JP7044222B2 - 実質的にコアギュローゲンを含まないリムルスアメボサイトライセートを使用してエンドトキシンを検出する方法 - Google Patents

実質的にコアギュローゲンを含まないリムルスアメボサイトライセートを使用してエンドトキシンを検出する方法 Download PDF

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JP7044222B2
JP7044222B2 JP2019504062A JP2019504062A JP7044222B2 JP 7044222 B2 JP7044222 B2 JP 7044222B2 JP 2019504062 A JP2019504062 A JP 2019504062A JP 2019504062 A JP2019504062 A JP 2019504062A JP 7044222 B2 JP7044222 B2 JP 7044222B2
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coagulogen
endotoxin
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キャンディス スタンバー，
デイビッド， エス． ヘルプスト，
ケネス， イー． ニコルズ，
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ロンザ ウォーカーズヴィル，インコーポレーテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/50—Lipopolysaccharides; LPS

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
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  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Water Supply & Treatment (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2019504062A 2016-08-03 2017-08-02 実質的にコアギュローゲンを含まないリムルスアメボサイトライセートを使用してエンドトキシンを検出する方法 Active JP7044222B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662370493P 2016-08-03 2016-08-03
US62/370,493 2016-08-03
PCT/US2017/045137 WO2018026941A1 (en) 2016-08-03 2017-08-02 Method of detecting an endotoxin using limulus amebocyte lysate substantially free of coagulogen

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JP2019526052A JP2019526052A (ja) 2019-09-12
JP2019526052A5 JP2019526052A5 (https=) 2020-09-10
JP7044222B2 true JP7044222B2 (ja) 2022-03-30

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US (2) US11156614B2 (https=)
EP (2) EP3494226B1 (https=)
JP (1) JP7044222B2 (https=)
KR (1) KR102561368B1 (https=)
CN (1) CN109790561B (https=)
IL (1) IL264464B2 (https=)
SG (1) SG11201900767VA (https=)
WO (1) WO2018026941A1 (https=)

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US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
JP7044222B2 (ja) 2016-08-03 2022-03-30 ロンザ ウォーカーズヴィル，インコーポレーテッド 実質的にコアギュローゲンを含まないリムルスアメボサイトライセートを使用してエンドトキシンを検出する方法
CA3041517A1 (en) 2016-10-19 2018-04-26 Flodesign Sonics, Inc. Affinity cell extraction by acoustics
JP7507560B2 (ja) * 2017-01-11 2024-06-28 ロンザ ウォーカーズヴィル，インコーポレーテッド コアギュローゲンを含まない、清澄化リムルスアメボサイトライセート
WO2019118921A1 (en) 2017-12-14 2019-06-20 Flodesign Sonics, Inc. Acoustic transducer drive and controller
GB201800303D0 (en) * 2018-01-09 2018-02-21 Univ Plymouth Water quality testing

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ATE148230T1 (de) * 1989-10-30 1997-02-15 Biowhittaker Inc Kinetische bestimmungsmethode für endotoxin unter verwendung von limulus-amoebocyten-lysat und chromogenem substrat
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US5208148A (en) 1990-12-07 1993-05-04 Molecular Probes, Inc. Lipophilic fluorescent glycosidase substrates
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Toshie Harada-Suzuki et al.，Further studies on the chromogenic substrate assay method for bacterial endotoxins using horseshoe crab (Tachypleus tridentatus) hemocyte lysate，Journal of Biochemistry，1982年12月01日，92，793-800

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WO2018026941A1 (en) 2018-02-08
US11156614B2 (en) 2021-10-26
CN109790561B (zh) 2024-02-06
IL264464B1 (en) 2023-10-01
KR102561368B1 (ko) 2023-08-01
IL264464A (en) 2019-02-28
EP3494226A4 (en) 2020-03-18
US11906521B2 (en) 2024-02-20
EP3943608B1 (en) 2023-07-12
EP3494226B1 (en) 2021-09-22
CN109790561A (zh) 2019-05-21
IL264464B2 (en) 2024-02-01
US20220074940A1 (en) 2022-03-10
KR20190037284A (ko) 2019-04-05
SG11201900767VA (en) 2019-02-27
JP2019526052A (ja) 2019-09-12
US20180038864A1 (en) 2018-02-08
EP3943608C0 (en) 2023-07-12
EP3494226A1 (en) 2019-06-12
EP3943608A1 (en) 2022-01-26

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