JP7142173B2 - ブルトン型チロシンキナーゼ阻害剤の投薬 - Google Patents

ブルトン型チロシンキナーゼ阻害剤の投薬 Download PDF

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Publication number
JP7142173B2
JP7142173B2 JP2021557408A JP2021557408A JP7142173B2 JP 7142173 B2 JP7142173 B2 JP 7142173B2 JP 2021557408 A JP2021557408 A JP 2021557408A JP 2021557408 A JP2021557408 A JP 2021557408A JP 7142173 B2 JP7142173 B2 JP 7142173B2
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JP2022518974A (ja
Inventor
ジーン ブランダーバー，バーバラ
チェン イー ク，ノラ
ナンダ，ニーシャ
オーガスト スミス，スティーブン
サイ，ドナルド
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Loxo Oncology Inc
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Loxo Oncology Inc
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Priority to JP2025044178A priority patent/JP2025098099A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021557408A 2019-12-06 2020-12-03 ブルトン型チロシンキナーゼ阻害剤の投薬 Active JP7142173B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022144243A JP7654604B2 (ja) 2019-12-06 2022-09-12 ブルトン型チロシンキナーゼ阻害剤の投薬
JP2025044178A JP2025098099A (ja) 2019-12-06 2025-03-19 ブルトン型チロシンキナーゼ阻害剤の投薬

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962944674P 2019-12-06 2019-12-06
US62/944,674 2019-12-06
US202063077996P 2020-09-14 2020-09-14
US63/077,996 2020-09-14
US202063109698P 2020-11-04 2020-11-04
US63/109,698 2020-11-04
PCT/US2020/063089 WO2021113497A1 (en) 2019-12-06 2020-12-03 Dosing of a bruton's tyrosine kinase inhibitor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022144243A Division JP7654604B2 (ja) 2019-12-06 2022-09-12 ブルトン型チロシンキナーゼ阻害剤の投薬

Publications (2)

Publication Number Publication Date
JP2022518974A JP2022518974A (ja) 2022-03-17
JP7142173B2 true JP7142173B2 (ja) 2022-09-26

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021557408A Active JP7142173B2 (ja) 2019-12-06 2020-12-03 ブルトン型チロシンキナーゼ阻害剤の投薬
JP2022144243A Active JP7654604B2 (ja) 2019-12-06 2022-09-12 ブルトン型チロシンキナーゼ阻害剤の投薬
JP2025044178A Pending JP2025098099A (ja) 2019-12-06 2025-03-19 ブルトン型チロシンキナーゼ阻害剤の投薬

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022144243A Active JP7654604B2 (ja) 2019-12-06 2022-09-12 ブルトン型チロシンキナーゼ阻害剤の投薬
JP2025044178A Pending JP2025098099A (ja) 2019-12-06 2025-03-19 ブルトン型チロシンキナーゼ阻害剤の投薬

Country Status (10)

Country Link
US (1) US20230041515A1 (enExample)
EP (1) EP4069219A1 (enExample)
JP (3) JP7142173B2 (enExample)
KR (2) KR20220100992A (enExample)
CN (1) CN115175677A (enExample)
AU (2) AU2020397034B2 (enExample)
BR (1) BR112022009716A2 (enExample)
IL (1) IL292882A (enExample)
MX (1) MX2022006631A (enExample)
WO (1) WO2021113497A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102653681B1 (ko) 2018-07-31 2024-04-03 록쏘 온콜로지, 인코포레이티드 (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의분무-건조된 분산물 및 제제
KR20220100992A (ko) * 2019-12-06 2022-07-18 록쏘 온콜로지, 인코포레이티드 브루톤 티로신 키나제 억제제의 투여

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018192462A1 (en) 2017-04-18 2018-10-25 Shanghai Fochon Pharmaceutical Co., Ltd. Apoptosis-inducing agents
JP2018538307A (ja) 2015-12-16 2018-12-27 ロクソ オンコロジー， インコーポレイテッドＬｏｘｏ Ｏｎｃｏｌｏｇｙ， Ｉｎｃ． キナーゼ阻害剤として有用な化合物
WO2019020606A1 (en) 2017-07-26 2019-01-31 F. Hoffmann-La Roche Ag POLYTHERAPY WITH BET INHIBITOR, BCL-2 INHIBITOR AND ANTI-CD20 ANTIBODY

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017132474A1 (en) 2016-01-30 2017-08-03 Newave Pharmaceutical Inc. Bcl-2 inhibitors
KR102429704B1 (ko) 2016-08-05 2022-08-04 더 리젠츠 오브 더 유니버시티 오브 미시건 Bcl-2 억제제로서의 n-(페닐설포닐)벤즈아미드 및 관련 화합물
WO2018127130A1 (en) 2017-01-07 2018-07-12 Shanghai Fochon Pharmaceutical Co., Ltd. Compounds as bcl-2-selective apoptosis-inducing agents
SG11202005985PA (en) 2018-01-10 2020-07-29 Recurium Ip Holdings Llc Benzamide compounds
FI3788042T3 (fi) 2018-04-29 2025-04-07 Beigene Switzerland Gmbh Bcl-2-inhibiittoreita
KR102653681B1 (ko) 2018-07-31 2024-04-03 록쏘 온콜로지, 인코포레이티드 (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의분무-건조된 분산물 및 제제
KR20220100992A (ko) * 2019-12-06 2022-07-18 록쏘 온콜로지, 인코포레이티드 브루톤 티로신 키나제 억제제의 투여

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018538307A (ja) 2015-12-16 2018-12-27 ロクソ オンコロジー， インコーポレイテッドＬｏｘｏ Ｏｎｃｏｌｏｇｙ， Ｉｎｃ． キナーゼ阻害剤として有用な化合物
WO2018192462A1 (en) 2017-04-18 2018-10-25 Shanghai Fochon Pharmaceutical Co., Ltd. Apoptosis-inducing agents
WO2019020606A1 (en) 2017-07-26 2019-01-31 F. Hoffmann-La Roche Ag POLYTHERAPY WITH BET INHIBITOR, BCL-2 INHIBITOR AND ANTI-CD20 ANTIBODY

Also Published As

Publication number Publication date
NZ788615A (en) 2024-10-25
KR20230127372A (ko) 2023-08-31
MX2022006631A (es) 2022-09-07
AU2024201263A1 (en) 2024-03-14
BR112022009716A2 (pt) 2022-08-09
JP2022518974A (ja) 2022-03-17
US20230041515A1 (en) 2023-02-09
AU2020397034A1 (en) 2022-07-21
JP2025098099A (ja) 2025-07-01
CA3160417A1 (en) 2021-06-10
KR20220100992A (ko) 2022-07-18
JP2022177119A (ja) 2022-11-30
WO2021113497A1 (en) 2021-06-10
CN115175677A (zh) 2022-10-11
AU2020397034B2 (en) 2023-12-07
JP7654604B2 (ja) 2025-04-01
AU2024201263B2 (en) 2025-05-01
EP4069219A1 (en) 2022-10-12
IL292882A (en) 2022-07-01

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