JP7080053B2 - 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 - Google Patents

腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 Download PDF

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JP7080053B2
JP7080053B2 JP2017511675A JP2017511675A JP7080053B2 JP 7080053 B2 JP7080053 B2 JP 7080053B2 JP 2017511675 A JP2017511675 A JP 2017511675A JP 2017511675 A JP2017511675 A JP 2017511675A JP 7080053 B2 JP7080053 B2 JP 7080053B2
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kynureninase
cell
tumor
enzyme
cells
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JP2017526368A (ja
JP2017526368A5 (enExample
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ジョージ ジョージウー
エバレット ストーン
ニコラス マーシャル
ジョン ブラゼック
ウェイ‐チェン ルー
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University of Texas System
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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    • C12Y307/00—Hydrolases acting on carbon-carbon bonds (3.7)
    • C12Y307/01—Hydrolases acting on carbon-carbon bonds (3.7) in ketonic substances (3.7.1)
    • C12Y307/01003—Kynureninase (3.7.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif

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  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2017511675A 2014-08-29 2015-08-28 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 Active JP7080053B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462043663P 2014-08-29 2014-08-29
US62/043,663 2014-08-29
US201562120418P 2015-02-25 2015-02-25
US62/120,418 2015-02-25
PCT/US2015/047475 WO2016033488A1 (en) 2014-08-29 2015-08-28 Administration of kynurenine depleting enzymes for tumor therapy

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JP2020159230A Division JP2021006046A (ja) 2014-08-29 2020-09-24 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与

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JP2017526368A JP2017526368A (ja) 2017-09-14
JP2017526368A5 JP2017526368A5 (enExample) 2018-10-04
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JP2020159230A Pending JP2021006046A (ja) 2014-08-29 2020-09-24 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与

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EP (1) EP3186371B1 (enExample)
JP (2) JP7080053B2 (enExample)
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ES (1) ES2987380T3 (enExample)
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JP7080053B2 (ja) 2014-08-29 2022-06-03 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与
EP3402498A1 (en) * 2016-01-11 2018-11-21 Synlogic, Inc. Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
WO2017136795A1 (en) 2016-02-04 2017-08-10 Synlogic, Inc. Bacteria engineered to treat diseases associated with tryptophan metabolism
US11542486B2 (en) 2016-03-02 2023-01-03 Board Of Regents, The University Of Texas System Human kynureninase enzyme variants having improved pharmacological properties
MA46649A (fr) 2016-10-13 2019-08-21 Juno Therapeutics Inc Méthodes et compositions d'immunothérapie impliquant des modulateurs de la voie métabolique du tryptophane
MX2019008196A (es) 2017-01-06 2019-12-16 Synlogic Operating Co Inc Microorganismos programados para producir moduladores inmunes y productos terapéuticos anti-cáncer en células tumorales.
TWI827593B (zh) * 2018-04-16 2024-01-01 美國德州系統大學評議委員會 人類犬尿胺酸酶及其用途
AU2020366452A1 (en) * 2019-10-17 2022-05-05 The Board Of Regents Of The University Of Texas System Pegylated kynureninase enzymes and uses thereof for the treatment of cancer
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US11542486B2 (en) * 2016-03-02 2023-01-03 Board Of Regents, The University Of Texas System Human kynureninase enzyme variants having improved pharmacological properties
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JP6307163B2 (ja) 2013-08-30 2018-04-04 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与

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Ｂｉｏｃｈｅｍｉｓｔｒｙ，２００７年，Ｖｏｌ．４６，ｐ．２７３５－２７４４

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WO2016033488A1 (en) 2016-03-03
JP2021006046A (ja) 2021-01-21
US20220275099A1 (en) 2022-09-01
IL250833A0 (en) 2017-04-30
US9975959B2 (en) 2018-05-22
EP3186371A1 (en) 2017-07-05
IL250833B (en) 2022-09-01
JP2017526368A (ja) 2017-09-14
ES2987380T3 (es) 2024-11-14
US11168142B2 (en) 2021-11-09
EP3186371A4 (en) 2018-01-10
US20160058845A1 (en) 2016-03-03
CA2959508A1 (en) 2016-03-03
US20190002579A1 (en) 2019-01-03

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