JP7026970B2 - 白血病およびその他のがんに対する免疫療法において使用するためのペプチドおよびペプチドの組み合わせ - Google Patents

白血病およびその他のがんに対する免疫療法において使用するためのペプチドおよびペプチドの組み合わせ Download PDF

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JP7026970B2
JP7026970B2 JP2020504441A JP2020504441A JP7026970B2 JP 7026970 B2 JP7026970 B2 JP 7026970B2 JP 2020504441 A JP2020504441 A JP 2020504441A JP 2020504441 A JP2020504441 A JP 2020504441A JP 7026970 B2 JP7026970 B2 JP 7026970B2
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peptide
cells
cell
peptides
cancer
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JP2020516313A (ja
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サラ ヴァルツ，ユリアーネ
コバレフスキ，ダニエル
レッフラー，マルクス
マルコ，モレノ ディ
トラウトヴァイン，ニコ
ネルデ，アニカ
ステヴァノヴィッチ，シュテファン
ランメンゼー，ハンスーゲオルグ
ハエン，セバスチャン
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イマティクス バイオテクノロジーズ ゲーエムベーハー
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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    • C12N2310/00—Structure or type of the nucleic acid
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JP2020504441A 2017-04-10 2018-04-10 白血病およびその他のがんに対する免疫療法において使用するためのペプチドおよびペプチドの組み合わせ Expired - Fee Related JP7026970B2 (ja)

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US201762483690P 2017-04-10 2017-04-10
DE102017107710.3 2017-04-10
DE102017107710 2017-04-10
US62/483,690 2017-04-10
PCT/EP2018/059114 WO2018189152A2 (en) 2017-04-10 2018-04-10 Peptides and combination of peptides for use in immunotherapy against leukemias and other cancers

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JP2020516313A JP2020516313A (ja) 2020-06-11
JP2020516313A5 JP2020516313A5 (https=) 2021-08-05
JP7026970B2 true JP7026970B2 (ja) 2022-03-01

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US (2) US20220118016A1 (https=)
EP (1) EP3609531A2 (https=)
JP (1) JP7026970B2 (https=)
KR (1) KR20190137858A (https=)
CN (3) CN112521478A (https=)
AU (1) AU2018253341B2 (https=)
BR (1) BR112019021094A2 (https=)
CA (1) CA3059645A1 (https=)
CL (7) CL2019002878A1 (https=)
CO (1) CO2019012071A2 (https=)
CR (1) CR20190509A (https=)
IL (1) IL269813A (https=)
MA (1) MA49123A (https=)
MX (1) MX2019012226A (https=)
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CN106061488B (zh) * 2013-12-02 2021-04-09 菲奥医药公司 癌症的免疫治疗
BR112019015355A2 (pt) * 2017-01-26 2020-05-19 Sangamo Therapeutics Inc modificação genética de células b
MX2019015879A (es) * 2017-07-07 2020-02-07 Immatics Biotechnologies Gmbh Nuevos peptidos y nuevas combinacones de peptidos para el uso en la inmunoterapia contra el cancer de pulmon, incluyendo el nsclc, el sclc y otros canceres.
CN113109564A (zh) * 2021-03-15 2021-07-13 成都益安博生物技术有限公司 一种急性髓细胞性白血病的外周血tcr标志物及其检测试剂盒和应用
CN117586344B (zh) * 2022-08-12 2025-07-25 上海交通大学医学院附属瑞金医院 靶向flt3-d835突变的抗原肽及其在肿瘤免疫治疗中的应用
CN117552115B (zh) * 2024-01-12 2024-03-26 天津鲸鹏生物科技有限责任公司 用于诱导肿瘤特异性免疫响应的通用型抗原肽库及其应用

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WO2017036936A1 (en) 2015-08-28 2017-03-09 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers

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MX2019012226A (es) 2020-02-07
MA49123A (fr) 2020-03-25
PE20191617A1 (es) 2019-11-05
CL2020002948A1 (es) 2021-02-26
BR112019021094A2 (pt) 2020-05-12
CA3059645A1 (en) 2018-10-18
MY197772A (en) 2023-07-13
SG10202100324YA (en) 2021-02-25
PH12019502300A1 (en) 2020-07-06
CL2020002950A1 (es) 2021-02-26
KR20190137858A (ko) 2019-12-11
AU2018253341B2 (en) 2022-01-13
CN112521478A (zh) 2021-03-19
CL2020002951A1 (es) 2021-02-26
CL2020002952A1 (es) 2021-02-26
US20220118016A1 (en) 2022-04-21
IL269813A (en) 2019-11-28
CL2020002953A1 (es) 2021-03-12
CR20190509A (es) 2020-01-08
SG10202100326SA (en) 2021-02-25
US20220362302A1 (en) 2022-11-17
US11559550B2 (en) 2023-01-24
SG11201909058WA (en) 2019-10-30
AU2018253341A1 (en) 2019-11-14
CN111533799A (zh) 2020-08-14
CL2020002949A1 (es) 2021-02-26
JP2020516313A (ja) 2020-06-11
CO2019012071A2 (es) 2020-04-01
CN110944660A (zh) 2020-03-31
CL2019002878A1 (es) 2020-03-13
EP3609531A2 (en) 2020-02-19

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