JP7060121B2 - Multi-chamber container for freezing - Google Patents

Description

Embodiments of the present disclosure relate to, for example, a multi-chamber container for freezing for freezing cell-containing liquids, drugs, and the like.

As a multi-chamber container, various unstable chemicals that change over time when mixed are individually stored in each storage chamber, and when used, the partition walls between the storage chambers are opened by external force to communicate the storage chambers with each other. Therefore, a mixture of various drugs is known (see Patent Documents 1 and 2).

Recently, in the fields of reproductive medicine, regenerative medicine, etc., when the above-mentioned multi-chamber container is used, and the cell-containing liquid and each drug are individually stored in each storage chamber of the multi-chamber container and stored frozen for use ( For example, at the time of transplantation), there is an increasing need to thaw in a warm bath or the like and mix and use the cell-containing liquid and each drug by the above-mentioned method.

Japanese Patent No. 4436205 Japanese Patent No. 5118838

However, when the above-mentioned multi-chamber container is used as a freezing multi-chamber container, the following problems occur. That is, since a label indicating information on the contents stored in each storage chamber is affixed to the outside of the multi-chamber container, it gets wet with dew condensation and hot bath liquid at the time of thawing. As a result, the information displayed on the label becomes difficult to read, and the label may be damaged or peeled off in some cases.

The embodiment of the present disclosure has been made in view of the above points, and an object of the present invention is to provide a multi-chamber container for freezing that can suppress the wetting of the information display unit at the time of thawing.

The freezing double-chamber container according to one embodiment of the present disclosure is a freezing double-chamber container including a plurality of storage chambers and a partition wall that partitions each storage chamber and is provided so as to be able to communicate between the partitioned storage chambers. In the above-mentioned plurality of storage chambers, the liquid storage chamber for storing the liquid and the gas storage chamber for storing the gas are provided, and the area of the gas storage chamber on the outer surface of the double-chamber container for freezing At least, an information display unit for displaying information on the liquid stored in the liquid storage chamber is provided.

In the freezing multi-chamber container according to one embodiment of the present disclosure, the liquid storage chamber is a plurality.
It is preferable that the gas storage chamber is arranged at the end of the freezing multi-chamber container.

In the freezing multi-chamber container according to one embodiment of the present disclosure, the volume of the gas storage chamber is equal to or larger than the volume of the liquid storage chamber having the largest volume among the plurality of liquid storage chambers, or the plurality of liquids. It is preferably equal to or greater than the total volume of the storage chamber.

Further, in the freezing multi-chamber container according to one embodiment of the present disclosure, a discharge unit for discharging the liquid stored in the liquid storage chamber to the outside is further provided, and the discharge unit is provided in the gas storage chamber. It is preferable to have.

Further, in the freezing multi-chamber container according to the embodiment of the present disclosure, it is preferable that a weight portion is detachably provided on the liquid storage chamber side farthest from the gas storage chamber.

According to the present disclosure, it is possible to prevent the occurrence of dew condensation and the information display unit from being immersed in the hot bath liquid at the time of thawing, and to suppress the wetting of the information display unit.

It is a front view which shows the multi-chamber container for freezing of 1st Embodiment. It is sectional drawing which follows the XX line of FIG. It is a front view which shows the multi-chamber container for freezing of 2nd Embodiment. It is a front view which shows the multi-chamber container for freezing of 3rd Embodiment. It is sectional drawing which follows the YY line of FIG. It is a front view which shows the multi-chamber container for freezing of 4th Embodiment. It is a figure for demonstrating the calculation of the maximum volume and the appropriate volume.

Hereinafter, embodiments of the double-chamber container for freezing according to the present invention will be described with reference to the drawings. In the description of the drawings, the same elements are designated by the same reference numerals, and duplicate description will be omitted.

