JP7169979B2 - 補体関連腎症および肝線維症の候補治療剤の治療有効性を評価する方法 - Google Patents

補体関連腎症および肝線維症の候補治療剤の治療有効性を評価する方法 Download PDF

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JP7169979B2
JP7169979B2 JP2019546343A JP2019546343A JP7169979B2 JP 7169979 B2 JP7169979 B2 JP 7169979B2 JP 2019546343 A JP2019546343 A JP 2019546343A JP 2019546343 A JP2019546343 A JP 2019546343A JP 7169979 B2 JP7169979 B2 JP 7169979B2
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JP2020510827A (ja
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デバララジャ－ナラシンハ、キショル
モートン、ロリ
ルオ、イーファン
ファン、コン
ミーガー、カロリーナ
カサノバ、サラ
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Regeneron Pharmaceuticals Inc
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JP2019546343A 2017-02-27 2018-02-26 補体関連腎症および肝線維症の候補治療剤の治療有効性を評価する方法 Active JP7169979B2 (ja)

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Application Number Priority Date Filing Date Title
US201762464262P 2017-02-27 2017-02-27
US62/464,262 2017-02-27
US201762529916P 2017-07-07 2017-07-07
US62/529,916 2017-07-07
US201762583780P 2017-11-09 2017-11-09
US62/583,780 2017-11-09
PCT/US2018/019651 WO2018157027A1 (en) 2017-02-27 2018-02-26 Humanized model of kidney and liver disorders

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JP2020510827A JP2020510827A (ja) 2020-04-09
JP2020510827A5 JP2020510827A5 (enExample) 2021-04-01
JP7169979B2 true JP7169979B2 (ja) 2022-11-11

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BR112020003609A2 (pt) 2017-09-29 2020-09-01 Regeneron Pharmaceuticals, Inc. sistema e método para formar uma emulsão
WO2020018511A1 (en) 2018-07-16 2020-01-23 Regeneron Pharmaceuticals, Inc. Non-human animal models of ditra disease and uses thereof
US20220053741A1 (en) * 2018-09-13 2022-02-24 Regeneron Pharmaceuticals, Inc. Complement Factor H Gene Knockout Rat as a Model of C3 Glomerulopathy
AU2020253532B2 (en) 2019-04-04 2024-06-20 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized coagulation factor 12 locus
CN113874510A (zh) 2019-06-04 2021-12-31 瑞泽恩制药公司 包括具有β滑移突变的人源化TTR基因座的非人动物和使用方法
US11622547B2 (en) 2019-06-07 2023-04-11 Regeneran Pharmaceuticals, Inc. Genetically modified mouse that expresses human albumin
WO2021112235A1 (ja) * 2019-12-05 2021-06-10 国立大学法人宮崎大学 Ｃ３腎症を予防又は治療するための医薬、医薬組成物及び補体Ｃ３ｂ分解促進剤
WO2022072671A1 (en) * 2020-10-01 2022-04-07 Regeneron Pharmaceuticals, Inc. Rodent animals expressing human cr1
WO2025122669A1 (en) 2023-12-05 2025-06-12 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized complement factor b gene

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