP 2018560445A JP 2018560445 A JP2018560445 A JP 2018560445A JP 7197755 B2 JP7197755 B2 JP 7197755B2
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mirnas
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サイモン・ガイア・モラー
インドラニル・バサク
ケタン・パティル
ジャン・ピーター・ラーセン
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St Johns University
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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JP2018560445A 2016-02-05 2017-02-03 循環血清マイクロｒｎａバイオマーカー及び方法 Active JP7197755B2 (ja)

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US201662291619P 2016-02-05 2016-02-05
US62/291,619 2016-02-05
PCT/US2017/016412 WO2017136662A1 (en) 2016-02-05 2017-02-03 Circulating serum microrna biomarkers and methods for determining parkinson's disease

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JP2019506183A JP2019506183A (ja) 2019-03-07
JP2019506183A5 JP2019506183A5 (enExample) 2020-01-23
JP7197755B2 true JP7197755B2 (ja) 2022-12-28

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US (2) US11499184B2 (enExample)
EP (2) EP3411500B9 (enExample)
JP (1) JP7197755B2 (enExample)
ES (1) ES2947634T3 (enExample)
WO (1) WO2017136662A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3642366B1 (en) * 2017-06-19 2023-11-15 St. John's University Circulating serum microrna biomarkers and methods for alzheimer's disease diagnosis
US20220042099A1 (en) * 2018-10-18 2022-02-10 Quadrant Biosciences Inc. Molecular and functional characterization of early-stage parkinson's disease and treatments therein
US12486536B2 (en) 2019-03-11 2025-12-02 Ochsner Health System MicroRNA regulatory network as biomarkers of seizure in patients with spontaneous intracerebral hemorrhage
JP7650467B2 (ja) * 2019-04-17 2025-03-25 京都府公立大学法人 自己免疫疾患及び／又は炎症性疾患の判定方法、並びに炎症性疾患及び／又は自己免疫疾患の予防及び／又は治療剤
CN111073973A (zh) * 2019-12-10 2020-04-28 石河子大学 一种用于早期诊断2型糖尿病的microRNA序列及其应用
EP4151752A4 (en) 2020-05-14 2025-08-13 Kao Corp PARKINSON'S DISEASE DETECTION METHOD
WO2022165024A1 (en) * 2021-01-27 2022-08-04 Beth Israel Deaconess Medical Center Electrophoretic mobility shift as a molecular beacon-based readout for mirna detection
WO2023050642A1 (zh) * 2021-09-29 2023-04-06 南京凡亦达生物科技有限公司 甲胎蛋白或癌胚抗原联合基因标志物在肿瘤诊断中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013036936A1 (en) 2011-09-09 2013-03-14 Van Andel Research Institute Microrna biomarkers for diagnosing parkinson's disease
WO2014018650A1 (en) 2012-07-25 2014-01-30 Rush University Medical Center Mirnas as novel therapeutic targets and diagnostic biomarkers for parkinson's disease

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
CN104903468B (zh) 2012-11-16 2019-04-23 萨尔大学 用于帕金森氏病的新诊断MiRNA标志物
WO2014179765A2 (en) * 2013-05-02 2014-11-06 Thomas Jefferson University Novel human mirnas for use in diagnosis, prognosis and therapy of human conditions and diseases
WO2015091892A1 (en) * 2013-12-19 2015-06-25 Comprehensive Biomarker Center Gmbh Mirnas as non-invasive biomarkers for parkinson's disease
US20150197809A1 (en) * 2014-01-13 2015-07-16 Trustees Of Boston University Methods and assays relating to huntingtons disease and parkinson's disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013036936A1 (en) 2011-09-09 2013-03-14 Van Andel Research Institute Microrna biomarkers for diagnosing parkinson's disease
WO2014018650A1 (en) 2012-07-25 2014-01-30 Rush University Medical Center Mirnas as novel therapeutic targets and diagnostic biomarkers for parkinson's disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AMENE SAGHAZADEH，MICRORNA MACHINERY IN PARKINSON'S DISEASE: A PLATFORM FOR NEURODEGENERATIVE DISEASES，EXPERT REVIEW OF NEUROTHERAPEUTICS，英国，2015年11月17日，PAGE(S): 1 - 27，https://www.ncbi.nlm.nih.gov/pubmed/26574782
SAPANA SHINDE，BIOFLUID-BASED MICRORNA BIOMARKERS FOR PARKINSON'S DISEASE: AN OVERVIEW AND UPDATE，AIMS MEDICAL SCIENCE，2015年01月01日，VOL:2,NR:1，PAGE(S):15-25，http://scholarworks.gvsu.edu/cgi/viewcontent.cgi?article=1003&context=bms_articles

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US20200354768A1 (en) 2020-11-12
EP3411500A1 (en) 2018-12-12
EP3411500B1 (en) 2023-06-07
US11499184B2 (en) 2022-11-15
WO2017136662A1 (en) 2017-08-10
EP3411500C0 (en) 2023-06-07
JP2019506183A (ja) 2019-03-07
EP3411500B9 (en) 2023-10-04
US20230323442A1 (en) 2023-10-12
EP3985130A1 (en) 2022-04-20
ES2947634T3 (es) 2023-08-14
WO2017136662A4 (en) 2017-08-31

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