<First Embodiment>
FIG. 1 is a front view showing a double-chamber container for freezing according to the first embodiment, and FIG. 2 is a cross-sectional view taken along the line XX of FIG. The freezing multi-chamber container 1 of the present embodiment is a so-called soft bag, in which two rectangular transparent resin sheets having the same size are stacked, and the peripheral portions are heat-sealed (also referred to as heat welding) over four circumferences. It is formed by doing. Therefore, the sealing portion 10 is formed over the four circumferences of the freezing multi-chamber container 1. The seal portion 10 extends in the vertical direction shown in FIG. 1 and is composed of a pair of relatively long long-side seal portions 10a and a pair of short-side seal portions 10b extending in the left-right direction and relatively short. ..

Examples of the resin material used for the above-mentioned resin sheet include high-density polyethylene (HDPE) having low adsorptivity and low elution property with respect to a stored cell-containing liquid, a liquid such as a drug, and the like.
Polymethylmethacrylate (PMMA), Polycarbonate (PC), Polystyrene (P)
S), polyethylene terephthalate (PET), polyproprene (PP), polyethylene (PE), polyethylene naphthalate (PEN), cycloolefin polymer (COP)
, Cycloolefin copolymer (COC), polyacrylonitrile (PAN) and the like.

The freezing double-chamber container 1 is provided with two partition walls 11 and 12 separated from each other at predetermined intervals so as to cross the freezing double-chamber container 1. These partition walls 11 and 12 are arranged in parallel with the short side seal portion 10b, respectively, and connect the long side seal portions 10a facing each other.
The partition wall 11 and the partition wall 12 do not necessarily have to be arranged in parallel with the short side seal portion 10b, and the partition wall 11 and the partition wall 12 do not necessarily have to be parallel to each other. The internal space of the freezing multi-chamber container 1 is divided into three storage chambers by the partition walls 11 and 12, and the gas storage chamber 20 for storing gas and the first liquid for storing the first liquid are sequentially stored from the upper side to the lower side. The liquid storage chamber 21 and the second liquid storage chamber 22 for storing the second liquid are provided.

That is, the gas storage chamber 20 is arranged at the upper end of the freezing double chamber container 1, and the second liquid storage chamber 2 is arranged.
2 is arranged at the lower end of the freezing multi-chamber container 1. The first liquid storage chamber 21 is the gas storage chamber 2
It is arranged between 0 and the second liquid storage chamber 22. Here, the end is a double-chamber container for freezing 1
Means the area of the edge of. The gas storage chamber 20 and the first liquid storage chamber 21 are separated from each other by a partition wall 11, and the first liquid storage chamber 21 and the second liquid storage chamber 22 are separated from each other by a partition wall 12. Has been done.

The partition walls 11 and 12 are formed by heat sealing like the sealing portion 10, but the sealing strength thereof is weaker than that of the sealing portion 10. That is, the partition walls 11 and 12 are set to have a weak seal strength so that they can be opened more easily than the seal portion 10. Therefore, for example, the gas storage chamber 20
When you want to mix the gas stored in the first liquid and the first liquid stored in the first liquid storage chamber 21
The gas storage chamber 20 is manually pressed so as to apply pressure to the partition wall 11 from the gas storage chamber 20 side.
Since the sealing strength of the partition wall 11 is weaker than that of the sealing portion 10, the partition wall 11 is peeled off first when a predetermined pressure is exceeded. As a result, the partition wall 11 is opened, the gas storage chamber 20 and the first liquid storage chamber 21 communicate with each other, and the gas in the gas storage chamber 20 and the first liquid in the first liquid storage chamber 21 can be mixed. It will be possible. In this case, the first liquid storage chamber 21 may be pressed so as to apply pressure to the partition wall 11 from the first liquid storage chamber 21 side. Further, when it is desired to communicate the first liquid storage chamber 21 and the second liquid storage chamber 22, the partition wall 12 may be opened by the above-mentioned method. The strength of the seal is adjusted, for example, by adjusting the temperature, time, pressure, etc. at the time of sealing.

