JP7143286B2 - 精製ヒトミルクオリゴ糖組成物 - Google Patents

精製ヒトミルクオリゴ糖組成物 Download PDF

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JP7143286B2
JP7143286B2 JP2019515302A JP2019515302A JP7143286B2 JP 7143286 B2 JP7143286 B2 JP 7143286B2 JP 2019515302 A JP2019515302 A JP 2019515302A JP 2019515302 A JP2019515302 A JP 2019515302A JP 7143286 B2 JP7143286 B2 JP 7143286B2
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hmo
permeate
lactase
human milk
purified
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JP2019528740A5 (enExample
JP2019528740A (ja
Inventor
サン，アダム
ブーデック，アナベル ル
ディー． フィン，ティン
トゥ トラン，キム
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プロラクタ バイオサイエンス，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/1203—Addition of, or treatment with, enzymes or microorganisms other than lactobacteriaceae
    • A23C9/1206—Lactose hydrolysing enzymes, e.g. lactase, beta-galactosidase
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
    • A23C9/1422—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration by ultrafiltration, microfiltration or diafiltration of milk, e.g. for separating protein and lactose; Treatment of the UF permeate
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • A23C9/206—Colostrum; Human milk
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01108—Lactase (3.2.1.108)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/324—Foods, ingredients or supplements having a functional effect on health having an effect on the immune system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/28—Oligosaccharides
    • A23V2250/282—Oligosaccharides, digestible
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Water Supply & Treatment (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dairy Products (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
JP2019515302A 2016-09-19 2017-09-19 精製ヒトミルクオリゴ糖組成物 Active JP7143286B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022146600A JP7510978B2 (ja) 2016-09-19 2022-09-14 精製ヒトミルクオリゴ糖組成物
JP2024101036A JP2024150451A (ja) 2016-09-19 2024-06-24 精製ヒトミルクオリゴ糖組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662396779P 2016-09-19 2016-09-19
US62/396,779 2016-09-19
PCT/US2017/052332 WO2018053535A1 (en) 2016-09-19 2017-09-19 Purified human milk oligosaccharides compositions

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JP2022146600A Division JP7510978B2 (ja) 2016-09-19 2022-09-14 精製ヒトミルクオリゴ糖組成物

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JP2019528740A JP2019528740A (ja) 2019-10-17
JP2019528740A5 JP2019528740A5 (enExample) 2020-11-12
JP7143286B2 true JP7143286B2 (ja) 2022-09-28

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JP2022146600A Active JP7510978B2 (ja) 2016-09-19 2022-09-14 精製ヒトミルクオリゴ糖組成物
JP2024101036A Pending JP2024150451A (ja) 2016-09-19 2024-06-24 精製ヒトミルクオリゴ糖組成物

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JP2024101036A Pending JP2024150451A (ja) 2016-09-19 2024-06-24 精製ヒトミルクオリゴ糖組成物

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US (2) US20200054035A1 (enExample)
EP (1) EP3515195A4 (enExample)
JP (3) JP7143286B2 (enExample)
KR (2) KR102593408B1 (enExample)
CN (1) CN109843073A (enExample)
AU (3) AU2017326654C1 (enExample)
BR (1) BR112019005329A2 (enExample)
CA (1) CA3037203A1 (enExample)
IL (2) IL290057B2 (enExample)
MX (1) MX2019002924A (enExample)
RU (1) RU2754463C2 (enExample)
WO (1) WO2018053535A1 (enExample)

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MX2022002949A (es) 2019-09-24 2022-04-06 Prolacta Bioscience Inc Composiciones y metodos para el tratamiento de enfermedades inflamatorias e inmunes.
KR20220072866A (ko) * 2019-10-01 2022-06-02 글리콤 에이/에스 발효액으로부터 중성 올리고사카라이드의 분리
WO2022148549A1 (en) 2020-01-14 2022-07-14 Babylat Gmbh Apparatus and method for obtaining protein-enriched fractions from breast milk
WO2021250191A1 (en) * 2020-06-12 2021-12-16 Basf Se Improved demineralization of fermentation broths and purification of fine chemicals such as oligosaccharides
IL300573A (en) * 2020-08-14 2023-04-01 Prolacta Bioscience Inc Breast milk oligosaccharide compositions for use with bacteriotherapy
JP2024502629A (ja) 2021-01-12 2024-01-22 プロラクタ バイオサイエンス，インコーポレイテッド シンバイオティック治療レジメン
WO2022159705A1 (en) 2021-01-22 2022-07-28 Prolacta Bioscience, Inc. Topical human milk formulations
EP4042875B1 (en) * 2021-02-15 2025-07-30 Rakesh Kumar Aggarwal A human milk fortifier
CN113899827A (zh) * 2021-09-29 2022-01-07 中国科学院合肥物质科学研究院 一种3’-唾液酸乳糖的检测方法及其应用
WO2023122270A2 (en) * 2021-12-23 2023-06-29 Amyris, Inc. Compositions and methods for improved production of human milk oligosaccharides
AU2022331912B2 (en) * 2021-12-29 2024-05-02 Beijing Sanyuan Foods Co., Ltd. Preparation method of milk oligosaccharides and oligosaccharide powder and food prepared thereby
WO2024130119A2 (en) 2022-12-16 2024-06-20 Prolacta Bioscience, Inc. Synbiotic compositions for short chain fatty acid production

