RU2754463C2 - Очищенные композиции олигосахаридов грудного молока - Google Patents

Очищенные композиции олигосахаридов грудного молока Download PDF

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RU2754463C2
RU2754463C2 RU2019110171A RU2019110171A RU2754463C2 RU 2754463 C2 RU2754463 C2 RU 2754463C2 RU 2019110171 A RU2019110171 A RU 2019110171A RU 2019110171 A RU2019110171 A RU 2019110171A RU 2754463 C2 RU2754463 C2 RU 2754463C2
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permeate
lactase
mixture
ogm
purified
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RU2019110171A
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English (en)
Russian (ru)
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RU2019110171A3 (enExample
RU2019110171A (ru
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Адам САН
Аннабель ЛЕ БУДЕК
Тин Д. ХЮИНЬ
Ким Тху ТРАН
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Пролакта Байосайенс, Инк.
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
    • A23C9/1422—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration by ultrafiltration, microfiltration or diafiltration of milk, e.g. for separating protein and lactose; Treatment of the UF permeate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/1203—Addition of, or treatment with, enzymes or microorganisms other than lactobacteriaceae
    • A23C9/1206—Lactose hydrolysing enzymes, e.g. lactase, beta-galactosidase
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • A23C9/206—Colostrum; Human milk
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01108—Lactase (3.2.1.108)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/324—Foods, ingredients or supplements having a functional effect on health having an effect on the immune system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/28—Oligosaccharides
    • A23V2250/282—Oligosaccharides, digestible
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Water Supply & Treatment (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dairy Products (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
RU2019110171A 2016-09-19 2017-09-19 Очищенные композиции олигосахаридов грудного молока RU2754463C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662396779P 2016-09-19 2016-09-19
US62/396,779 2016-09-19
PCT/US2017/052332 WO2018053535A1 (en) 2016-09-19 2017-09-19 Purified human milk oligosaccharides compositions

Publications (3)

Publication Number Publication Date
RU2019110171A RU2019110171A (ru) 2020-10-19
RU2019110171A3 RU2019110171A3 (enExample) 2021-02-11
RU2754463C2 true RU2754463C2 (ru) 2021-09-02

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US (2) US20200054035A1 (enExample)
EP (1) EP3515195A4 (enExample)
JP (3) JP7143286B2 (enExample)
KR (2) KR102593408B1 (enExample)
CN (1) CN109843073A (enExample)
AU (3) AU2017326654C1 (enExample)
BR (1) BR112019005329A2 (enExample)
IL (2) IL290057B2 (enExample)
MX (1) MX2019002924A (enExample)
RU (1) RU2754463C2 (enExample)
WO (1) WO2018053535A1 (enExample)

Families Citing this family (12)

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AU2020354581A1 (en) 2019-09-24 2022-03-03 Prolacta Bioscience, Inc. Compositions and methods for treatment of inflammatory and immune diseases
EP4038079A4 (en) * 2019-10-01 2023-11-01 Glycom A/S SEPARATION OF NEUTRAL OLIGOSACCHARIDES FROM A FERMENTATION BROTH
WO2022148549A1 (en) 2020-01-14 2022-07-14 Babylat Gmbh Apparatus and method for obtaining protein-enriched fractions from breast milk
US20230227487A1 (en) * 2020-06-12 2023-07-20 Basf Se Improved demineralization of fermentation broths and purification of fine chemicals such as oligosaccharides
CA3188645A1 (en) 2020-08-14 2022-02-17 Prolacta Bioscience, Inc. Human milk oligosaccharide compositions for use with bacteriotherapies
MX2023008227A (es) 2021-01-12 2023-07-20 Prolacta Bioscience Inc Regimenes de tratamiento simbiotico.
AU2022211396A1 (en) 2021-01-22 2023-06-29 Prolacta Bioscience, Inc. Topical human milk formulations
EP4042875B1 (en) * 2021-02-15 2025-07-30 Rakesh Kumar Aggarwal A human milk fortifier
CN113899827A (zh) * 2021-09-29 2022-01-07 中国科学院合肥物质科学研究院 一种3’-唾液酸乳糖的检测方法及其应用
WO2023122270A2 (en) * 2021-12-23 2023-06-29 Amyris, Inc. Compositions and methods for improved production of human milk oligosaccharides
CN114539433B (zh) * 2021-12-29 2022-11-01 北京三元食品股份有限公司 一种乳低聚糖的制备方法及制备的低聚糖粉、食品
WO2024130119A2 (en) 2022-12-16 2024-06-20 Prolacta Bioscience, Inc. Synbiotic compositions for short chain fatty acid production

