JP7026507B2 - 眼において薬物徐放を達成する方法及び生体適合性組成物 - Google Patents
眼において薬物徐放を達成する方法及び生体適合性組成物 Download PDFInfo
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Landscapes
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| ES2900025T3 (es) * | 2014-09-06 | 2022-03-15 | Integral Biosystems Llc | Procedimientos y composiciones biocompatibles para lograr la liberación mantenida de fármaco en el ojo |
| US11458041B2 (en) * | 2015-10-08 | 2022-10-04 | Ocular Therapeutix, Inc. | Punctal plug and bioadhesives |
| EP4046609B1 (en) * | 2016-09-30 | 2025-02-26 | Mati Therapeutics Inc. | Ophthalmic drug sustained release formulation and uses thereof |
| WO2018217662A1 (en) * | 2017-05-22 | 2018-11-29 | California Institute Of Technology | Small molecule transport device with anti-condensation filler for drug delivery or waste removal |
| US20200206137A1 (en) * | 2017-07-17 | 2020-07-02 | Wolfcreek Biotech Pte Ltd | Microparticle formulations for delivery of active agents |
| IL276899B2 (en) * | 2018-03-01 | 2025-09-01 | Univ Bar Ilan | System, method and composition of materials for use in the treatment of visual disorders |
| WO2019234741A1 (en) * | 2018-06-05 | 2019-12-12 | Corneat Vision Ltd. | A synthetic ophthalmic graft patch |
| CN109853054A (zh) * | 2019-02-27 | 2019-06-07 | 上海交通大学医学院附属第九人民医院 | 一种同轴静电纺丝三维打印生物支架的装置及搭建方法 |
| EP3701974B1 (en) * | 2019-02-28 | 2024-08-28 | Agency for Science, Technology and Research | A material suitable for use as a vitreous substitute and related methods |
| JP7570342B2 (ja) | 2019-03-05 | 2024-10-21 | アエリエ ファーマシューティカルズ インコーポレイテッド | 眼の疾患又は障害を治療するための医薬組成物 |
| CN114126658A (zh) * | 2019-04-02 | 2022-03-01 | 细胞质基质有限公司 | 用于递送生物活性剂的组合物及其用途 |
| TWI826685B (zh) | 2019-05-02 | 2023-12-21 | 瑞士商愛爾康公司 | 可溶解聚合物眼睛插入物及其使用方法 |
| JP2022553408A (ja) | 2019-10-24 | 2022-12-22 | デニス・イー・ラボンバード | 眼用デバイスおよび薬物送達システムならびにそのケース |
| KR20220084381A (ko) * | 2019-12-10 | 2022-06-21 | 알콘 인코포레이티드 | 생분해성 중합체를 갖는 용해성 중합체 눈 삽입물 |
| CA3177005A1 (en) | 2020-04-27 | 2021-11-04 | Michael Goldstein | Methods of treating allergic conjunctivitis |
| KR102467288B1 (ko) * | 2020-06-09 | 2022-11-17 | 동국대학교 산학협력단 | 결막 접촉용 약물 전달기 |
| EP3928805A1 (en) * | 2020-06-26 | 2021-12-29 | Royal College of Surgeons in Ireland | A device for use in the delivery of an active agent |
| CA3199736A1 (en) * | 2020-11-23 | 2022-05-27 | Sight Sciences, Inc. | Formulations and methods for treating conditions of the eye |
| EP4346790A4 (en) * | 2021-05-26 | 2025-04-16 | The Texas A&M University System | Biodegradable mucoadhesive pharmaceutical formulations and methods thereof |
| CN114869862A (zh) * | 2022-04-24 | 2022-08-09 | 温州医科大学附属眼视光医院 | 一种带引流功能的青光眼手术缓释抗瘢痕膜及制备方法 |
| WO2025050106A1 (en) * | 2023-08-31 | 2025-03-06 | University Of Tennessee Research Foundation | Sustained release ocular implants |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090269392A1 (en) | 2008-04-29 | 2009-10-29 | Ocugenics, LLC | Drug Delivery System And Methods Of Use |
| US20090269391A1 (en) | 2008-04-29 | 2009-10-29 | Ocugenics, L.L.C. | Drug Delivery System And Methods Of Use |
| JP2013511527A (ja) | 2009-11-17 | 2013-04-04 | アーセナル メディカル, インコーポレイテッド | 薬物添加繊維 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5026559A (en) * | 1989-04-03 | 1991-06-25 | Kinaform Technology, Inc. | Sustained-release pharmaceutical preparation |