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JP2003522539A (ja) 2000-02-16 2003-07-29 ネオス テクノロジーズ インコーポレイテッド 酪農水流の濾過方法
US20070192878A1 (en) 2006-02-16 2007-08-16 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
US20120040051A1 (en) 2010-08-13 2012-02-16 Kwan-Han Chen Process for preparing milk product enhanced with galactooligosaccharide and easily absorbable, and functional milk product prepared therewith
JP2012510476A (ja) 2008-12-02 2012-05-10 プロラクタ バイオサイエンス，インコーポレイテッド ヒト乳透過組成物ならびにその製造および使用方法
JP2012520325A (ja) 2009-03-13 2012-09-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア プレバイオティックオリゴ糖
WO2012124668A1 (ja) 2011-03-14 2012-09-20 合同酒精株式会社 アリールスルファターゼの活性測定方法
US20140087021A1 (en) 2011-05-24 2014-03-27 Nestec S.A Milk oligosaccharide-galactooligosaccharide composition for infant formula containing the soluble oligosaccharide fraction present in milk, and having a low level of monosaccharides, and a process to produce the composition
WO2016088589A1 (ja) 2014-12-05 2016-06-09 合同酒精株式会社 ラクターゼ溶液及びそれを用いた乳製品

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US20070192878A1 (en) 2006-02-16 2007-08-16 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
JP2012510476A (ja) 2008-12-02 2012-05-10 プロラクタ バイオサイエンス，インコーポレイテッド ヒト乳透過組成物ならびにその製造および使用方法
JP2012520325A (ja) 2009-03-13 2012-09-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア プレバイオティックオリゴ糖
US20120040051A1 (en) 2010-08-13 2012-02-16 Kwan-Han Chen Process for preparing milk product enhanced with galactooligosaccharide and easily absorbable, and functional milk product prepared therewith
WO2012124668A1 (ja) 2011-03-14 2012-09-20 合同酒精株式会社 アリールスルファターゼの活性測定方法
US20140087021A1 (en) 2011-05-24 2014-03-27 Nestec S.A Milk oligosaccharide-galactooligosaccharide composition for infant formula containing the soluble oligosaccharide fraction present in milk, and having a low level of monosaccharides, and a process to produce the composition
WO2016088589A1 (ja) 2014-12-05 2016-06-09 合同酒精株式会社 ラクターゼ溶液及びそれを用いた乳製品

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RU2754463C2 (ru) 2021-09-02
IL265373B (en) 2022-02-01
KR102821643B1 (ko) 2025-06-18
JP2024150451A (ja) 2024-10-23
US20200054035A1 (en) 2020-02-20
US20250089732A1 (en) 2025-03-20
RU2019110171A (ru) 2020-10-19
AU2017326654C1 (en) 2022-07-21
AU2024204350A1 (en) 2024-07-11
IL265373A (en) 2019-05-30
MX2019002924A (es) 2019-10-14
IL290057B1 (en) 2023-05-01
BR112019005329A2 (pt) 2019-06-18
EP3515195A1 (en) 2019-07-31
KR20230130667A (ko) 2023-09-12
WO2018053535A1 (en) 2018-03-22
JP7510978B2 (ja) 2024-07-04
KR20190054097A (ko) 2019-05-21
AU2017326654A1 (en) 2019-03-14
JP2023002512A (ja) 2023-01-10
AU2022202598B2 (en) 2024-04-04
CA3037203A1 (en) 2018-03-22
JP2019528740A (ja) 2019-10-17
CN109843073A (zh) 2019-06-04
AU2022202598A1 (en) 2022-05-12
RU2019110171A3 (enExample) 2021-02-11
AU2017326654B2 (en) 2022-01-20
IL290057B2 (en) 2023-09-01
KR102593408B1 (ko) 2023-10-25
EP3515195A4 (en) 2020-05-27
IL290057A (en) 2022-03-01

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