JP7028865B2 - ５’－シクロ－ホスホン酸修飾ヌクレオチド - Google Patents

５’－シクロ－ホスホン酸修飾ヌクレオチド Download PDF

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JP7028865B2
JP7028865B2 JP2019516096A JP2019516096A JP7028865B2 JP 7028865 B2 JP7028865 B2 JP 7028865B2 JP 2019516096 A JP2019516096 A JP 2019516096A JP 2019516096 A JP2019516096 A JP 2019516096A JP 7028865 B2 JP7028865 B2 JP 7028865B2
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JP2019517588A (ja
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リー チェン
ペイ タオ
ローラー マイケル
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アローヘッド ファーマシューティカルズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
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    • C—CHEMISTRY; METALLURGY
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3233—Morpholino-type ring
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019516096A 2016-06-06 2017-06-06 ５’－シクロ－ホスホン酸修飾ヌクレオチド Active JP7028865B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022022652A JP7530927B2 (ja) 2016-06-06 2022-02-17 ５’－シクロ－ホスホン酸修飾ヌクレオチド
JP2024074835A JP2024097860A (ja) 2016-06-06 2024-05-02 ５’－シクロ－ホスホン酸修飾ヌクレオチド

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Application Number Priority Date Filing Date Title
US201662346304P 2016-06-06 2016-06-06
US62/346,304 2016-06-06
PCT/US2017/036108 WO2017214112A1 (en) 2016-06-06 2017-06-06 5'-cyclo-phosphonate modified nucleotides

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JP2022022652A Division JP7530927B2 (ja) 2016-06-06 2022-02-17 ５’－シクロ－ホスホン酸修飾ヌクレオチド

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JP2019517588A JP2019517588A (ja) 2019-06-24
JP2019517588A5 JP2019517588A5 (cg-RX-API-DMAC7.html) 2020-07-16
JP7028865B2 true JP7028865B2 (ja) 2022-03-02

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JP2019516096A Active JP7028865B2 (ja) 2016-06-06 2017-06-06 ５’－シクロ－ホスホン酸修飾ヌクレオチド
JP2022022652A Active JP7530927B2 (ja) 2016-06-06 2022-02-17 ５’－シクロ－ホスホン酸修飾ヌクレオチド
JP2024074835A Pending JP2024097860A (ja) 2016-06-06 2024-05-02 ５’－シクロ－ホスホン酸修飾ヌクレオチド

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JP2024074835A Pending JP2024097860A (ja) 2016-06-06 2024-05-02 ５’－シクロ－ホスホン酸修飾ヌクレオチド

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US (2) US11078227B2 (cg-RX-API-DMAC7.html)
EP (1) EP3464313A4 (cg-RX-API-DMAC7.html)
JP (3) JP7028865B2 (cg-RX-API-DMAC7.html)
KR (2) KR102639586B1 (cg-RX-API-DMAC7.html)
CN (2) CN109526222B (cg-RX-API-DMAC7.html)
AU (3) AU2017279512B2 (cg-RX-API-DMAC7.html)
CA (1) CA3023764A1 (cg-RX-API-DMAC7.html)
EA (1) EA201892285A1 (cg-RX-API-DMAC7.html)
IL (2) IL290633B2 (cg-RX-API-DMAC7.html)
MX (2) MX2018015109A (cg-RX-API-DMAC7.html)
TW (2) TW202423483A (cg-RX-API-DMAC7.html)
WO (1) WO2017214112A1 (cg-RX-API-DMAC7.html)

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TW202242111A (zh) 2020-12-18 2022-11-01 美商Ionis製藥公司 用於調節因子ｘｉｉ之化合物及方法
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JP2025522433A (ja) 2022-06-15 2025-07-15 アローヘッド ファーマシューティカルズ インコーポレイテッド スーパーオキシドジスムターゼ１（ＳＯＤ１）の発現を阻害するためのＲＮＡｉ剤、その組成物、及び使用の方法
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KR20250046303A (ko) 2022-08-05 2025-04-02 사네진 바이오 유에스에이 인크. 안지오텐시노겐 (agt)을 표적화하는 이중 가닥 rna 및 그의 사용 방법
CN119894915A (zh) * 2022-09-21 2025-04-25 詹森生物科技公司 新型稳定的核苷磷酸及其类似物
JP2025534701A (ja) 2022-10-14 2025-10-17 セーンジーン バイオ ユーエスエー インコーポレイティド Ｃ３を標的とする低分子干渉ｒｎａおよびその使用
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