JP7197363B2 - ヌクレアーゼを使用するヒト神経幹細胞のゲノム編集 - Google Patents

ヌクレアーゼを使用するヒト神経幹細胞のゲノム編集 Download PDF

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JP7197363B2
JP7197363B2 JP2018554450A JP2018554450A JP7197363B2 JP 7197363 B2 JP7197363 B2 JP 7197363B2 JP 2018554450 A JP2018554450 A JP 2018554450A JP 2018554450 A JP2018554450 A JP 2018554450A JP 7197363 B2 JP7197363 B2 JP 7197363B2
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neural stem
stem cells
dna
human neural
genetically modified
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JP2019511240A (ja
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マシュー エイチ． ポーテウス，
エリック ジェイ． キルドベック，
ダニエル ピー． デバー，
ジョセフ ティー． クラーク，
アン ツカモト，
ノブコ ウチダ，
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Leland Stanford Junior University
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Leland Stanford Junior University
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JP2018554450A 2016-04-14 2017-04-13 ヌクレアーゼを使用するヒト神経幹細胞のゲノム編集 Active JP7197363B2 (ja)

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US201662322652P 2016-04-14 2016-04-14
US62/322,652 2016-04-14
PCT/US2017/027504 WO2017180926A1 (en) 2016-04-14 2017-04-13 Genome editing of human neural stem cells using nucleases

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JP2019511240A JP2019511240A (ja) 2019-04-25
JP2019511240A5 JP2019511240A5 (https=) 2020-05-14
JP7197363B2 true JP7197363B2 (ja) 2022-12-27

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US (2) US20170298348A1 (https=)
EP (1) EP3443085B1 (https=)
JP (1) JP7197363B2 (https=)
CN (1) CN109312308A (https=)
AU (2) AU2017250683A1 (https=)
CA (1) CA3020181A1 (https=)
SG (1) SG11201808920RA (https=)
WO (1) WO2017180926A1 (https=)

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US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
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US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
US9340799B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College MRNA-sensing switchable gRNAs
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US20150165054A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting caspase-9 point mutations
WO2016022363A2 (en) 2014-07-30 2016-02-11 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
JP7109784B2 (ja) 2015-10-23 2022-08-01 プレジデント アンド フェローズ オブ ハーバード カレッジ 遺伝子編集のための進化したＣａｓ９蛋白質
KR102547316B1 (ko) 2016-08-03 2023-06-23 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 아데노신 핵염기 편집제 및 그의 용도
US11661590B2 (en) 2016-08-09 2023-05-30 President And Fellows Of Harvard College Programmable CAS9-recombinase fusion proteins and uses thereof
US11542509B2 (en) 2016-08-24 2023-01-03 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
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WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
EP3592853A1 (en) 2017-03-09 2020-01-15 President and Fellows of Harvard College Suppression of pain by gene editing
JP2020510038A (ja) 2017-03-09 2020-04-02 プレジデント アンド フェローズ オブ ハーバード カレッジ がんワクチン
JP2020510439A (ja) 2017-03-10 2020-04-09 プレジデント アンド フェローズ オブ ハーバード カレッジ シトシンからグアニンへの塩基編集因子
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KR20250107288A (ko) 2017-10-16 2025-07-11 더 브로드 인스티튜트, 인코퍼레이티드 아데노신 염기 편집제의 용도
WO2019118949A1 (en) 2017-12-15 2019-06-20 The Broad Institute, Inc. Systems and methods for predicting repair outcomes in genetic engineering
EP3797160A1 (en) 2018-05-23 2021-03-31 The Broad Institute Inc. Base editors and uses thereof
US12522807B2 (en) 2018-07-09 2026-01-13 The Broad Institute, Inc. RNA programmable epigenetic RNA modifiers and uses thereof
WO2020092453A1 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Nucleobase editors comprising geocas9 and uses thereof
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
JP7657726B2 (ja) 2019-03-19 2025-04-07 ザ ブロード インスティテュート，インコーポレーテッド 編集ヌクレオチド配列を編集するための方法および組成物
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CN110075319A (zh) * 2019-04-29 2019-08-02 白涛 一种抗遗传病生物导弹
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WO2021163327A1 (en) * 2020-02-11 2021-08-19 University Of Virginia Patent Foundation Compositions and methods for treating and/or preventing ocular disorders
JP2023517230A (ja) * 2020-03-11 2023-04-24 リモーター セラピューティクス インコーポレイテッド 中枢神経系全体にわたってタンパク質を散在させるための方法および材料
DE112021002672T5 (de) 2020-05-08 2023-04-13 President And Fellows Of Harvard College Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
KR20230019156A (ko) * 2020-06-02 2023-02-07 카탈렌트 파마 솔루션즈, 엘엘씨 유전자 삽입을 위한 다수의 도크들이 있는 세포주
CN111925998A (zh) * 2020-06-09 2020-11-13 广州再生医学与健康广东省实验室 模拟SARS-CoV-2感染的系统及其制备方法与应用
WO2022163770A1 (ja) * 2021-01-28 2022-08-04 国立研究開発法人理化学研究所 ゲノム編集ツールの評価方法
WO2023102712A1 (zh) * 2021-12-07 2023-06-15 深圳市先康达生命科学有限公司 一种基因生物制剂及其制备方法和应用

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EP3443085B1 (en) 2022-09-14
CN109312308A (zh) 2019-02-05
US20170298348A1 (en) 2017-10-19
EP3443085A1 (en) 2019-02-20
EP3443085A4 (en) 2019-09-25
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AU2023208065A1 (en) 2023-08-17
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US20230250423A1 (en) 2023-08-10
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