JP7065942B2 - すくみ足の患者向けの治療的電気刺激療法 - Google Patents
すくみ足の患者向けの治療的電気刺激療法 Download PDFInfo
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- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
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- A61N1/02—Details
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Description
[0090]図5に示すように、プロセッサ40は、刺激発生装置44およびリード20A~20Bに沿って設けられた電極24、26を介した、第1の電気刺激治療の患者12への送達を制御する(500)。一例では、第1の電気刺激は、すくみ足以外の疾患の症状を抑制するように構成される。たとえば、第1の電気刺激は、動作緩慢、硬直、または振戦などのすくみ足以外の患者12のパーキンソン病の症状を抑制するように構成することができる。いくつかの例では、第1の電気刺激は、約130ヘルツ~約185ヘルツの範囲から選択される第1の周波数を有する。
Claims (11)
- 患者がすくみ足(freezing of gait)に関連付けられる運動を行っている間に前記患者の脳の生体電気信号を検知するように構成された1つまたは複数の電極と、
1つまたは複数のプロセッサであって、
前記生体電気信号に基づいて、前記患者がすくみ足の発現を経験していない間に前記患者がすくみ足になりやすいことを判定し、
前記判定に基づいて、すくみ足に関連付けられる運動が検出されるとすくみ足を抑制するように構成された電気刺激治療を前記患者に送達するよう医療装置をプログラムするように構成された、
1つまたは複数のプロセッサと
を備え、
前記患者がすくみ足になりやすいことを前記生体電気信号に基づいて判定するために、前記1つまたは複数のプロセッサは、
前記患者が動いている間に検知された前記生体電気信号の振幅が、前記患者が運動していない間に検知された前記生体電気信号の振幅よりも実質的に小さいと判定されると、前記患者がすくみ足になりやすいと判定するようにさらに構成されており、
前記1つまたは複数のプロセッサが、
前記医療装置による第1の周波数での第1の電気刺激治療の前記患者への送達を制御し、
すくみ足に関連付けられる運動を検出し、
すくみ足に関連付けられる運動が検出されたのに応答して、前記医療装置による前記第1の周波数での前記第1の電気刺激治療の前記患者への送達を制御することから、前記医療装置による第2の周波数での第2の電気刺激治療の前記患者への送達を制御することへと切り換えるようにさらに構成されている、
医療システム。 - 患者の脳の前記生体電気信号を検知するために、前記1つまたは複数の電極が、
前記患者が運動していない間に前記生体電気信号を検知し、
前記患者がすくみ足に関連付けられる運動を行っている間に前記生体電気信号を検知するようにさらに構成された、
請求項1に記載の医療システム。 - すくみ足に関連付けられる運動が、方向転換運動(turning movement)、足踏み(stepping)運動、または起立(standing)運動から足踏み運動への移行のうちの少なくとも1つを含む、請求項1又は2のいずれかに記載の医療システム。
- 前記患者の前記脳の前記生体電気信号が、約11ヘルツ~約30ヘルツの周波数を含む前記患者の前記脳のベータ信号である、請求項1から3のいずれかに記載の医療システム。
- 患者の脳の前記生体電気信号を検知するために、前記1つまたは複数の電極が、前記患者の前記脳の局所フィールド電位(LFP)を検知するようにさらに構成されている、請求項1から4のいずれかに記載の医療システム。
- 前記生体電気信号が、前記患者のすくみ足に関連付けられるバイオマーカである、請求項1から5のいずれかに記載の医療システム。
- 前記第1の周波数が約130ヘルツ~約185ヘルツの範囲から選択され、
前記第2の周波数が約60ヘルツ~約70ヘルツの範囲から選択される、
請求項1に記載の医療システム。 - 前記第2の電気刺激治療が、前記患者のパーキンソン病によるすくみ足を抑制するように構成され、
前記第1の電気刺激治療が、すくみ足以外の、前記患者のパーキンソン病の1つまたは複数の症状を抑制するように構成される、
請求項1または7に記載の医療システム。 - 前記1つまたは複数のプロセッサが、
すくみ足に関連付けられる運動の中止を検出し、
すくみ足に関連付けられる運動の中止が検出されたのに応答して、前記第2の周波数での前記第2の電気刺激治療の前記患者への送達から、前記第1の周波数での前記第1の電気刺激治療の前記患者への送達へと切り換えるようにさらに構成されている、
請求項1から8のいずれかに記載の医療システム。 - 命令を含む一時的でないコンピュータ可読媒体であって、前記命令は、実行されると、1つまたは複数のプロセッサに、
患者がすくみ足に関連付けられる運動を行っている間、1つまたは複数の電極を介して前記患者の脳の生体電気信号を検知させ、
前記生体電気信号に基づいて、前記患者がすくみ足の発現を経験していない間に前記患者がすくみ足になりやすいことを判定させ、
前記判定に基づいて、すくみ足に関連付けられる運動が検出されるとすくみ足を抑制するように構成された電気刺激治療を前記患者に送達するよう医療装置をプログラムさせ、
前記患者がすくみ足になりやすいことを前記生体電気信号に基づいて判定するために、前記1つまたは複数のプロセッサは、
前記患者が動いている間に検知された前記生体電気信号の振幅が、前記患者が運動していない間に検知された前記生体電気信号の振幅よりも実質的に小さいと判定されると、前記患者がすくみ足になりやすいと判定し、
前記命令がさらに、前記1つまたは複数のプロセッサに、
第1の周波数で第1の電気刺激治療を前記患者に送達するよう前記医療装置を制御させ、
すくみ足に関連付けられる運動を検出させ、
