JP7173969B2 - 点眼剤からの防腐剤除去 - Google Patents

点眼剤からの防腐剤除去 Download PDF

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JP7173969B2
JP7173969B2 JP2019529504A JP2019529504A JP7173969B2 JP 7173969 B2 JP7173969 B2 JP 7173969B2 JP 2019529504 A JP2019529504 A JP 2019529504A JP 2019529504 A JP2019529504 A JP 2019529504A JP 7173969 B2 JP7173969 B2 JP 7173969B2
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preservative
bak
removal device
solution
particles
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Japanese (ja)
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JP2020511179A5 (fr
JP2020511179A (ja
Inventor
アヌジ チョウハン
ポールバジャン セカル
フィリップ ジェイ． ディクソン
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ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/16—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/02—Loose filtering material, e.g. loose fibres
    • B01D39/04—Organic material, e.g. cellulose, cotton
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/16—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres
    • B01D39/1669—Cellular material
    • B01D39/1676—Cellular material of synthetic origin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0414—Surface modifiers, e.g. comprising ion exchange groups
    • B01D2239/0421—Rendering the filter material hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0442—Antimicrobial, antibacterial, antifungal additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/12—Special parameters characterising the filtering material
    • B01D2239/1208—Porosity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/12—Special parameters characterising the filtering material
    • B01D2239/1216—Pore size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/12—Special parameters characterising the filtering material
    • B01D2239/1241—Particle diameter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/12—Special parameters characterising the filtering material
    • B01D2239/1258—Permeability
JP2019529504A 2016-12-02 2017-12-04 点眼剤からの防腐剤除去 Active JP7173969B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022177369A JP2023024991A (ja) 2016-12-02 2022-11-04 点眼剤からの防腐剤除去

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662429384P 2016-12-02 2016-12-02
US62/429,384 2016-12-02
PCT/US2017/064513 WO2018102817A1 (fr) 2016-12-02 2017-12-04 Élimination d'un conservateur dans des gouttes pour les yeux

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022177369A Division JP2023024991A (ja) 2016-12-02 2022-11-04 点眼剤からの防腐剤除去

Publications (3)

Publication Number Publication Date
JP2020511179A JP2020511179A (ja) 2020-04-16
JP2020511179A5 JP2020511179A5 (fr) 2021-02-25
JP7173969B2 true JP7173969B2 (ja) 2022-11-16

Family

ID=62242208

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019529504A Active JP7173969B2 (ja) 2016-12-02 2017-12-04 点眼剤からの防腐剤除去
JP2022177369A Pending JP2023024991A (ja) 2016-12-02 2022-11-04 点眼剤からの防腐剤除去

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022177369A Pending JP2023024991A (ja) 2016-12-02 2022-11-04 点眼剤からの防腐剤除去

Country Status (12)

Country Link
US (2) US10786429B2 (fr)
EP (1) EP3547986A4 (fr)
JP (2) JP7173969B2 (fr)
KR (1) KR20190083366A (fr)
CN (2) CN112675032B (fr)
AU (1) AU2017366761B2 (fr)
BR (1) BR112019011099A2 (fr)
CA (1) CA3045906A1 (fr)
IL (2) IL300064A (fr)
MX (1) MX2019006445A (fr)
RU (1) RU2019120375A (fr)
WO (1) WO2018102817A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111132640B (zh) * 2017-09-25 2023-01-10 佛罗里达大学研究基金会股份有限公司 从含亲水药物的滴眼剂中除去防腐剂
TW202005623A (zh) * 2018-04-06 2020-02-01 美商蒂克利爾公司 用於輸送治療劑之系統及方法
TW202045190A (zh) * 2019-02-06 2020-12-16 美商蒂克利爾公司 自包含錯合劑之眼用調配物移除保存劑之系統及方法
JP2022526239A (ja) 2019-03-28 2022-05-24 ティアークリアー コープ． 眼科用製剤の流量制御のための装置および方法
MA55095A (fr) * 2019-05-02 2022-03-09 Tearclear Corp Élimination de conservateur de gouttes oculaires
AU2020405238A1 (en) 2019-12-19 2022-07-14 TearClear Corp. Preservative removal from eye drops
AU2021322232A1 (en) * 2020-08-05 2023-03-23 TearClear Corp. Systems and methods for preservative removal from ophthalmic formulations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010095478A1 (fr) 2009-02-20 2010-08-26 株式会社シード Lentille de contact en hydrogel à libération prolongée de médicament et procédé de libération de médicament mettant en oeuvre une lentille de contact en hydrogel à libération prolongée de médicament
WO2016025560A1 (fr) 2014-08-13 2016-02-18 University Of Florida Research Foundation, Inc. Extraction d'un conservateur à partir de collyres

