JP7197363B2 - ヌクレアーゼを使用するヒト神経幹細胞のゲノム編集 - Google Patents

ヌクレアーゼを使用するヒト神経幹細胞のゲノム編集 Download PDF

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JP7197363B2
JP7197363B2 JP2018554450A JP2018554450A JP7197363B2 JP 7197363 B2 JP7197363 B2 JP 7197363B2 JP 2018554450 A JP2018554450 A JP 2018554450A JP 2018554450 A JP2018554450 A JP 2018554450A JP 7197363 B2 JP7197363 B2 JP 7197363B2
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neural stem
stem cells
dna
human neural
genetically modified
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JP2019511240A (ja
JP2019511240A5 (enExample
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マシュー エイチ． ポーテウス，
エリック ジェイ． キルドベック，
ダニエル ピー． デバー，
ジョセフ ティー． クラーク，
アン ツカモト，
ノブコ ウチダ，
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Leland Stanford Junior University
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JP2018554450A 2016-04-14 2017-04-13 ヌクレアーゼを使用するヒト神経幹細胞のゲノム編集 Active JP7197363B2 (ja)

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US201662322652P 2016-04-14 2016-04-14
US62/322,652 2016-04-14
PCT/US2017/027504 WO2017180926A1 (en) 2016-04-14 2017-04-13 Genome editing of human neural stem cells using nucleases

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JP2019511240A JP2019511240A (ja) 2019-04-25
JP2019511240A5 JP2019511240A5 (enExample) 2020-05-14
JP7197363B2 true JP7197363B2 (ja) 2022-12-27

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US (2) US20170298348A1 (enExample)
EP (1) EP3443085B1 (enExample)
JP (1) JP7197363B2 (enExample)
CN (1) CN109312308A (enExample)
AU (2) AU2017250683A1 (enExample)
CA (1) CA3020181A1 (enExample)
SG (1) SG11201808920RA (enExample)
WO (1) WO2017180926A1 (enExample)

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US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US9340799B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College MRNA-sensing switchable gRNAs
US11053481B2 (en) 2013-12-12 2021-07-06 President And Fellows Of Harvard College Fusions of Cas9 domains and nucleic acid-editing domains
AU2015298571B2 (en) 2014-07-30 2020-09-03 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
US12043852B2 (en) 2015-10-23 2024-07-23 President And Fellows Of Harvard College Evolved Cas9 proteins for gene editing
KR20250103795A (ko) 2016-08-03 2025-07-07 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 아데노신 핵염기 편집제 및 그의 용도
CN109804066A (zh) 2016-08-09 2019-05-24 哈佛大学的校长及成员们 可编程cas9-重组酶融合蛋白及其用途
US11542509B2 (en) 2016-08-24 2023-01-03 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
AU2017342543B2 (en) 2016-10-14 2024-06-27 President And Fellows Of Harvard College AAV delivery of nucleobase editors
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CN111801345A (zh) 2017-07-28 2020-10-20 哈佛大学的校长及成员们 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
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AU2023208065A1 (en) 2023-08-17
US20230250423A1 (en) 2023-08-10
JP2019511240A (ja) 2019-04-25
EP3443085A1 (en) 2019-02-20
CN109312308A (zh) 2019-02-05
AU2017250683A1 (en) 2018-11-01
EP3443085B1 (en) 2022-09-14
EP3443085A4 (en) 2019-09-25
CA3020181A1 (en) 2017-10-19
WO2017180926A1 (en) 2017-10-19
SG11201808920RA (en) 2018-11-29
US20170298348A1 (en) 2017-10-19

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