すくみ足に関連付けられる運動が検出されたのに応答して、前記第1の周波数で前記第1の電気刺激治療を前記患者に送達するよう前記医療装置を制御することから、第2の周波数で第2の電気刺激治療を前記患者に送達するよう前記医療装置を制御することへと切り換えさせる、
コンピュータ可読媒体。 - 患者がすくみ足に関連付けられる運動を行っている間に前記患者の脳の生体電気信号を検知するための手段と、
前記生体電気信号に基づいて、前記患者がすくみ足の発現を経験していない間に前記患者がすくみ足になりやすいことを判定するための手段と、
前記判定に基づいて、すくみ足に関連付けられる運動が検出されるとすくみ足を抑制するように構成された電気刺激治療を前記患者に送達するよう医療装置をプログラムするための手段と
を備え、
更に、
前記患者がすくみ足になりやすいことを前記生体電気信号に基づいて判定するための、
前記患者が動いている間に検知された前記生体電気信号の振幅が、前記患者が運動していない間に検知された前記生体電気信号の振幅よりも実質的に小さいと判定されると、前記患者がすくみ足になりやすいと判定するための手段と、
第1の周波数で第1の電気刺激治療を前記患者に送達するよう前記医療装置を制御するための手段と、
すくみ足に関連付けられる運動を検出するための手段と、
すくみ足に関連付けられる運動が検出されたのに応答して、前記第1の周波数で前記第1の電気刺激治療を前記患者に送達するよう前記医療装置を制御することから、第2の周波数で第2の電気刺激治療を前記患者に送達するよう前記医療装置を制御することへと切り換えるための手段と、
を備える、医療システム。
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Application Number | Priority Date | Filing Date | Title |
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US15/664,798 US11596795B2 (en) | 2017-07-31 | 2017-07-31 | Therapeutic electrical stimulation therapy for patient gait freeze |
US15/664,798 | 2017-07-31 | ||
PCT/US2018/027144 WO2019027512A1 (en) | 2017-07-31 | 2018-04-11 | THERAPEUTIC ELECTRICAL STIMULATION THERAPY FOR BRUTAL BLOCKING AT THE INTRODUCTION OF A PATIENT'S MARKET |
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JP2020529877A JP2020529877A (ja) | 2020-10-15 |
JP7065942B2 true JP7065942B2 (ja) | 2022-05-12 |
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US (1) | US11596795B2 (ja) |
EP (1) | EP3661591B1 (ja) |
JP (1) | JP7065942B2 (ja) |
CN (1) | CN110944711B (ja) |
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DE102019214752B4 (de) | 2019-09-26 | 2022-12-15 | CereGate GmbH | Neuronales signalsystem, verfahren und computerprogramm zumsignalisieren eines gerätezustands |
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CN112618949A (zh) * | 2019-10-08 | 2021-04-09 | 苏州景昱医疗器械有限公司 | 用于植入式医疗设备的连接器组件及其制造方法 |
WO2021150660A1 (en) * | 2020-01-23 | 2021-07-29 | The Cleveland Clinic Foundation | Configuring a deep brain stimulation (dbs) system to treat a neurological disorder |
DE102020210676B4 (de) | 2020-08-21 | 2024-08-01 | CereGate GmbH | Closed-loop computer-gehirn-schnittstellenvorrichtung |
US12109417B2 (en) * | 2021-02-01 | 2024-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for deep brain stimulation using kinematic feedback for treatment of movement disorders |
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US11596795B2 (en) | 2023-03-07 |
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US20190030338A1 (en) | 2019-01-31 |
EP3661591A1 (en) | 2020-06-10 |
CN110944711B (zh) | 2023-11-28 |
EP3661591B1 (en) | 2024-05-29 |
CN110944711A (zh) | 2020-03-31 |
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