JP7148987B2 - 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法 - Google Patents

眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法 Download PDF

Info

Publication number
JP7148987B2
JP7148987B2 JP2019518175A JP2019518175A JP7148987B2 JP 7148987 B2 JP7148987 B2 JP 7148987B2 JP 2019518175 A JP2019518175 A JP 2019518175A JP 2019518175 A JP2019518175 A JP 2019518175A JP 7148987 B2 JP7148987 B2 JP 7148987B2
Authority
JP
Japan
Prior art keywords
serum
chitosan
composition
plasma
weight percent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019518175A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019525951A (ja
JP2019525951A5 (OSRAM
Inventor
ダウリング，マシュー・ビー
レイザー，スティーブン・イー
ジェンティル，ヘルガ・エム
Original Assignee
アイ・ケア・インターナショナル，エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アイ・ケア・インターナショナル，エルエルシー filed Critical アイ・ケア・インターナショナル，エルエルシー
Publication of JP2019525951A publication Critical patent/JP2019525951A/ja
Publication of JP2019525951A5 publication Critical patent/JP2019525951A5/ja
Priority to JP2022145970A priority Critical patent/JP7473237B2/ja
Application granted granted Critical
Publication of JP7148987B2 publication Critical patent/JP7148987B2/ja
Priority to JP2024060611A priority patent/JP2024096781A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4869—Determining body composition
    • A61B5/4875—Hydration status, fluid retention of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
JP2019518175A 2016-06-16 2017-06-16 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法 Active JP7148987B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022145970A JP7473237B2 (ja) 2016-06-16 2022-09-14 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法
JP2024060611A JP2024096781A (ja) 2016-06-16 2024-04-04 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662350772P 2016-06-16 2016-06-16
US62/350,772 2016-06-16
PCT/US2017/037954 WO2017218942A1 (en) 2016-06-16 2017-06-16 Compositions and methods of treating dry syndrome and other traumatized non-keratinized epithelial surfaces

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022145970A Division JP7473237B2 (ja) 2016-06-16 2022-09-14 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法

Publications (3)

Publication Number Publication Date
JP2019525951A JP2019525951A (ja) 2019-09-12
JP2019525951A5 JP2019525951A5 (OSRAM) 2020-07-30
JP7148987B2 true JP7148987B2 (ja) 2022-10-06

Family

ID=60663416

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019518175A Active JP7148987B2 (ja) 2016-06-16 2017-06-16 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法
JP2022145970A Active JP7473237B2 (ja) 2016-06-16 2022-09-14 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法
JP2024060611A Pending JP2024096781A (ja) 2016-06-16 2024-04-04 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022145970A Active JP7473237B2 (ja) 2016-06-16 2022-09-14 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法
JP2024060611A Pending JP2024096781A (ja) 2016-06-16 2024-04-04 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法

Country Status (6)

Country Link
US (3) US11191781B2 (OSRAM)
EP (1) EP3471742A4 (OSRAM)
JP (3) JP7148987B2 (OSRAM)
CN (1) CN109862899A (OSRAM)
CA (1) CA3027969A1 (OSRAM)
WO (1) WO2017218942A1 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109862899A (zh) 2016-06-16 2019-06-07 护眼国际有限责任公司 治疗干眼综合征及其他创伤性非角质化上皮表面的组合物和方法
WO2019231133A1 (ko) * 2018-05-31 2019-12-05 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물
WO2020113075A1 (en) * 2018-11-29 2020-06-04 Cellula Llc The composition of umbilical cord blood serum
EP3968965A1 (en) * 2019-05-13 2022-03-23 Bone Therapeutics S.A. Improved lyophilized formulations involving hyaluronic acid and plasmatic proteins, and uses thereof
IT201900010740A1 (it) * 2019-07-02 2021-01-02 Medacta Int Sa Biocompatible compositions comprising a biocompatible thickening polymer and a chitosan derivative
WO2024003424A1 (es) * 2022-06-28 2024-01-04 Compliance Consulting And Engineering Services, S.L. Sistema para el control del proceso de liofilización en un liofilizador con sistema de castillo de placas y método para la generación de un espacio de diseño
US20240226181A1 (en) * 2023-01-11 2024-07-11 Biostem Technologies, Inc. Human umbilical cord composition for treatment of peyronie's disease
CN117017945B (zh) * 2023-08-14 2026-02-06 珠海横琴澳叶健康科技有限公司 一种离子响应型蒙花苷纳米粒子及其制备方法和应用
WO2025165681A1 (en) * 2024-01-31 2025-08-07 Serorepair Llc Serum compositions with additive for ocular delivery in animals
CN118662706B (zh) * 2024-06-17 2025-01-10 韶关朗圣药业有限公司 一种人体润滑液及其制备方法和应用
EP4740931A1 (en) * 2024-11-06 2026-05-13 Oral Care Solutions GmbH Oral care composition for use in the treatment of dry mouth

