JP7197363B2 - ヌクレアーゼを使用するヒト神経幹細胞のゲノム編集 - Google Patents

ヌクレアーゼを使用するヒト神経幹細胞のゲノム編集 Download PDF

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JP7197363B2
JP7197363B2 JP2018554450A JP2018554450A JP7197363B2 JP 7197363 B2 JP7197363 B2 JP 7197363B2 JP 2018554450 A JP2018554450 A JP 2018554450A JP 2018554450 A JP2018554450 A JP 2018554450A JP 7197363 B2 JP7197363 B2 JP 7197363B2
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neural stem
stem cells
dna
human neural
genetically modified
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JP2019511240A (ja
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マシュー エイチ． ポーテウス，
エリック ジェイ． キルドベック，
ダニエル ピー． デバー，
ジョセフ ティー． クラーク，
アン ツカモト，
ノブコ ウチダ，
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Leland Stanford Junior University
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JP2018554450A 2016-04-14 2017-04-13 ヌクレアーゼを使用するヒト神経幹細胞のゲノム編集 Active JP7197363B2 (ja)

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US201662322652P 2016-04-14 2016-04-14
US62/322,652 2016-04-14
PCT/US2017/027504 WO2017180926A1 (en) 2016-04-14 2017-04-13 Genome editing of human neural stem cells using nucleases

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JP2019511240A JP2019511240A (ja) 2019-04-25
JP2019511240A5 JP2019511240A5 (OSRAM) 2020-05-14
JP7197363B2 true JP7197363B2 (ja) 2022-12-27

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US (2) US20170298348A1 (OSRAM)
EP (1) EP3443085B1 (OSRAM)
JP (1) JP7197363B2 (OSRAM)
CN (1) CN109312308A (OSRAM)
AU (2) AU2017250683A1 (OSRAM)
CA (1) CA3020181A1 (OSRAM)
SG (1) SG11201808920RA (OSRAM)
WO (1) WO2017180926A1 (OSRAM)

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US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US9737604B2 (en) 2013-09-06 2017-08-22 President And Fellows Of Harvard College Use of cationic lipids to deliver CAS9
US9322037B2 (en) 2013-09-06 2016-04-26 President And Fellows Of Harvard College Cas9-FokI fusion proteins and uses thereof
US9068179B1 (en) 2013-12-12 2015-06-30 President And Fellows Of Harvard College Methods for correcting presenilin point mutations
US10077453B2 (en) 2014-07-30 2018-09-18 President And Fellows Of Harvard College CAS9 proteins including ligand-dependent inteins
EP3365356B1 (en) 2015-10-23 2023-06-28 President and Fellows of Harvard College Nucleobase editors and uses thereof
JP7231935B2 (ja) 2016-08-03 2023-03-08 プレジデント アンド フェローズ オブ ハーバード カレッジ アデノシン核酸塩基編集因子およびそれらの使用
EP3497214B1 (en) 2016-08-09 2023-06-28 President and Fellows of Harvard College Programmable cas9-recombinase fusion proteins and uses thereof
WO2018039438A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
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KR20240116572A (ko) 2017-03-23 2024-07-29 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
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AU2023208065A1 (en) 2023-08-17
EP3443085A1 (en) 2019-02-20
CA3020181A1 (en) 2017-10-19
AU2017250683A1 (en) 2018-11-01
EP3443085A4 (en) 2019-09-25
CN109312308A (zh) 2019-02-05
WO2017180926A1 (en) 2017-10-19
SG11201808920RA (en) 2018-11-29
JP2019511240A (ja) 2019-04-25
US20170298348A1 (en) 2017-10-19
US20230250423A1 (en) 2023-08-10
EP3443085B1 (en) 2022-09-14

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