JP7181186B2 - 電気穿孔を使用した、脂肪組織の低侵襲のｉｎ ｖｉｖｏトランスフェクションのための方法及び装置 - Google Patents

電気穿孔を使用した、脂肪組織の低侵襲のｉｎ ｖｉｖｏトランスフェクションのための方法及び装置 Download PDF

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JP7181186B2
JP7181186B2 JP2019515790A JP2019515790A JP7181186B2 JP 7181186 B2 JP7181186 B2 JP 7181186B2 JP 2019515790 A JP2019515790 A JP 2019515790A JP 2019515790 A JP2019515790 A JP 2019515790A JP 7181186 B2 JP7181186 B2 JP 7181186B2
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electrode
tissue
contact surface
fat
electrodes
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JP2020500039A (ja
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フィッシャー ポール
ブロデリック ケイト
マッコイ ジェイ
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イノビオ ファーマシューティカルズ，インコーポレイティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/042—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Surgical Instruments (AREA)
  • Electrotherapy Devices (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Prostheses (AREA)
JP2019515790A 2016-09-23 2017-09-22 電気穿孔を使用した、脂肪組織の低侵襲のｉｎ ｖｉｖｏトランスフェクションのための方法及び装置 Active JP7181186B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022151171A JP7448603B2 (ja) 2016-09-23 2022-09-22 電気穿孔を使用した、脂肪組織の低侵襲のｉｎ ｖｉｖｏトランスフェクションのための方法及び装置
JP2024029929A JP2024054418A (ja) 2016-09-23 2024-02-29 電気穿孔を使用した、脂肪組織の低侵襲のｉｎ ｖｉｖｏトランスフェクションのための方法及び装置

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662398932P 2016-09-23 2016-09-23
US62/398,932 2016-09-23
US201762480180P 2017-03-31 2017-03-31
US62/480,180 2017-03-31
PCT/US2017/052970 WO2018057900A1 (en) 2016-09-23 2017-09-22 Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation

Related Child Applications (1)

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JP2022151171A Division JP7448603B2 (ja) 2016-09-23 2022-09-22 電気穿孔を使用した、脂肪組織の低侵襲のｉｎ ｖｉｖｏトランスフェクションのための方法及び装置

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JP2020500039A JP2020500039A (ja) 2020-01-09
JP7181186B2 true JP7181186B2 (ja) 2022-11-30

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JP2022151171A Active JP7448603B2 (ja) 2016-09-23 2022-09-22 電気穿孔を使用した、脂肪組織の低侵襲のｉｎ ｖｉｖｏトランスフェクションのための方法及び装置
JP2024029929A Pending JP2024054418A (ja) 2016-09-23 2024-02-29 電気穿孔を使用した、脂肪組織の低侵襲のｉｎ ｖｉｖｏトランスフェクションのための方法及び装置

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JP2024029929A Pending JP2024054418A (ja) 2016-09-23 2024-02-29 電気穿孔を使用した、脂肪組織の低侵襲のｉｎ ｖｉｖｏトランスフェクションのための方法及び装置

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US (2) US11684777B2 (enExample)
EP (2) EP4238607A3 (enExample)
JP (3) JP7181186B2 (enExample)
KR (4) KR102313881B1 (enExample)
CN (2) CN117482374A (enExample)
AU (4) AU2017331263B2 (enExample)
CA (2) CA3204936A1 (enExample)
ES (1) ES2970888T3 (enExample)
MX (2) MX2019003335A (enExample)
WO (1) WO2018057900A1 (enExample)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
CN110741076A (zh) * 2017-04-26 2020-01-31 拉瓦塔解决方案股份有限公司 用于电穿孔的微电极技术
WO2022115609A1 (en) * 2020-11-25 2022-06-02 Flagship Pioneering, Inc. Adipogenic cell compositions and methods

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DE10032000A1 (de) 1999-07-01 2001-01-25 Medtronic Inc Medizinisches Gerät und Verfahren zur elektrophoretischen in situ Abgabe eines therapheutischen Wirkstoffs
US20030149451A1 (en) 2001-08-17 2003-08-07 Chomenky Victor I. Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US20050182462A1 (en) 2000-08-17 2005-08-18 Chornenky Victor I. Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
JP2008302254A (ja) 2008-09-24 2008-12-18 Terumo Corp 薬剤投与具
JP2009506870A (ja) 2005-09-07 2009-02-19 ザ ファウンドリー， インコーポレイテッド 皮下組織を治療する方法
JP2009506873A (ja) 2005-09-07 2009-02-19 ザ ファウンドリー， インコーポレイテッド 皮下構造を破壊するための装置および方法
JP2010524591A (ja) 2007-04-19 2010-07-22 ザ ファウンドリー， インコーポレイテッド 汗の産生を低減するための方法および装置
US20110009860A1 (en) 2000-08-17 2011-01-13 Chornenky Victor I Apparatus and Method for Reducing Subcutaneous Fat Deposits, Virtual Face Lift and Body Sculpturing by Electroporation
US20110112520A1 (en) 2009-11-11 2011-05-12 Invasix Corporation Method and device for fat treatment
US20110190659A1 (en) 2010-01-29 2011-08-04 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US20140277219A1 (en) 2013-03-14 2014-09-18 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
WO2015192018A1 (en) 2014-06-12 2015-12-17 Iowa Approach Inc. Method and apparatus for rapid and selective tissue ablation with cooling

