JP7107950B2 - 特定のｖｍａｔ２インヒビターを投与するための方法 - Google Patents

特定のｖｍａｔ２インヒビターを投与するための方法 Download PDF

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JP7107950B2
JP7107950B2 JP2019540650A JP2019540650A JP7107950B2 JP 7107950 B2 JP7107950 B2 JP 7107950B2 JP 2019540650 A JP2019540650 A JP 2019540650A JP 2019540650 A JP2019540650 A JP 2019540650A JP 7107950 B2 JP7107950 B2 JP 7107950B2
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JP2020505408A (ja
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クリストファー エフ． オブライエン，
ヘイグ ピー． ボゼジアン，
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ニューロクライン バイオサイエンシーズ，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems

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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
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JP2019540650A 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法 Active JP7107950B2 (ja)

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JP2022113075A JP2022137219A (ja) 2017-01-27 2022-07-14 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024093040A JP7828390B2 (ja) 2017-01-27 2024-06-07 特定のｖｍａｔ２インヒビターを投与するための方法

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US201762451605P 2017-01-27 2017-01-27
US62/451,605 2017-01-27
PCT/US2017/055965 WO2018140095A2 (en) 2017-01-27 2017-10-10 Methods for the administration of certain vmat2 inhibitors

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JP2020505408A JP2020505408A (ja) 2020-02-20
JP2020505408A5 JP2020505408A5 (https=) 2020-11-19
JP7107950B2 true JP7107950B2 (ja) 2022-07-27

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JP2019540650A Active JP7107950B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2019540570A Active JP7199361B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2019540557A Active JP7199359B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2020520311A Active JP7090151B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2019540568A Active JP7199360B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022008580A Withdrawn JP2022040408A (ja) 2017-01-27 2022-01-24 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022113075A Withdrawn JP2022137219A (ja) 2017-01-27 2022-07-14 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022160177A Withdrawn JP2022174343A (ja) 2017-01-27 2022-10-04 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022160833A Withdrawn JP2022174345A (ja) 2017-01-27 2022-10-05 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022160831A Withdrawn JP2022174344A (ja) 2017-01-27 2022-10-05 特定のｖｍａｔ２インヒビターを投与するための方法
JP2023149999A Pending JP2023161033A (ja) 2017-01-27 2023-09-15 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024092152A Pending JP2024107168A (ja) 2017-01-27 2024-06-06 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024092148A Pending JP2024107167A (ja) 2017-01-27 2024-06-06 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024092155A Pending JP2024107169A (ja) 2017-01-27 2024-06-06 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024093040A Active JP7828390B2 (ja) 2017-01-27 2024-06-07 特定のｖｍａｔ２インヒビターを投与するための方法
JP2025126262A Pending JP2025146959A (ja) 2017-01-27 2025-07-29 特定のｖｍａｔ２インヒビターを投与するための方法

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JP2019540570A Active JP7199361B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2019540557A Active JP7199359B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2020520311A Active JP7090151B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2019540568A Active JP7199360B2 (ja) 2017-01-27 2017-10-10 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022008580A Withdrawn JP2022040408A (ja) 2017-01-27 2022-01-24 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022113075A Withdrawn JP2022137219A (ja) 2017-01-27 2022-07-14 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022160177A Withdrawn JP2022174343A (ja) 2017-01-27 2022-10-04 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022160833A Withdrawn JP2022174345A (ja) 2017-01-27 2022-10-05 特定のｖｍａｔ２インヒビターを投与するための方法
JP2022160831A Withdrawn JP2022174344A (ja) 2017-01-27 2022-10-05 特定のｖｍａｔ２インヒビターを投与するための方法
JP2023149999A Pending JP2023161033A (ja) 2017-01-27 2023-09-15 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024092152A Pending JP2024107168A (ja) 2017-01-27 2024-06-06 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024092148A Pending JP2024107167A (ja) 2017-01-27 2024-06-06 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024092155A Pending JP2024107169A (ja) 2017-01-27 2024-06-06 特定のｖｍａｔ２インヒビターを投与するための方法
JP2024093040A Active JP7828390B2 (ja) 2017-01-27 2024-06-07 特定のｖｍａｔ２インヒビターを投与するための方法
JP2025126262A Pending JP2025146959A (ja) 2017-01-27 2025-07-29 特定のｖｍａｔ２インヒビターを投与するための方法

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US (10) US10874648B2 (https=)
JP (16) JP7107950B2 (https=)
KR (14) KR20190108146A (https=)
CN (6) CN110709071A (https=)
AU (7) AU2017395703B2 (https=)
CA (5) CA3051829A1 (https=)
EA (5) EA201991780A1 (https=)
MX (6) MX394417B (https=)
MY (5) MY199695A (https=)
PH (6) PH12022553251A1 (https=)
SG (3) SG11201906883SA (https=)
WO (5) WO2018140092A1 (https=)

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