JP7166915B2 - 体液から物質を濾過する為の接線流フィルターシステム - Google Patents
体液から物質を濾過する為の接線流フィルターシステム Download PDFInfo
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/58—Multistep processes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/88—Draining devices having means for processing the drained fluid, e.g. an absorber
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/88—Draining devices having means for processing the drained fluid, e.g. an absorber
- A61M1/884—Draining devices provided with means for filtering out the harmless water content before discarding the drainage container
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/147—Microfiltration
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/149—Multistep processes comprising different kinds of membrane processes selected from ultrafiltration or microfiltration
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/22—Controlling or regulating
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/32—Controlling or regulating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0464—Cerebrospinal fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3327—Measuring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/11—Laminar flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/005—Parameter used as control input for the apparatus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
- A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
- A61M27/006—Cerebrospinal drainage; Accessories therefor, e.g. valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/06—Specific process operations in the permeate stream
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/12—Addition of chemical agents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/16—Flow or flux control
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/12—Specific discharge elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/18—Specific valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/08—Fully permeating type; Dead-end filtration
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/10—Cross-flow filtration
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2317/00—Membrane module arrangements within a plant or an apparatus
- B01D2317/02—Elements in series
- B01D2317/022—Reject series
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2317/00—Membrane module arrangements within a plant or an apparatus
- B01D2317/04—Elements in parallel
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2317/00—Membrane module arrangements within a plant or an apparatus
- B01D2317/08—Use of membrane modules of different kinds
Description
Claims (10)
- ヒトまたは動物被験者の脳脊髄液(CSF)から物質を濾過する為の濾過システムは、
第1流速で被験者のCSFを含む腔所からCSFからなる液体を抜き取り、且つ、動作パラメーターセットに従って動作するように構成され、
前記濾過システムは、前記液体を透過液と残留液とに濾過する為の接線流フィルターと、濾過中に前記液体の特性を測定する為の検出器とを備え、前記特性は、残留液量に対する透過液量の比率からなり、前記透過液量は、前記フィルターの膜を通過する液体の体積であり、前記残留液量は、前記フィルターの膜を通過しない液体の体積であり、前記残留液量に対する透過液量の比率は濾過中に断続的又は連続的に監視され、
前記濾過システムは、前記透過液を第2流速で前記被験者のCSFを含む腔所に戻すように構成され、
前記濾過システムは、測定した前記特性が濾過中に予め定めた閾値を超えたとの判断に応答して、測定した前記特性に基づいて前記動作パラメーターセットのパラメーターを更新するように構成され、
前記パラメーターの更新は、前記第1流速と前記第2流速とを上昇させる、濾過システム。 - 前記濾過システムは、前記被験者のCSFを含む腔所の内部に挿入された複数の管腔を有するカテーテルを介して前記被験者のCSFを含む腔所と流体接続状態にある、請求項1に記載の濾過システム。
- 前記パラメーターは、前記第1流速と前記第2流速とからなる、請求項1に記載の濾過システム。
- 前記動作パラメーターセットのパラメーターの更新は、前記第1流速と前記第2流速とを同一にする、請求項3に記載の濾過システム。
- 前記液体の第2特性を測定する為の第2の検出器をさらに備え、前記第2特性は、1時間当たりの抜き取った液体の総量から1時間当たりの戻した液体の総量を引いた値である、請求項1に記載の濾過システム。
- 前記濾過システムは、前記第2特性が、第2閾値を超えたか否かを判断するように構成され、前記第2閾値は、脊髄性頭痛を誘導することが予測される、前記1時間当たりの抜き取った液体の総量から1時間当たりの戻した液体の総量を引いた値である、請求項5に記載の濾過システム。