The first liquid stored in the first liquid storage chamber 21 and the second stored in the second liquid storage chamber 22.
As the liquid, in addition to the cell-containing liquid, a food-related liquid and a pharmaceutical-related liquid can be considered. Specific examples of food-related liquids include beverages and seasonings. On the other hand, as pharmaceutical-related liquids, electrolyte infusions such as physiological saline, sugar injections such as glucose, proteinaceous drugs such as blood preparations, antibiotics and antibodies, low molecular weight proteins, peptide drugs such as hormones, and nucleic acids. Drugs, cell drugs, vaccines to prevent various infectious diseases, steroids, insulin, anticancer agents, proteolytic enzyme inhibitors, analgesics, antipyretic analgesics and anti-inflammatory agents, anesthetics, fat emulsions, antihypertensive agents, vasodilators , Heparin Sodium chloride, potassium lactate and other electrolyte correction injections, vitamins, contrasting agents and the like.

The volumes of the first liquid storage chamber 21 and the second liquid storage chamber 22 may be the same or different, if necessary. On the other hand, the volume of the gas storage chamber 20 is the first liquid storage chamber 21 and the second.
Of the liquid storage chambers 22, it is preferable that the volume is equal to or larger than the volume of the liquid storage chamber having the largest volume, or equal to or larger than the total volume of the first liquid storage chamber 21 and the second liquid storage chamber 22. Here, the term "equivalent" means not only the case of equality but also the case of slightly larger or slightly smaller. Further, when the gas, the first liquid and the second liquid in the freezing double-chamber container 1 are mixed and discharged to the outside through the discharge port 33, 5% or more of the maximum volume of the freezing double-chamber container 1 is gas. It is preferably present, and more preferably 10 to 20% of the maximum volume is a gas.

The maximum volume and the appropriate volume of the gas storage chamber 20, the first liquid storage chamber 21, and the second liquid storage chamber 22 can be obtained by the following formulas that have already been well known (see FIG. 7).
Maximum volume Vmax = (0.33 × S × a)-(0.11 × a ³ )
Appropriate volume V = a / 2 × a / 2 × (ba-2) ≒ Vmax × 0.71
or,
Appropriate volume V = Vmax × 0.42
Here, a is the length of the short side and b is the length of the long side, but both may have the same length. S is the surface area (one side a × b) of each storage chamber.

Further, as shown in FIG. 1, a filling port 30 for filling gas is arranged in the gas storage chamber 20. The filling port 30 is formed in a cylindrical shape by a resin material and is attached to the long side seal portion 10a side. One end of the filling port 30 is sandwiched between the long side seal portion 10a through the long side seal portion 10a. The other end protrudes outward and its tip is sealed.

Similarly, the first liquid storage chamber 21 is provided with a filling port 31 for filling the first liquid, and the second liquid storage chamber 22 is provided with a filling port 32 for filling the second liquid. .. As shown in FIG. 1, the filling ports 30, 31, and 32 have a pair of long side seal portions 10a.
They are arranged so that they are aligned on the same side of the. By doing so, it becomes easy to perform the filling operation when filling the gas or liquid.

Further, the uppermost end of the freezing multi-chamber container 1, that is, the short side sealing portion 10b on the gas storage chamber 20 side.
A discharge port (discharge portion) 33 is further attached to the. The discharge port 33 has a structure for allowing the gas storage chamber 20, the first liquid storage chamber 21, and the second liquid storage chamber 22 to communicate with each other to mix the gas, the first liquid, and the second liquid and discharge the gas to the outside. .. Like the filling ports 30, 31, 32, the discharge port 33 is formed in a cylindrical shape by a resin material, and one end thereof is sandwiched between the short side seal portions 10b through the short side seal portion 10b. The end portion protrudes outward and is closed by the sealing lid 34.

Further, in the region of the gas storage chamber 20 on the outer surface of the freezing multi-chamber container 1, the first liquid storage chamber 21 is located.
An information display unit 35 for displaying information about the first liquid stored in the liquid and the second liquid stored in the second liquid storage chamber 22 is provided. For information on the first liquid and the second liquid,
For example, each name, ingredient, precautions when using, etc. can be mentioned.