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US5080800A (en) * 1990-01-08 1992-01-14 Ciba-Geigy Corporation Process for removing components from solutions
US5056689A (en) * 1990-01-08 1991-10-15 Ciba-Geigy Corporation Apparatus for removing components from solutions
US5496471A (en) * 1990-01-08 1996-03-05 Ciba-Geigy Corporation Apparatus for removing components from solutions
JP3468568B2 (ja) * 1993-03-31 2003-11-17 川田 武豊 携帯用液体浄化器
EP0631770B1 (fr) * 1993-06-25 1998-07-22 Alcon Cusi, S.A. Nouvelle utilisation de membranes polymères pour la distribution de solutions pharmaceutiques qui contiennent des composés d'ammonium quaternaire comme conservateur et distributeur de doses correspondant
ES2064286B1 (es) * 1993-06-25 1995-09-01 Cusi Lab Nueva aplicacion de membranas polimericas en la dispensacion de soluciones farmaceuticas que contienen compuestos de amonio cuaternario como conservadores y envase dosificador correspondiente.
US7611831B2 (en) * 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
JP2009516915A (ja) * 2005-11-21 2009-04-23 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 別個の材料が相互に貫通し合う網目構造の形成方法およびそのデバイス
WO2012015996A2 (fr) * 2010-07-29 2012-02-02 Allergan, Inc. Solutions de bimatoprost sans conservateur
WO2016032926A1 (fr) * 2014-08-26 2016-03-03 Novartis Ag Procédé pour appliquer un revêtement stable sur des lentilles de contact en hydrogel de silicone

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010095478A1 (fr) 2009-02-20 2010-08-26 株式会社シード Lentille de contact en hydrogel à libération prolongée de médicament et procédé de libération de médicament mettant en oeuvre une lentille de contact en hydrogel à libération prolongée de médicament
WO2016025560A1 (fr) 2014-08-13 2016-02-18 University Of Florida Research Foundation, Inc. Extraction d'un conservateur à partir de collyres

Also Published As

Publication number Publication date
KR20190083366A (ko) 2019-07-11
AU2017366761A1 (en) 2019-06-27
US10786429B2 (en) 2020-09-29
IL266904A (en) 2019-07-31
WO2018102817A1 (fr) 2018-06-07
BR112019011099A2 (pt) 2019-10-01
IL300064A (en) 2023-03-01
RU2019120375A (ru) 2021-01-11
CN112675032B (zh) 2022-03-29
IL266904B2 (en) 2023-07-01
EP3547986A1 (fr) 2019-10-09
JP2023024991A (ja) 2023-02-21
AU2017366761B2 (en) 2023-06-15
US20190247277A1 (en) 2019-08-15
CN112675032A (zh) 2021-04-20
MX2019006445A (es) 2019-08-21
US20200368107A1 (en) 2020-11-26
EP3547986A4 (fr) 2020-05-06
CA3045906A1 (fr) 2018-06-07
CN110167507A (zh) 2019-08-23
JP2020511179A (ja) 2020-04-16
IL266904B1 (en) 2023-03-01

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