JP7111811B2 - がんの治療に使用するためのミルシクリブの製剤及びその治療的組み合わせ - Google Patents

がんの治療に使用するためのミルシクリブの製剤及びその治療的組み合わせ Download PDF

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JP7111811B2
JP7111811B2 JP2020524839A JP2020524839A JP7111811B2 JP 7111811 B2 JP7111811 B2 JP 7111811B2 JP 2020524839 A JP2020524839 A JP 2020524839A JP 2020524839 A JP2020524839 A JP 2020524839A JP 7111811 B2 JP7111811 B2 JP 7111811B2
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milciclib
cancer
pharmaceutical composition
pharmaceutically acceptable
sorafenib
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JP2021509395A (ja
JP2021509395A5 (https=
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シャイルバイ クンワー
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ティジアーナ ライフ サイエンシズ パブリック リミティド カンパニー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
JP2020524839A 2017-11-06 2018-11-06 がんの治療に使用するためのミルシクリブの製剤及びその治療的組み合わせ Active JP7111811B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022116328A JP2022136148A (ja) 2017-11-06 2022-07-21 がんの治療に使用するためのミルシクリブの製剤及びその治療的組み合わせ
JP2024108704A JP2024128026A (ja) 2017-11-06 2024-07-05 がんの治療に使用するためのミルシクリブの製剤及びその治療的組み合わせ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762582288P 2017-11-06 2017-11-06
US62/582,288 2017-11-06
PCT/US2018/059451 WO2019090332A1 (en) 2017-11-06 2018-11-06 Formulations of milciclib and therapeutic combinations of the same for use in the treatment of cancer

Related Child Applications (1)

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JP2022116328A Division JP2022136148A (ja) 2017-11-06 2022-07-21 がんの治療に使用するためのミルシクリブの製剤及びその治療的組み合わせ

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JP2021509395A JP2021509395A (ja) 2021-03-25
JP2021509395A5 JP2021509395A5 (https=) 2021-12-16
JP7111811B2 true JP7111811B2 (ja) 2022-08-02

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JP2020524839A Active JP7111811B2 (ja) 2017-11-06 2018-11-06 がんの治療に使用するためのミルシクリブの製剤及びその治療的組み合わせ
JP2022116328A Pending JP2022136148A (ja) 2017-11-06 2022-07-21 がんの治療に使用するためのミルシクリブの製剤及びその治療的組み合わせ
JP2024108704A Pending JP2024128026A (ja) 2017-11-06 2024-07-05 がんの治療に使用するためのミルシクリブの製剤及びその治療的組み合わせ

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JP2022116328A Pending JP2022136148A (ja) 2017-11-06 2022-07-21 がんの治療に使用するためのミルシクリブの製剤及びその治療的組み合わせ
JP2024108704A Pending JP2024128026A (ja) 2017-11-06 2024-07-05 がんの治療に使用するためのミルシクリブの製剤及びその治療的組み合わせ

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US (3) US10758541B2 (https=)
EP (1) EP3706869A1 (https=)
JP (3) JP7111811B2 (https=)
CA (2) CA3292080A1 (https=)
WO (1) WO2019090332A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019178239A1 (en) * 2018-03-13 2019-09-19 Board Of Regents, The University Of Texas System Methods for treatment of cancers with egfr activating mutations
JP7642556B2 (ja) * 2019-11-18 2025-03-10 中外製薬株式会社 併用医薬
CN110693839B (zh) * 2019-11-19 2022-03-08 乐普药业股份有限公司 一种甲磺酸仑伐替尼固体分散体及其制备方法和用途
CN112218626B (zh) * 2019-12-31 2023-03-24 广州帝奇医药技术有限公司 一种持续释放组合物及其制备方法
JP2021167301A (ja) * 2020-04-08 2021-10-21 ファイザー・インク Ｃｄｋ２阻害剤に対する腫瘍適応を抑制するためのｃｄｋ４／６およびｃｄｋ２阻害剤による同時処置
CN112546048B (zh) * 2021-01-06 2022-11-29 天津科技大学 HKL-5-61与Osimertinib的药物组合及其应用
KR102597832B1 (ko) * 2021-01-19 2023-11-02 인천대학교 산학협력단 소라페닙의 항암효과 증진용 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011529474A (ja) 2008-07-29 2011-12-08 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ ｃｄｋ阻害剤および抗悪性腫瘍剤を含む治療用組合せ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
BRPI0707580A2 (pt) * 2006-02-10 2011-05-10 Nerviano Medical Sciences Srl combinaÇÕes compreendendo um inibidor cdk e um anticorpo do fator de crescimento ou antimitàtico
WO2016015605A1 (en) 2014-07-26 2016-02-04 Sunshine Lake Pharma Co., Ltd. Compounds as cdk small-molecule inhibitors and uses thereof
EP3233918A1 (en) * 2014-12-19 2017-10-25 Novartis AG Combination therapies

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011529474A (ja) 2008-07-29 2011-12-08 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ ｃｄｋ阻害剤および抗悪性腫瘍剤を含む治療用組合せ

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Cancer Chemother Pharmacol，2017年，Vol.79，p.1257-1265
Hepatic Oncol.，2014年，Vol.1, No.1，p.23-38

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Publication number Publication date
JP2024128026A (ja) 2024-09-20
US20190134044A1 (en) 2019-05-09
JP2021509395A (ja) 2021-03-25
CA3076023C (en) 2026-04-07
JP2022136148A (ja) 2022-09-15
US20200390769A1 (en) 2020-12-17
WO2019090332A1 (en) 2019-05-09
EP3706869A1 (en) 2020-09-16
CA3292080A1 (en) 2026-03-02
US10758541B2 (en) 2020-09-01
US20240285632A1 (en) 2024-08-29
CA3076023A1 (en) 2019-05-09

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