JP7068706B2 - 網膜神経変性疾患の眼局所治療のためのジペプチジルペプチダーゼ－４阻害剤 - Google Patents

網膜神経変性疾患の眼局所治療のためのジペプチジルペプチダーゼ－４阻害剤 Download PDF

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JP7068706B2
JP7068706B2 JP2018555725A JP2018555725A JP7068706B2 JP 7068706 B2 JP7068706 B2 JP 7068706B2 JP 2018555725 A JP2018555725 A JP 2018555725A JP 2018555725 A JP2018555725 A JP 2018555725A JP 7068706 B2 JP7068706 B2 JP 7068706B2
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カノンジェ，ラファエル シモ
パスクアル，クリスティーナ エルナンデス
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フンダシオ オスピタル ウニベルシタリ バル デブロン－インスティテュート デ レセルカ
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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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JP2018555725A 2016-04-29 2017-04-28 網膜神経変性疾患の眼局所治療のためのジペプチジルペプチダーゼ－４阻害剤 Active JP7068706B2 (ja)

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EP16382190 2016-04-29
EP16382190.3 2016-04-29
PCT/EP2017/060234 WO2017186934A1 (en) 2016-04-29 2017-04-28 Dipeptidyl peptidase-4 inhibitors for topical eye treatment of retinal neurodegenerative diseases

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JP2019519479A JP2019519479A (ja) 2019-07-11
JP2019519479A5 JP2019519479A5 (https=) 2020-06-11
JP7068706B2 true JP7068706B2 (ja) 2022-05-17

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US (2) US11013738B2 (https=)
EP (1) EP3448388B1 (https=)
JP (1) JP7068706B2 (https=)
KR (1) KR102411574B1 (https=)
CN (1) CN109152776B (https=)
AU (1) AU2017256803B2 (https=)
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JP7068706B2 (ja) * 2016-04-29 2022-05-17 フンダシオ オスピタル ウニベルシタリ バル デブロン－インスティテュート デ レセルカ 網膜神経変性疾患の眼局所治療のためのジペプチジルペプチダーゼ－４阻害剤
RU2727898C1 (ru) * 2020-02-25 2020-07-24 Общество с ограниченной ответственностью «Необиотек» Фармацевтическая композиция на основе действующего вещества, ингибитора дипептидилпептидазы-4, для предупреждения развития и лечения сахарного диабета 2 типа
CN111166870A (zh) * 2020-03-18 2020-05-19 复旦大学附属眼耳鼻喉科医院 艾塞那肽在制备滴眼治疗眼部缺血疾病、改善眼部血液循环的药物中的应用
GB202014740D0 (en) * 2020-09-18 2020-11-04 Invex Therapeutics Ltd Method of reducing intraocular pressure
WO2026078034A1 (en) 2024-10-09 2026-04-16 Fundació Hospital Universitari Vall D'hebron - Institut De Recerca Sitagliptin for use in retinal diseases with neovascularization

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US20100317856A1 (en) 2007-11-02 2010-12-16 Glenmark Generics Ltd Process for the preparation of r-sitagliptin and its pharmaceutically acceptable salts thereof
JP2011510986A (ja) 2008-02-05 2011-04-07 メルク・シャープ・エンド・ドーム・コーポレイション メトホルミン及びジペプチジルペプチダーゼ−ｉｖ阻害剤の併用医薬組成物
JP2012526524A (ja) 2009-05-12 2012-11-01 バイオコンパティブルズ ユーケー リミテッド 神経保護因子及び抗血管新生因子の少なくともいずれかをコードし且つ分泌するカプセル化された細胞を用いる眼疾患の治療
JP2015518002A (ja) 2012-04-25 2015-06-25 イノボバイオロジック， インコーポレイテッド 代謝疾患の処置のための食物繊維組成物

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US20100317856A1 (en) 2007-11-02 2010-12-16 Glenmark Generics Ltd Process for the preparation of r-sitagliptin and its pharmaceutically acceptable salts thereof
JP2011510986A (ja) 2008-02-05 2011-04-07 メルク・シャープ・エンド・ドーム・コーポレイション メトホルミン及びジペプチジルペプチダーゼ−ｉｖ阻害剤の併用医薬組成物
JP2012526524A (ja) 2009-05-12 2012-11-01 バイオコンパティブルズ ユーケー リミテッド 神経保護因子及び抗血管新生因子の少なくともいずれかをコードし且つ分泌するカプセル化された細胞を用いる眼疾患の治療
JP2015518002A (ja) 2012-04-25 2015-06-25 イノボバイオロジック， インコーポレイテッド 代謝疾患の処置のための食物繊維組成物

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WO2017186934A1 (en) 2017-11-02
US11918577B2 (en) 2024-03-05
EP3448388B1 (en) 2020-11-18
MX383599B (es) 2025-03-14
BR112018072127A2 (pt) 2019-03-19
IL262526B (en) 2022-05-01
KR102411574B1 (ko) 2022-06-21
CA3022152A1 (en) 2017-11-02
EP3448388A1 (en) 2019-03-06
AU2017256803B2 (en) 2022-12-01
RU2018140127A (ru) 2020-05-29
US11013738B2 (en) 2021-05-25
JP2019519479A (ja) 2019-07-11
CA3022152C (en) 2024-10-29
ES2863701T3 (es) 2021-10-11
KR20190003575A (ko) 2019-01-09
DK3448388T3 (da) 2021-02-08
US20210315890A1 (en) 2021-10-14
CN109152776B (zh) 2022-04-29
IL262526A (en) 2018-12-31
US20190134030A1 (en) 2019-05-09
AU2017256803A1 (en) 2018-12-06
RU2744878C2 (ru) 2021-03-16

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