JP7170666B2 - 操作された抗原受容体をコードする核酸分子及び阻害性核酸分子、並びにそれらの使用方法 - Google Patents

操作された抗原受容体をコードする核酸分子及び阻害性核酸分子、並びにそれらの使用方法 Download PDF

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JP7170666B2
JP7170666B2 JP2019561141A JP2019561141A JP7170666B2 JP 7170666 B2 JP7170666 B2 JP 7170666B2 JP 2019561141 A JP2019561141 A JP 2019561141A JP 2019561141 A JP2019561141 A JP 2019561141A JP 7170666 B2 JP7170666 B2 JP 7170666B2
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expression
nucleic acid
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JP2020518276A (ja
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ハックス，ジョアン
マーティン，アーロン
ジャンツ，デレック
ビアード，クレイトン
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プレシジョン バイオサイエンシズ，インク．
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    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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JP2019561141A 2017-05-08 2018-05-08 操作された抗原受容体をコードする核酸分子及び阻害性核酸分子、並びにそれらの使用方法 Active JP7170666B2 (ja)

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US201762503060P 2017-05-08 2017-05-08
US62/503,060 2017-05-08
US201762579460P 2017-10-31 2017-10-31
US62/579,460 2017-10-31
PCT/US2018/031674 WO2018208837A1 (en) 2017-05-08 2018-05-08 Nucleic acid molecules encoding an engineered antigen receptor and an inhibitory nucleic acid molecule and methods of use thereof

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US (3) US10745665B2 (https=)
EP (2) EP4029943A1 (https=)
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AU (1) AU2018266698A1 (https=)
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