| US5177168A (en) * | 1989-10-17 | 1993-01-05 | Polymer Technology Corp. | Polymeric compositions useful in oxygen permeable contact lenses |
| WO1996011671A1 (en) * | 1994-10-12 | 1996-04-25 | Focal, Inc. | Targeted delivery via biodegradable polymers |
| US8273366B2 (en) | 2002-06-05 | 2012-09-25 | University Of Florida Research Foundation, Incorporated | Ophthalmic drug delivery system |
| CA2601864A1 (en) * | 2005-04-08 | 2006-10-19 | Surmodics, Inc. | Sustained release implants and methods for subretinal delivery of bioactive agents to treat or prevent retinal disease |
| CA2843097C (en) | 2005-05-24 | 2015-10-27 | Inspire M.D Ltd. | Stent apparatuses for treatment via body lumens and methods of use |
| US8187245B2 (en) * | 2006-09-28 | 2012-05-29 | Sca Hygiene Products Ab | Absorbent article, belt structure, manufacturing method for a belt structure and manufacturing method for an absorbent article |
| US8444970B2 (en) * | 2006-10-27 | 2013-05-21 | Lpath, Inc. | Compositions and methods for treating ocular diseases and conditions |
| JP5323720B2 (ja) * | 2006-12-18 | 2013-10-23 | アルコン リサーチ, リミテッド | 眼用薬物送達のためのデバイスおよび方法 |
| US8974814B2 (en) * | 2007-11-12 | 2015-03-10 | California Institute Of Technology | Layered drug delivery polymer monofilament fibers |
| US20100104654A1 (en) * | 2008-10-27 | 2010-04-29 | Allergan, Inc. | Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof |
| EP2396070B1 (en) | 2009-02-12 | 2024-12-04 | Incept Llc | Drug delivery through hydrogel plugs |
| US20100247606A1 (en) * | 2009-03-25 | 2010-09-30 | Allergan, Inc. | Intraocular sustained release drug delivery systems and methods for treating ocular conditions |
| CA2764862C (en) * | 2009-06-25 | 2017-08-29 | Optonol Ltd. | Fiber matrix for maintaining space in soft tissues |
| KR102337046B1 (ko) | 2010-01-22 | 2021-12-08 | 알러간, 인코포레이티드 | 전방내 서방성 치료제 이식물 |
| US20110229551A1 (en) * | 2010-03-17 | 2011-09-22 | Notus Laboratories, Inc. | Drug delivery compositions and methods using nanofiber webs |
| US9028860B2 (en) * | 2010-04-28 | 2015-05-12 | Poly-Med, Inc. | Partially microcellular, selectively hydrophilic composite construct for ocular drug delivery |
| WO2012114138A1 (fr) * | 2011-02-21 | 2012-08-30 | Cerebel-Invest Sa | Implants biodégradables pour la libération contrôlée sous-conjonctivale d'une molécule active |
| WO2012149278A1 (en) | 2011-04-29 | 2012-11-01 | Allergan, Inc. | Sustained release latanoprost implant |
| ES2912370T3 (es) | 2011-09-14 | 2022-05-25 | Forsight Vision5 Inc | Aparato para inserción ocular |
| CN203089455U (zh) * | 2013-02-01 | 2013-07-31 | 浙江大学医学院附属第二医院 | 襻上镶嵌有药物缓释微囊的人工晶状体 |
| ES2900025T3 (es) * | 2014-09-06 | 2022-03-15 | Integral Biosystems Llc | Procedimientos y composiciones biocompatibles para lograr la liberación mantenida de fármaco en el ojo |
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2017
- 2017-02-27 ZA ZA2017/01467A patent/ZA201701467B/en unknown
- 2017-08-25 ZA ZA2017/05792A patent/ZA201705792B/en unknown
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2018
- 2018-04-03 US US15/944,065 patent/US10328033B2/en active Active
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2019
- 2019-10-16 AU AU2019250153A patent/AU2019250153B2/en active Active
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090269392A1 (en) | 2008-04-29 | 2009-10-29 | Ocugenics, LLC | Drug Delivery System And Methods Of Use |
| US20090269391A1 (en) | 2008-04-29 | 2009-10-29 | