JP7086945B2 - 狼瘡を処置するための化合物および方法 - Google Patents

狼瘡を処置するための化合物および方法 Download PDF

Info

Publication number
JP7086945B2
JP7086945B2 JP2019517027A JP2019517027A JP7086945B2 JP 7086945 B2 JP7086945 B2 JP 7086945B2 JP 2019517027 A JP2019517027 A JP 2019517027A JP 2019517027 A JP2019517027 A JP 2019517027A JP 7086945 B2 JP7086945 B2 JP 7086945B2
Authority
JP
Japan
Prior art keywords
compound
groups
dihydro
alkyl
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019517027A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019529487A5 (OSRAM
JP2019529487A (ja
Inventor
フィオナ ロレイン スコット，
クリステン アール． テイラー メドース，
ロバート ピーチ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Receptos LLC
Original Assignee
Receptos LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Receptos LLC filed Critical Receptos LLC
Publication of JP2019529487A publication Critical patent/JP2019529487A/ja
Publication of JP2019529487A5 publication Critical patent/JP2019529487A5/ja
Application granted granted Critical
Publication of JP7086945B2 publication Critical patent/JP7086945B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019517027A 2016-09-29 2017-09-28 狼瘡を処置するための化合物および方法 Active JP7086945B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662401762P 2016-09-29 2016-09-29
US62/401,762 2016-09-29
PCT/US2017/054053 WO2018064356A1 (en) 2016-09-29 2017-09-28 Compounds and methods for treating lupus

Publications (3)

Publication Number Publication Date
JP2019529487A JP2019529487A (ja) 2019-10-17
JP2019529487A5 JP2019529487A5 (OSRAM) 2020-09-10
JP7086945B2 true JP7086945B2 (ja) 2022-06-20

Family

ID=60043386

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019517027A Active JP7086945B2 (ja) 2016-09-29 2017-09-28 狼瘡を処置するための化合物および方法

Country Status (6)

Country Link
US (1) US11278526B2 (OSRAM)
EP (1) EP3518922A1 (OSRAM)
JP (1) JP7086945B2 (OSRAM)
KR (1) KR102408814B1 (OSRAM)
CA (1) CA3038106A1 (OSRAM)
WO (1) WO2018064356A1 (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201992421A1 (ru) * 2017-05-22 2020-03-27 Эгиш Дьёдьсердьяр Зрт. Способ получения озанимода
AR116479A1 (es) * 2018-09-25 2021-05-12 Quim Sintetica S A Intermediarios para la síntesis de ozanimod y procedimiento para la preparación del mencionado agonista del receptor de esfingosina-1-fosfato y de dichos intermediarios
EP3947363A4 (en) * 2019-03-29 2023-01-04 Receptos Llc SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORS
CN116332794B (zh) * 2021-12-24 2024-10-15 上海合全药物研发有限公司 一种芳基腈类化合物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1893591A1 (en) 2005-06-08 2008-03-05 Novartis AG POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS
CA2664268A1 (en) 2006-09-29 2008-04-03 Novartis Ag Diaryl oxadiazol derivatives
JO2701B1 (en) 2006-12-21 2013-03-03 جلاكسو جروب ليميتد Vehicles
MY156381A (en) 2008-05-14 2016-02-15 Scripps Research Inst Novel modulators of sphingosine phosphate receptors
MY161854A (en) * 2009-11-13 2017-05-15 Receptos Inc Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
EP3062792A1 (en) * 2013-11-01 2016-09-07 Celgene International II Sarl Selective sphingosine 1 phosphate receptor modulators and combination therapy therewith

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
British Journal of Pharmacology，2016年06月，Vol.173，p.1778-1792
F1000Prime Reports，2014年，Vol.6:109，p.1-7

Also Published As

Publication number Publication date
US11278526B2 (en) 2022-03-22
WO2018064356A1 (en) 2018-04-05
KR20190060791A (ko) 2019-06-03
KR102408814B1 (ko) 2022-06-14
US20190224172A1 (en) 2019-07-25
JP2019529487A (ja) 2019-10-17
EP3518922A1 (en) 2019-08-07
CA3038106A1 (en) 2018-04-05

Similar Documents

Publication Publication Date Title
EP3983384B1 (en) N-(phenyl)-indole-3-sulfonamide derivatives and related compounds as gpr17 modulators for treating cns disorders such as multiple sclerosis
US11207301B2 (en) Sphingosine 1 phosphate receptor agonists for neuroprotection
JP5988379B2 (ja) スフィンゴシン−１−リン酸受容体変調因子および不斉合成方法
JP7086945B2 (ja) 狼瘡を処置するための化合物および方法
CN110325531B (zh) 苯磺酰胺及其作为治疗剂的用途
JP2006528980A (ja) Ｓ１ｐ受容体作働薬としての３−（２−アミノ−１−アザシクロ）−５−アリール−１，２，４−オキサジアゾール類
EP3022175A1 (en) Sulfonamides as modulators of sodium channels
TW201329050A (zh) Ｔｒｐｖ１拮抗劑
JP6627835B2 (ja) Ｋｃｎｑ２〜５チャネル活性化剤
CN104010501B (zh) 含src同源区2蛋白酪胺酸磷酸酶-1增效剂及其治疗方法
JP2004522710A (ja) 性機能障害の治療
RU2382029C2 (ru) Новые производные циклогексана
RU2457201C2 (ru) (2r)-2-[(4-сульфонил)аминофенил]пропанамиды и содержащие их фармацевтические композиции
CN110234643A (zh) RORγ调节剂及其用途
JP6197971B1 (ja) Ｋｃｎｑ２〜５チャネル関連疾患の予防および／または治療剤
EP3573974A1 (en) Rorgamma modulators and uses thereof
TW200804327A (en) Preventives/remedies for urinary disturbance
JPWO2017131097A1 (ja) アダマンタン誘導体およびその使用
JP2023103371A (ja) 新規の芳香族化合物
WO2018138354A1 (en) Rorgamma modulators and uses thereof
JP6265313B1 (ja) Ｋｃｎｑ２〜５チャネル活性化剤の結晶多形
TW201940476A (zh) 環狀胺衍生物及其醫藥用途
JP2000273076A (ja) レチノイド作用物質

Legal Events

Date Code Title Description
RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20200214

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20200226

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200728

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200728

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20210421

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210518

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210817

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20211116

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220316

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20220316

C11 Written invitation by the commissioner to file amendments

Free format text: JAPANESE INTERMEDIATE CODE: C11

Effective date: 20220329

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20220419

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20220516

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20220517

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220531

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220608

R150 Certificate of patent or registration of utility model

Ref document number: 7086945

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250