- 前記濾過システムは、前記第2特性が前記第2閾値を超えたとの判断に応答して第2パラメーターを更新し、前記第2パラメーターは、流速パラメーターからなり、前記第2パラメーターの更新は、前記第1流速と前記第2流速とを低下させる、請求項6に記載の濾過システム。
- 前記被験者は、ヒト被験者であり、かつ脊髄性頭痛を誘導することが予測される、前記1時間当たりの抜き取った液体の総量から1時間当たりの戻した液体の総量を引いた値は、1時間当たり35ミリリットルと1時間当たり45ミリリットルの間である、請求項6に記載の濾過システム。
- 前記液体を前記CSFを含む腔所から抜き取る速度は、毎分0.04ミリリットルから毎分30ミリリットルの間である、請求項1に記載の濾過システム。
- 残留液の絶対流速である前記液体の第2特性を測定する為の第2の検出器をさらに備え、
前記濾過システムは、前記第2特性が、残留液の許容可能な流速の範囲である第2閾値を超えたか否かを判断するように構成され、且つ、
前記濾過システムは、前記残留液の絶対流速を前記残留液の許容可能な流速の範囲に戻すために前記動作パラメーターセットの第2パラメーターを更新するように構成されている、請求項1に記載の濾過システム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201562201287P | 2015-08-05 | 2015-08-05 | |
US62/201,287 | 2015-08-05 | ||
PCT/US2016/036626 WO2017023419A1 (en) | 2015-08-05 | 2016-06-09 | Tangential flow filter system for the filtration of materials from biologic fluids |
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JP2020061483A Division JP6995916B2 (ja) | 2015-08-05 | 2020-03-30 | 体液から物質を濾過する為の接線流フィルターシステム |
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JP2018523524A JP2018523524A (ja) | 2018-08-23 |
JP2018523524A5 JP2018523524A5 (ja) | 2021-10-07 |
JP7166915B2 true JP7166915B2 (ja) | 2022-11-08 |
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JP2020061483A Active JP6995916B2 (ja) | 2015-08-05 | 2020-03-30 | 体液から物質を濾過する為の接線流フィルターシステム |
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US (2) | US20210077951A1 (ja) |
EP (2) | EP3714915B1 (ja) |
JP (2) | JP7166915B2 (ja) |
CN (1) | CN108367102B (ja) |
AU (3) | AU2016304020B2 (ja) |
CA (1) | CA2994669C (ja) |
ES (2) | ES2797223T3 (ja) |
WO (1) | WO2017023419A1 (ja) |
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US20190105475A1 (en) | 2017-10-05 | 2019-04-11 | Minnetronix, Inc. | Systems, catheters, and methods for treating along the central nervous system |
EP3817801A1 (en) * | 2018-07-02 | 2021-05-12 | Minnetronix Neuro, Inc. | Systems, catheters, and methods for treating along the central nervous system |
AU2021271803A1 (en) * | 2020-05-11 | 2022-12-08 | Minnetronix Neuro, Inc. | Filtering cassettes and filtering systems |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4904237A (en) | 1988-05-16 | 1990-02-27 | Janese Woodrow W | Apparatus for the exchange of cerebrospinal fluid and a method of treating brain and spinal cord injuries |
US20070246406A1 (en) | 2006-03-31 | 2007-10-25 | Dibel Kevin R | Tangential flow filtration apparatuses, systems, and processes for the separation of compounds |
JP2010505556A (ja) | 2006-10-09 | 2010-02-25 | ニューロフルーディクス, インコーポレイテッド | 脳脊髄液精製システム |
WO2010123558A1 (en) | 2009-04-22 | 2010-10-28 | Neurofluidics, Inc. | Programmable system for conditioning of cerebrospinal fluid |
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US20230120296A1 (en) | 2023-04-20 |
ES2906952T3 (es) | 2022-04-21 |
ES2797223T3 (es) | 2020-12-01 |
EP3331586A1 (en) | 2018-06-13 |
WO2017023419A1 (en) | 2017-02-09 |
EP3714915A1 (en) | 2020-09-30 |
US20210077951A1 (en) | 2021-03-18 |
AU2016304020B2 (en) | 2019-09-19 |
CA2994669A1 (en) | 2017-02-09 |
CA2994669C (en) | 2020-11-17 |
AU2019283901A1 (en) | 2020-01-23 |
AU2016304020A1 (en) | 2018-02-22 |
CN108367102A (zh) | 2018-08-03 |
AU2021218067A1 (en) | 2021-09-09 |
AU2019283901B2 (en) | 2021-05-20 |
EP3714915B1 (en) | 2021-11-03 |
CN108367102B (zh) | 2021-04-30 |
JP6995916B2 (ja) | 2022-01-17 |
EP3331586A4 (en) | 2019-04-03 |
JP2020124526A (ja) | 2020-08-20 |
JP2018523524A (ja) | 2018-08-23 |
EP3331586B1 (en) | 2020-04-29 |
AU2021218067B2 (en) | 2023-03-16 |
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