Further, the form of the information display unit 35 may be formed by attaching a label on which characters or the like are printed to the gas storage chamber 20, or is formed by directly printing information on the gas storage chamber 20. Is also good. Further, the information display unit 35 may be a label or an IC tag printed with a QR code (registered trademark) instead of characters. In this embodiment, the information display unit 35
Is formed by attaching a label on which information is printed to the region of the gas storage chamber 20 on the outer surface of the freezing multi-chamber container 1 with an adhesive.

The area (size) of the information display unit 35 is not particularly limited as long as it does not exceed the area of the gas storage chamber 20 on the outer surface of the freezing multi-chamber container 1. For example, of the total surface area of the gas storage chamber 20, it may be attached to only one side, or it may be attached to both sides. If the area of the information display unit 35 is increased, the amount of information displayed is also increased.

The freezing double-chamber container 1 configured in this way has a gas storage chamber 20 in which gas is stored, and an information display unit 35 is provided in the area of the gas storage chamber 20 on the outer surface of the freezing double-chamber container 1. It is pasted. When thawing, the gas storage chamber 20 does not contain liquid as compared with the first liquid storage chamber 21 and the second liquid storage chamber 22, so that the temperature is likely to change and the temperature is likely to be the same as the outside air temperature. Water vapor in the outside air is less likely to condense on the outer wall of the storage chamber 20, and the risk of the information display unit 35 getting wet with dew condensation can be reduced. Further, since the gas storage chamber 20 is lifted by buoyancy during the hot bath, it is possible to prevent the information display unit 35 from being immersed in the hot bath liquid and to prevent the information display unit 35 from getting wet.

In addition, since the information display unit 35 is not attached to the first liquid storage chamber 21 and the second liquid storage chamber 22, and the freezing multi-chamber container 1 is formed of a transparent resin material, the first from the outside. The first liquid stored in the liquid storage chamber 21 and the second liquid stored in the second liquid storage chamber 22 can be visually recognized, and for example, the presence or absence of discoloration of the liquid or contamination of foreign matter can be easily confirmed from the outside. can do. Further, since the discharge port 33 and the sealing lid 34 are attached to the gas storage chamber 20, the risk of contamination caused by immersion in the hot bath liquid can be reduced.

Further, at the time of freezing and thawing of the freezing multi-chamber container 1, the gas stored in the gas storage chamber 20 was stored in the first liquid stored in the first liquid storage chamber 21 and the second liquid storage chamber 22. Since there is no mixing with the second liquid, heat is easily transferred, and the efficiency of freezing and thawing can be improved. Further, when the gas, the first liquid, and the second liquid are mixed and discharged to the outside, the gas exists in the freezing multi-chamber container 1, so that the inner surfaces of the freezing multi-chamber container 1 in contact with the gas are in contact with each other. It is possible to prevent sticking and reduce the generation of liquid residue due to sticking between the inner surfaces.

When mixing the gas, the first liquid, and the second liquid in the freezing multi-chamber container 1, the gas storage chamber 20 and the first liquid storage chamber 21 are first communicated with each other, and then the first liquid storage chamber is used. The 21 and the second liquid storage chamber 22 may be communicated with each other, or vice versa. However, the first liquid or /
When the second liquid is a liquid that easily foams, the gas storage chamber 20 is connected after the first liquid storage chamber 21 and the second liquid storage chamber 22 are communicated with each other in order to suppress the generation of foaming due to contact with the gas. And the first liquid storage chamber 21 are preferably communicated with each other.

<Second Embodiment>
FIG. 3 is a front view showing a double-chamber container for freezing according to the second embodiment. The difference between the freezing multi-chamber container 2 of the present embodiment and the first embodiment is the shape of the container. Since other configurations are the same as those of the first embodiment, duplicate description will be omitted.