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US6009345A (en) 1992-08-17 1999-12-28 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
US6216034B1 (en) * 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6778853B1 (en) * 1997-12-17 2004-08-17 University Of South Florida Electroporation device
JP2000139943A (ja) * 1998-09-02 2000-05-23 Olympus Optical Co Ltd 高周波処置具
JP3384750B2 (ja) * 1998-09-02 2003-03-10 オリンパス光学工業株式会社 高周波処置具
US6937890B2 (en) 1998-12-17 2005-08-30 University Of South Florida Nonpenetrating electroporation device
US20040204669A1 (en) * 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
JP3895633B2 (ja) 2002-04-19 2007-03-22 株式会社ザナヴィ・インフォマティクス 表示装置、情報処理装置、情報処理システム
JP2006293725A (ja) 2005-04-12 2006-10-26 Matsushita Electric Ind Co Ltd Ｌｓｉシステム向けデバッグ装置
US20060293725A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating fatty tissue sites using electroporation
US8133191B2 (en) 2006-02-16 2012-03-13 Syneron Medical Ltd. Method and apparatus for treatment of adipose tissue
JP5098024B2 (ja) * 2007-11-07 2012-12-12 有限会社リバー精工 内視鏡用高周波処置具
WO2009091578A1 (en) 2008-01-17 2009-07-23 Genetronics, Inc. Variable current density single needle electroporation system and method
KR101182330B1 (ko) 2010-04-07 2012-09-20 두산중공업 주식회사 터빈 속도 제어 시스템
US20130030430A1 (en) * 2011-07-29 2013-01-31 Stewart Mark T Intracardiac tools and methods for delivery of electroporation therapies
EP2941299B1 (en) * 2012-12-21 2018-10-17 University College Cork-National University of Ireland, Cork A thoracoscopic electroporation device with a suction head and with needle electrodes

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10032000A1 (de) 1999-07-01 2001-01-25 Medtronic Inc Medizinisches Gerät und Verfahren zur elektrophoretischen in situ Abgabe eines therapheutischen Wirkstoffs
US20050182462A1 (en) 2000-08-17 2005-08-18 Chornenky Victor I. Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US20110009860A1 (en) 2000-08-17 2011-01-13 Chornenky Victor I Apparatus and Method for Reducing Subcutaneous Fat Deposits, Virtual Face Lift and Body Sculpturing by Electroporation
US20030149451A1 (en) 2001-08-17 2003-08-07 Chomenky Victor I. Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
JP2009506870A (ja) 2005-09-07 2009-02-19 ザ ファウンドリー， インコーポレイテッド 皮下組織を治療する方法
JP2009506873A (ja) 2005-09-07 2009-02-19 ザ ファウンドリー， インコーポレイテッド 皮下構造を破壊するための装置および方法
JP2010524591A (ja) 2007-04-19 2010-07-22 ザ ファウンドリー， インコーポレイテッド 汗の産生を低減するための方法および装置
JP2008302254A (ja) 2008-09-24 2008-12-18 Terumo Corp 薬剤投与具
US20110112520A1 (en) 2009-11-11 2011-05-12 Invasix Corporation Method and device for fat treatment
US20110190659A1 (en) 2010-01-29 2011-08-04 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US20140277219A1 (en) 2013-03-14 2014-09-18 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
WO2015192018A1 (en) 2014-06-12 2015-12-17 Iowa Approach Inc. Method and apparatus for rapid and selective tissue ablation with cooling

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Publication number Publication date
KR20230155616A (ko) 2023-11-10
CA3037527A1 (en) 2018-03-29
AU2020250317A1 (en) 2020-11-12
JP2022188120A (ja) 2022-12-20
ES2970888T3 (es) 2024-05-31
US20200016400A1 (en) 2020-01-16
KR20220104077A (ko) 2022-07-25
EP4238607A3 (en) 2023-11-08
AU2017331263A1 (en) 2019-04-18
KR102313881B1 (ko) 2021-10-18
BR112019005740A2 (pt) 2019-06-18
EP4238607A2 (en) 2023-09-06
KR102423446B1 (ko) 2022-07-21
CN110022931B (zh) 2023-11-14
EP3515549B1 (en) 2023-11-22
AU2020250317B2 (en) 2023-01-05
US11684777B2 (en) 2023-06-27
AU2023202108A1 (en) 2023-05-04
KR20190055155A (ko) 2019-05-22
JP7448603B2 (ja) 2024-03-12
AU2025213675A1 (en) 2025-08-28
KR20210127797A (ko) 2021-10-22
CA3204936A1 (en) 2018-03-29
KR102599298B1 (ko) 2023-11-07
AU2017331263B2 (en) 2020-07-09
CN110022931A (zh) 2019-07-16
CN117482374A (zh) 2024-02-02
JP2024054418A (ja) 2024-04-16
JP2020500039A (ja) 2020-01-09
EP3515549A4 (en) 2020-06-10
MX2024007241A (es) 2024-06-26
US20230248965A1 (en) 2023-08-10
MX2019003335A (es) 2019-12-11
WO2018057900A1 (en) 2018-03-29
EP3515549A1 (en) 2019-07-31

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