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000030609A1 (en) 1998-11-20 2000-06-02 Laboratoire Medidom S.A. Aqueous ophthalmic formulations comprising chitosan
JP2010522176A (ja) 2007-03-19 2010-07-01 ヘムコン メディカル テクノロジーズ， インコーポレイテッド 凍結乾燥された血漿などの凍結乾燥材料を製造、貯蔵、および投与するための装置および方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713980D0 (en) 1997-07-03 1997-09-10 Danbiosyst Uk New conjugates
WO2003094937A1 (en) 2002-05-09 2003-11-20 Medigenes A pharmaceutical composition for treatment of wounds containing blood plasma or serum
US20080299212A1 (en) * 2005-02-25 2008-12-04 Medigenes Co., Ltd Pharmaceutical Composition for Treating Avellino Cornea Dystrophy Comprising Blood Plasma or Serum
US20090035289A1 (en) * 2005-09-26 2009-02-05 Lifecell Corporation Dry platelet composition
WO2007059084A2 (en) * 2005-11-14 2007-05-24 The New England Medical Center Hospitals, Inc. Methods for preparing cord matrix stem cells (cmsc) for long term storage and for preparing a segment of umbilical cord for cryopreservation
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
US20090223080A1 (en) * 2007-03-19 2009-09-10 Hemcon Medical Technologies, Inc. Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma
WO2010085792A1 (en) * 2009-01-26 2010-07-29 Oregon Biomedical Engineering Institute Dehydrated plasma kit
CN101829048B (zh) * 2010-01-21 2012-04-18 厦门大学 一种滴眼液及其制备方法
ES2368394B1 (es) * 2011-07-13 2012-06-08 Banc De Sang I Teixits Composición que comprende plasma de sangre de cordon umbilical para el tratamiento de patologías de la superficie ocular y procedimiento de obtención de la misma.
WO2014028745A2 (en) 2012-08-17 2014-02-20 Archon Pharmaceutical Consulting Llc A system for compounding and packaging ready to reconstitute drug powders of solutions to a solution or to a suspension or to an injectable
CA2914610C (en) 2013-03-13 2022-08-02 University Of Maryland Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
EP3052083A4 (en) 2013-09-30 2017-05-03 Bioactive Regenerative Therapeutics, Inc. Biomimetic hybrid gel compositions and methods of use
AU2015221389B2 (en) 2014-02-20 2018-12-13 Ortho Regenerative Technologies Inc. Freeze-dried polymer compositions for mixing with platelet rich plasma to form implants for tissue repair and/or compositions for therapeutic intra-articular injections
EP3119392A4 (en) * 2014-03-17 2017-10-11 Encompass Development Inc. Ocular formulations
CA2963435A1 (en) * 2014-10-06 2016-04-14 Fondazione Irccs Ca' Granda - Ospedale Maggiore Policlinico Umbilical cord blood plasma for treatment of corneal pathology
DE102015205293A1 (de) * 2015-03-24 2016-09-29 Marc Schrott Verfahren zur Herstellung von Augentropfen
CN109862899A (zh) 2016-06-16 2019-06-07 护眼国际有限责任公司 治疗干眼综合征及其他创伤性非角质化上皮表面的组合物和方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000030609A1 (en) 1998-11-20 2000-06-02 Laboratoire Medidom S.A. Aqueous ophthalmic formulations comprising chitosan
JP2010522176A (ja) 2007-03-19 2010-07-01 ヘムコン メディカル テクノロジーズ， インコーポレイテッド 凍結乾燥された血漿などの凍結乾燥材料を製造、貯蔵、および投与するための装置および方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Am. J. Ophthalmol., (2007), 144, [1], p.86-92

Also Published As

Publication number Publication date
WO2017218942A1 (en) 2017-12-21
JP7473237B2 (ja) 2024-04-23
WO2017218942A8 (en) 2019-01-24
EP3471742A1 (en) 2019-04-24
CA3027969A1 (en) 2017-12-21
US11191781B2 (en) 2021-12-07
JP2019525951A (ja) 2019-09-12
US11534459B2 (en) 2022-12-27
US20230321145A1 (en) 2023-10-12
US20220168341A1 (en) 2022-06-02
CN109862899A (zh) 2019-06-07
EP3471742A4 (en) 2020-03-04
JP2024096781A (ja) 2024-07-17
US20190175647A1 (en) 2019-06-13
JP2022191232A (ja) 2022-12-27

Similar Documents

Publication Publication Date Title
JP7473237B2 (ja) 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法
Nguyen et al. Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment
KR100307685B1 (ko) 눈의전방챔버에서축동제및산동제의조절방출법
US11633432B2 (en) Amniotic fluid topical formulation
Li et al. Gelatin scaffold with multifunctional curcumin-loaded lipid-PLGA hybrid microparticles for regenerating corneal endothelium
JPH0121133B2 (OSRAM)
Das et al. The gamut of perspectives, challenges, and recent trends for in situ hydrogels: A smart ophthalmic drug delivery vehicle
BRPI0708622A2 (pt) terapia ocular usando agentes que ativam a sirtuina
JP2017514916A (ja) 水性点眼液およびドライアイ症候群の治療方法
Calles et al. Polymers in ophthalmology
Mundada et al. In situ gelling polymers in ocular drug delivery systems: a review
CN107847604A (zh) 眼用原位凝胶处方
Wang et al. Applications and recent developments of hydrogels in ophthalmology
Yan et al. Advances in adhesive hydrogels applied for ophthalmology: An overview focused on the treatment
CN101810563B (zh) 他克莫司眼用在体凝胶制剂及其制备方法
CN104814924A (zh) 一种布佐林胺脂质体眼用制剂及其制备方法
JPH10265378A (ja) 角膜上皮損傷治療剤
KR101341647B1 (ko) 베타-글루칸을 포함하는 각결막염 치료용 점안제 조성물
CN118902984A (zh) 序贯控释双药物负载可注射水凝胶及其制备方法和应用
CN104721130B (zh) 一种布林佐胺包合物眼用制剂及其制备方法
CN104721145A (zh) 一种布佐林胺纳米粒眼用制剂及其制备方法
HK40009946A (en) Compositions and methods of treating dry eye syndrome and other traumatized non-keratinized epithelial surfaces
JP2018535962A (ja) 滅菌水性点眼液の治療的使用
RU2232582C2 (ru) Глазная пленка
US20210220515A1 (en) Viscoelastic agent material

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200616

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200616

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210625

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210915

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20210915

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220126

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220425

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220817

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220915

R150 Certificate of patent or registration of utility model

Ref document number: 7148987

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250