JP7142813B2 - アミコラトプシス・ルリダ由来シトクロムｐ４５０を用いた分岐状脂肪族または芳香族基質のヒドロキシ化法 - Google Patents

アミコラトプシス・ルリダ由来シトクロムｐ４５０を用いた分岐状脂肪族または芳香族基質のヒドロキシ化法 Download PDF

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JP7142813B2
JP7142813B2 JP2019547195A JP2019547195A JP7142813B2 JP 7142813 B2 JP7142813 B2 JP 7142813B2 JP 2019547195 A JP2019547195 A JP 2019547195A JP 2019547195 A JP2019547195 A JP 2019547195A JP 7142813 B2 JP7142813 B2 JP 7142813B2
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enzyme
cytochrome
ferredoxin
aluc09
hydroxylated
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JP2019536479A (ja
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チャールズ ポール スチール，ジョナサン
リソ，アントニオ デ
セント エドワード ウィリアムズ，ヘッドリー
ケリー フィップス，リチャード
キース リグリー，スティーブン
リンダ ニャチコ，キンガ
プーン，ビンセント
シュルツ，セバスチャン
マキシム ワード，ジョン
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ハイファ ディスカバリー リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/167—Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/66—Preparation of oxygen-containing organic compounds containing the quinoid structure

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  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2019547195A 2016-11-15 2017-11-15 アミコラトプシス・ルリダ由来シトクロムｐ４５０を用いた分岐状脂肪族または芳香族基質のヒドロキシ化法 Active JP7142813B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201619344 2016-11-15
GB1619344.3 2016-11-15
PCT/GB2017/053432 WO2018091885A1 (en) 2016-11-15 2017-11-15 Hydroxylation of branched aliphatic or aromatic substrates employing the amycolatopsis lurida cytochrome p450

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JP2019536479A JP2019536479A (ja) 2019-12-19
JP2019536479A5 JP2019536479A5 (enExample) 2020-12-24
JP7142813B2 true JP7142813B2 (ja) 2022-09-28

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EP (1) EP3541949A1 (enExample)
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WO (1) WO2018091885A1 (enExample)

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GB201807815D0 (en) * 2018-05-14 2018-06-27 Hypha Discovery Ltd Hydroxylation techniques
GB201819209D0 (en) 2018-11-26 2019-01-09 Hypha Discovery Ltd Biocatalytic techniques
GB201917077D0 (en) 2019-11-22 2020-01-08 Hypha Discovery Ltd Biocatalytic techniques
CN113072504B (zh) * 2021-03-29 2022-11-22 四川摩尔生物制药有限公司 一种波生坦代谢物的化学合成方法
GB202107512D0 (en) 2021-05-26 2021-07-07 Hypha Discovery Ltd Cytochrome P450 enzyme

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078978A1 (en) 2003-02-26 2004-09-16 Bristol-Myers Squibb Company Compositions and methods for hydroxylating epothilones
JP2005514031A (ja) 2001-12-26 2005-05-19 ブリストル−マイヤーズ　スクイブ　カンパニー エポチロンをヒドロキシル化するための組成物および方法
JP2006510386A (ja) 2002-12-17 2006-03-30 ブリストル−マイヤーズ　スクイブ　カンパニー エポチロンをヒドロキシル化するための方法および組成物
US20140038850A1 (en) 2011-02-11 2014-02-06 University Of Rochester Methods and systems for evaluating and predicting the reactivity of monooxygenase enzymes

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
WO2011038313A2 (en) 2009-09-25 2011-03-31 Regents Of The University Of Michigan Selective oxidation of c-h bonds of modified substrates by p450 monooxygenase
WO2013073775A1 (en) 2011-11-15 2013-05-23 Industry Foundation Of Chonnam National University Novel method for preparing metabolites of atorvastatin using bacterial cytochrome p450 and composition therefor
GB201807815D0 (en) * 2018-05-14 2018-06-27 Hypha Discovery Ltd Hydroxylation techniques

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005514031A (ja) 2001-12-26 2005-05-19 ブリストル−マイヤーズ　スクイブ　カンパニー エポチロンをヒドロキシル化するための組成物および方法
JP2006510386A (ja) 2002-12-17 2006-03-30 ブリストル−マイヤーズ　スクイブ　カンパニー エポチロンをヒドロキシル化するための方法および組成物
WO2004078978A1 (en) 2003-02-26 2004-09-16 Bristol-Myers Squibb Company Compositions and methods for hydroxylating epothilones
US20140038850A1 (en) 2011-02-11 2014-02-06 University Of Rochester Methods and systems for evaluating and predicting the reactivity of monooxygenase enzymes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Definition: cytochrome P450 [Amycolatopsis lurida NRRL 2430].，Database DDBJ/EMBL/GenBank [online]，Accession No.KFU83201，2014年09月05日，https://www.ncbi.nlm.nih.gov/protein/KFU83201

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JP2019536479A (ja) 2019-12-19
WO2018091885A1 (en) 2018-05-24
EP3541949A1 (en) 2019-09-25
US20190367957A1 (en) 2019-12-05
US11384371B2 (en) 2022-07-12

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