Specifically, the freezing multi-chamber container 2 is formed by stacking two transparent resin sheets having a regular triangular shape having the same size and heat-sealing the peripheral edges over three sides. Therefore, the sealing portion 13 is formed over the three sides of the freezing multi-chamber container 1. Then, in the area surrounded by the seal portion 13, each seal portion 13 is formed from the position of the center of gravity in the shape of a regular triangle.
Three partition walls 14, 15 and 16 extending to the midpoint position are formed, respectively. As a result, the internal space of the double-chamber container 2 for freezing has three storage chambers (gas storage chamber 23, first liquid storage chamber 2).
4. The second liquid storage chamber 25) is evenly partitioned. The gas storage chamber 23 is arranged at one of the three ends of the freezing multi-chamber container 2. The partition walls 14, 15 and 16 have a sealing portion 13
It is formed by a heat seal in the same manner as above, but its sealing strength is weaker than that of the sealing portion 13.

A filling port 30 is attached to the gas storage chamber 23, a filling port 31 is attached to the first liquid storage chamber 24, and a filling port 32 is attached to the second liquid storage chamber 25. As shown in FIG. 3, a discharge port 33 is attached to a position corresponding to the apex of the regular triangle shape in the gas storage chamber 23, and the tip of the discharge port 33 is closed by a sealing lid 34. Further, an information display unit 35 showing information on the first liquid and the second liquid is attached to the region of the gas storage chamber 23 on the outer surface of the freezing multi-chamber container 2. The freezing multi-chamber container 2 configured in this way is the first described above.
The same action and effect as those of the embodiment can be obtained.

<Third Embodiment>
FIG. 4 is a front view showing the double-chamber container for freezing according to the third embodiment, and FIG. 5 is a cross-sectional view taken along the line YY of FIG. The difference between the freezing multi-chamber container 3 of the present embodiment and the first embodiment is the weight portion 3.
7 is to be further provided. Since other configurations are the same as those of the first embodiment, duplicate description will be omitted.

Specifically, the short side seal portion 10b on the second liquid storage chamber 22 side farthest from the gas storage chamber 20, that is, the second liquid storage chamber 22 side farthest from the gas storage chamber 20, has a bag-shaped portion. 36 are in a row. The bag-shaped portion 36 is formed, for example, by folding back one sheet member and joining both ends of the sheet member to the short side seal portion 10b. The bag-shaped portion 36 extends over the entire length of the short side sealing portion 10b, and a circular bar-shaped weight portion 37 is inserted inside the bag-shaped portion 36.

As shown in FIG. 4, since the left and right ends of the bag-shaped portion 36 are open, the weight portion 37 can be easily inserted into or removed from the inside of the bag-shaped portion 36. That is, the weight portion 37 is detachably attached to the freezing multi-chamber container 3. The weight of the weight portion 37 is set to such that the gas storage chamber 20 floats on the liquid surface (in other words, the gas storage chamber 20 does not submerge) when the freezing multi-chamber container 3 is placed in the hot bath liquid. Has been done.

The freezing multi-chamber container 3 of the present embodiment can obtain the same effects as those of the above-mentioned first embodiment, and further obtain the following effects. That is, the bag-shaped portion 36 is connected to the short side sealing portion 10b on the side of the second liquid storage chamber 22 farthest from the gas storage chamber 20, and the weight portion 37 is inserted into the bag-shaped portion 36. Therefore, for example, a hot bath liquid. When the freezing multi-chamber container 3 is thawed, the entire freezing multi-chamber container 3 can be made upright. As a result, the contact area between the first liquid storage chamber 21 and the second liquid storage chamber 22 and the hot bath liquid becomes large, so that the heat exchange rate can be increased and the thawing efficiency can be improved.