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US4485040A (en) * 1979-06-26 1984-11-27 Institut National De La Recherche Agronomique Process for obtaining an α-lactalbumin enriched product from whey, and uses thereof
US6288222B1 (en) * 2000-02-16 2001-09-11 Neose Technologies, Inc. Method of filtration of a dairy stream
EP0975235B1 (en) * 1997-03-31 2006-05-24 Abbott Laboratories Nutritional formulations containing oligosaccharides
CA2642976A1 (en) * 2006-02-16 2007-09-20 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
RU2388478C2 (ru) * 2003-10-24 2010-05-10 Н.В. Нютрисиа Иммуномодулирующие олигосахариды
RU2430631C2 (ru) * 2006-02-10 2011-10-10 Нестек С.А. Пребиотическая смесь олигосахаридов и пищевой продукт, ее содержащий
US20120040051A1 (en) * 2010-08-13 2012-02-16 Kwan-Han Chen Process for preparing milk product enhanced with galactooligosaccharide and easily absorbable, and functional milk product prepared therewith

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EP2405918B2 (en) 2009-03-13 2020-09-02 The Regents of The University of California Prebiotic oligosaccharides
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PL2797436T3 (pl) * 2012-01-01 2021-03-08 Botanical Water Technologies Ip Ltd Sposoby wytwarzania napojów na bazie roślin
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US4485040A (en) * 1979-06-26 1984-11-27 Institut National De La Recherche Agronomique Process for obtaining an α-lactalbumin enriched product from whey, and uses thereof
EP0975235B1 (en) * 1997-03-31 2006-05-24 Abbott Laboratories Nutritional formulations containing oligosaccharides
US6288222B1 (en) * 2000-02-16 2001-09-11 Neose Technologies, Inc. Method of filtration of a dairy stream
RU2388478C2 (ru) * 2003-10-24 2010-05-10 Н.В. Нютрисиа Иммуномодулирующие олигосахариды
RU2430631C2 (ru) * 2006-02-10 2011-10-10 Нестек С.А. Пребиотическая смесь олигосахаридов и пищевой продукт, ее содержащий
CA2642976A1 (en) * 2006-02-16 2007-09-20 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
US20120040051A1 (en) * 2010-08-13 2012-02-16 Kwan-Han Chen Process for preparing milk product enhanced with galactooligosaccharide and easily absorbable, and functional milk product prepared therewith

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BR112019005329A2 (pt) 2019-06-18
AU2022202598B2 (en) 2024-04-04
KR102593408B1 (ko) 2023-10-25
AU2022202598A1 (en) 2022-05-12
IL265373B (en) 2022-02-01
IL265373A (en) 2019-05-30
RU2019110171A3 (enExample) 2021-02-11
RU2019110171A (ru) 2020-10-19
JP7143286B2 (ja) 2022-09-28
US20250089732A1 (en) 2025-03-20
AU2017326654A1 (en) 2019-03-14
JP7510978B2 (ja) 2024-07-04
JP2024150451A (ja) 2024-10-23
KR20190054097A (ko) 2019-05-21
MX2019002924A (es) 2019-10-14
AU2017326654C1 (en) 2022-07-21
US20200054035A1 (en) 2020-02-20
IL290057B2 (en) 2023-09-01
EP3515195A1 (en) 2019-07-31
CN109843073A (zh) 2019-06-04
IL290057A (en) 2022-03-01
KR20230130667A (ko) 2023-09-12
WO2018053535A1 (en) 2018-03-22
IL290057B1 (en) 2023-05-01
AU2017326654B2 (en) 2022-01-20
CA3037203A1 (en) 2018-03-22
JP2023002512A (ja) 2023-01-10
KR102821643B1 (ko) 2025-06-18
EP3515195A4 (en) 2020-05-27
JP2019528740A (ja) 2019-10-17
AU2024204350A1 (en) 2024-07-11

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