JP7116285B2 - Ｂｔｌａ融合タンパク質アゴニストおよびその使用 - Google Patents

Ｂｔｌａ融合タンパク質アゴニストおよびその使用 Download PDF

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JP7116285B2
JP7116285B2 JP2017568205A JP2017568205A JP7116285B2 JP 7116285 B2 JP7116285 B2 JP 7116285B2 JP 2017568205 A JP2017568205 A JP 2017568205A JP 2017568205 A JP2017568205 A JP 2017568205A JP 7116285 B2 JP7116285 B2 JP 7116285B2
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hvem
protein
btla
fusion protein
cells
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JP2018521999A (ja
JP2018521999A5 (enExample
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カール エフ． ウェアー，
ジョン セディー，
ティグラン アイバジアン，
ブライアン ミラー，
ナターシャ ケー． クレリン，
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サンフォード バーナム プレビーズ メディカル ディスカバリー インスティテュート
ファイザー・インク
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
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JP2017568205A 2015-06-30 2016-06-29 Ｂｔｌａ融合タンパク質アゴニストおよびその使用 Active JP7116285B2 (ja)

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JP2021083133A JP2021113240A (ja) 2015-06-30 2021-05-17 Ｂｔｌａ融合タンパク質アゴニストおよびその使用
JP2022115473A JP7559013B2 (ja) 2015-06-30 2022-07-20 Ｂｔｌａ融合タンパク質アゴニストおよびその使用
JP2023210069A JP2024019529A (ja) 2015-06-30 2023-12-13 Ｂｔｌａ融合タンパク質アゴニストおよびその使用

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US201562187105P 2015-06-30 2015-06-30
US62/187,105 2015-06-30
PCT/US2016/040108 WO2017004213A1 (en) 2015-06-30 2016-06-29 Btla fusion protein agonists and uses thereof

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JP2018521999A JP2018521999A (ja) 2018-08-09
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JP2022115473A Active JP7559013B2 (ja) 2015-06-30 2022-07-20 Ｂｔｌａ融合タンパク質アゴニストおよびその使用
JP2023210069A Pending JP2024019529A (ja) 2015-06-30 2023-12-13 Ｂｔｌａ融合タンパク質アゴニストおよびその使用

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JP2023210069A Pending JP2024019529A (ja) 2015-06-30 2023-12-13 Ｂｔｌａ融合タンパク質アゴニストおよびその使用

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US (3) US10961297B2 (enExample)
EP (1) EP3317297A4 (enExample)
JP (4) JP7116285B2 (enExample)
KR (2) KR20240110000A (enExample)
CN (2) CN114853903A (enExample)
AU (3) AU2016286108B2 (enExample)
BR (1) BR112017028316A2 (enExample)
CA (1) CA2990885A1 (enExample)
EA (1) EA201890171A1 (enExample)
IL (2) IL256383B2 (enExample)
MX (1) MX2018000073A (enExample)
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WO (1) WO2017004213A1 (enExample)

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JP2018521999A (ja) 2018-08-09
CN114853903A (zh) 2022-08-05
KR20240110000A (ko) 2024-07-12
SG10201913567QA (en) 2020-02-27
MX2018000073A (es) 2018-06-27
IL256383B2 (en) 2023-03-01
AU2016286108A1 (en) 2018-02-15
KR20180016618A (ko) 2018-02-14
US10961297B2 (en) 2021-03-30
BR112017028316A2 (en) 2018-09-04
IL256383A (en) 2018-02-28
IL256383B (en) 2022-11-01
IL297395B2 (en) 2024-01-01
CN108026159B9 (zh) 2022-07-05
US20180170999A1 (en) 2018-06-21
JP7559013B2 (ja) 2024-10-01
EP3317297A1 (en) 2018-05-09
WO2017004213A1 (en) 2017-01-05
US20240247047A1 (en) 2024-07-25
US20220025017A1 (en) 2022-01-27
IL297395A (en) 2022-12-01
KR102669985B1 (ko) 2024-05-29
AU2021203768B2 (en) 2023-01-19
AU2021203768A1 (en) 2021-07-08
CN108026159B (zh) 2022-05-27
JP2024019529A (ja) 2024-02-09
JP2022141840A (ja) 2022-09-29
EP3317297A4 (en) 2019-03-20
EA201890171A1 (ru) 2018-08-31
CN108026159A (zh) 2018-05-11
AU2016286108A8 (en) 2018-02-22
JP2021113240A (ja) 2021-08-05
IL297395B1 (en) 2023-09-01
AU2016286108B2 (en) 2021-03-11
AU2023202302A1 (en) 2023-05-11
US11939367B2 (en) 2024-03-26

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