Further, by making the entire freezing multi-chamber container 3 stand upright, there is a risk that the information display unit 35 attached to the area of the gas storage chamber 20 on the outer surface of the freezing multi-chamber container 3 gets wet with the hot bath liquid, and the discharge port 33. And the risk that the sealing lid 34 is contaminated with the hot bath liquid can be further reduced. Further, since the weight portion 37 is detachably attached to the freezing multi-chamber container 3, the weight portion 37 can be easily attached to or removed as needed.

<Fourth Embodiment>
FIG. 6 is a front view showing a double-chamber container for freezing according to the fourth embodiment. The difference between the freezing multi-chamber container 4 of the present embodiment and the third embodiment is the mounting embodiment of the weight portion 38. Since other configurations are the same as those of the third embodiment, duplicate description will be omitted.

Specifically, the weight portion 38 is formed in a block shape and is integrally connected to the fastener 39 with a string or the like. A plurality of weight portions 38 are prepared, and the number of weight portions 38 to be attached to the freezing multi-chamber container 1 can be freely adjusted according to the weight and shape of the freezing multi-chamber container 1. When the weight portion 38 is attached to the freezing multi-chamber container 1, the second liquid storage chamber 22 located farthest from the gas storage chamber 20, that is, the second liquid storage chamber 22 arranged farthest from the gas storage chamber 20. This is done by sandwiching the short side seal portion 10b on the side with the fastener 39. The freezing multi-chamber container 4 of the present embodiment can obtain the same effects as those of the above-mentioned third embodiment.

Although the embodiments of the present invention have been described in detail above, the present invention is not limited to the above-described embodiments, and various designs are designed without departing from the spirit of the present invention described in the claims. You can make changes. For example, the partition wall may be formed by using a closure, a magnet, or the like, in addition to the partition wall formed by the heat seal described above. Further, the number of liquid storage chambers is not limited to the above-mentioned contents, and can be appropriately increased or decreased as needed. Further, the shape of the double-chamber container for freezing may be other polygonal or circular shape in addition to the above-mentioned contents.

Further, the weight portion 37 of the third embodiment or the weight portion 38 of the fourth embodiment is also applied to the freezing multi-chamber container 2 of the second embodiment. For example, the first liquid storage chamber 2 farthest from the gas storage chamber 23 so that the entire freezing multi-chamber container 2 stands upright while the gas storage chamber 23 is positioned upward.
Weights 37 and 38 may be attached to or removed from the seal portion 13 on the side of the fourth and the second liquid storage chamber 25.

1,2,3,4 Freezing multi-chamber container 10,13 Sealed part 11,12,14,15,16 Bulkhead 20,23 Gas storage chamber 21,24 First liquid storage chamber 22,25 Second liquid storage chamber 30 , 31, 32 Filling port 33 Discharge port (discharge part)
34 Sealing lid 35 Information display part 36 Bag-shaped part 37, 38 Weight part 39 Fastener

Claims (3)

In a multi-chamber container for freezing, which comprises a plurality of storage chambers and a partition wall that partitions each storage chamber and allows communication between the partitioned storage chambers.
The plurality of storage chambers include a liquid storage chamber in which a liquid is stored and a gas storage chamber in which only a gas is stored.
An information display unit for displaying at least information on the liquid stored in the liquid storage chamber is provided in the area of the gas storage chamber on the outer surface of the double-chamber container for freezing.
The gas storage chamber is arranged at the end of the freezing multi-chamber container so that it floats on the liquid surface when the freezing multi-chamber container is thawed with a hot bath liquid.
Further provided with a discharge unit for discharging the liquid stored in the liquid storage chamber to the outside,
The discharge unit is a multi-chamber container for freezing, which is provided in the gas storage chamber. The liquid storage chamber is one ,
The double-chamber container for freezing according to claim 1, wherein the volume of the gas storage chamber is equal to or larger than the volume of the liquid storage chamber. The liquid storage chamber is one ,
The double-chamber container for freezing according to claim 1 or 2, wherein a weight portion is detachably provided on the side of the liquid storage chamber farthest from the gas storage chamber.

Images