JP7158286B2 - ＰＩ３Ｋβ阻害剤としてのアザベンゾイミダゾール誘導体 - Google Patents

ＰＩ３Ｋβ阻害剤としてのアザベンゾイミダゾール誘導体 Download PDF

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JP7158286B2
JP7158286B2 JP2018565868A JP2018565868A JP7158286B2 JP 7158286 B2 JP7158286 B2 JP 7158286B2 JP 2018565868 A JP2018565868 A JP 2018565868A JP 2018565868 A JP2018565868 A JP 2018565868A JP 7158286 B2 JP7158286 B2 JP 7158286B2
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JP2019518059A (ja
JP2019518059A5 (enExample
Inventor
ピラット，イザベル，ノエル，コンスタンス
ケロル，オリヴィエ，アレシス，ジョルジュ
アンギボ，パトリック，ルネ
ベルスロ，ディディエ，ジャン－クロード
クパ，ソフィー
デメストル，クリストフ，ガブリエル，マルセル
ミーアペール，リーヴェン
メルシー，ギヨーム，ジャン，モーリス
ミヴェレック，ローレンス，アン
メイヤー，クリストフ
パスキア，エリザベス，テレーズ，ジャンヌ
ポンセレ，ヴィルジニィ，ソフィー
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ヤンセン ファーマシューティカ エヌ．ベー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2018565868A 2016-06-16 2017-06-15 ＰＩ３Ｋβ阻害剤としてのアザベンゾイミダゾール誘導体 Active JP7158286B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16174712 2016-06-16
EP16174712.6 2016-06-16
PCT/EP2017/064672 WO2017216293A1 (en) 2016-06-16 2017-06-15 Azabenzimidazole derivatives as pi3k beta inhibitors

Publications (3)

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JP2019518059A JP2019518059A (ja) 2019-06-27
JP2019518059A5 JP2019518059A5 (enExample) 2020-07-27
JP7158286B2 true JP7158286B2 (ja) 2022-10-21

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JP2018565868A Active JP7158286B2 (ja) 2016-06-16 2017-06-15 ＰＩ３Ｋβ阻害剤としてのアザベンゾイミダゾール誘導体

Country Status (13)

Country Link
US (1) US20190263804A1 (enExample)
EP (1) EP3472147B1 (enExample)
JP (1) JP7158286B2 (enExample)
KR (1) KR102472198B1 (enExample)
CN (1) CN109311843B (enExample)
AU (1) AU2017286380B2 (enExample)
BR (1) BR112018076169A2 (enExample)
CA (1) CA3025746A1 (enExample)
EA (1) EA037871B1 (enExample)
ES (1) ES2818620T3 (enExample)
IL (1) IL263653A (enExample)
MX (1) MX375484B (enExample)
WO (1) WO2017216293A1 (enExample)

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EP3904350B1 (en) 2018-04-12 2023-08-23 Bayer Aktiengesellschaft N-(cyclopropylmethyl)-5-(methylsulfonyl)-n-{1-[1-(pyrimidin-2-yl)-1h-1,2,4-triazol-5-yl]ethyl}benzamide derivatives and the corresponding pyridine-carboxamide derivatives as pesticides
WO2019209811A1 (en) 2018-04-24 2019-10-31 Bristol-Myers Squibb Company Macrocyclic toll-like receptor 7 (tlr7) agonists
UA127065C2 (uk) 2018-04-25 2023-03-29 Баєр Акціенгезельшафт Нові гетероарил-триазольні та гетероарил-тетразольні сполуки як пестициди
US11554120B2 (en) 2018-08-03 2023-01-17 Bristol-Myers Squibb Company 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor
MX2022000954A (es) 2019-07-23 2022-02-14 Bayer Ag Novedosos compuestos de heteroaril-triazol como plaguicidas.
CN110551101B (zh) * 2019-08-28 2020-11-24 沈阳药科大学 1、6-二取代-苯并五元杂环类衍生物及其用途
TW202128664A (zh) 2019-10-09 2021-08-01 德商拜耳廠股份有限公司 作為除害劑之新穎雜芳基三唑化合物
EP4097102A1 (en) 2020-01-27 2022-12-07 Bristol-Myers Squibb Company 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists
US20230140430A1 (en) 2020-01-27 2023-05-04 Bristol-Myers Squibb Company 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS
JP2023512230A (ja) 2020-01-27 2023-03-24 ブリストル－マイヤーズ スクイブ カンパニー トール様受容体７（ＴＬＲ７）アゴニストとしてのＣ３置換１Ｈ－ピラゾロ［４，３－ｄ］ピリミジン化合物
KR20220132602A (ko) 2020-01-27 2022-09-30 브리스톨-마이어스 스큅 컴퍼니 톨-유사 수용체 7 (TLR7) 효능제로서의 1H-피라졸로[4,3-d]피리미딘 화합물
US12485123B2 (en) 2020-01-27 2025-12-02 Bristol-Myers Squibb Company 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists
KR20220132592A (ko) 2020-01-27 2022-09-30 브리스톨-마이어스 스큅 컴퍼니 톨-유사 수용체 7 (TLR7) 효능제로서의 1H-피라졸로[4,3-d]피리미딘 화합물
CN115210235A (zh) 2020-01-27 2022-10-18 百时美施贵宝公司 作为Toll样受体7(TLR7)激动剂的1H-吡唑并[4,3-d]嘧啶化合物
KR20220132601A (ko) 2020-01-27 2022-09-30 브리스톨-마이어스 스큅 컴퍼니 톨-유사 수용체 7 (TLR7) 효능제로서의 1H-피라졸로[4,3-d]피리미딘 화합물
CN115151548A (zh) 2020-01-27 2022-10-04 百时美施贵宝公司 作为Toll样受体7(TLR7)激动剂的1H-吡唑并[4,3-d]嘧啶化合物
MX2024010099A (es) * 2022-02-18 2024-08-28 Xizang Haisco Pharmaceutical Co Ltd Derivado de pirazolopiridina y aplicacion del mismo en medicina.
CN121001723A (zh) * 2023-04-27 2025-11-21 海思科医药集团股份有限公司 一种吡啶并吡唑衍生物的药物组合物及其在医药上的应用

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WO2013095761A1 (en) 2011-12-20 2013-06-27 Glaxosmithkline Llc Imidazopyridine derivatives as pi3 kinase inhibitors
JP2013539753A (ja) 2010-10-06 2013-10-28 グラクソスミスクライン エルエルシー Ｐｉ３キナーゼ阻害剤としてのベンズイミダゾール誘導体

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JP2019518059A (ja) 2019-06-27
US20190263804A1 (en) 2019-08-29
ES2818620T3 (es) 2021-04-13
MX2018015709A (es) 2019-03-21
CA3025746A1 (en) 2017-12-21
EP3472147B1 (en) 2020-06-17
KR20190016976A (ko) 2019-02-19
BR112018076169A2 (pt) 2019-03-26
AU2017286380B2 (en) 2021-02-04
AU2017286380A1 (en) 2018-12-06
EA037871B1 (ru) 2021-05-28
EA201892734A1 (ru) 2019-05-31
CN109311843B (zh) 2021-10-08
MX375484B (es) 2025-03-06
EP3472147A1 (en) 2019-04-24
KR102472198B1 (ko) 2022-11-28
IL263653A (en) 2019-01-31
WO2017216293A1 (en) 2017-12-21
CN109311843A (zh) 2019-02-05

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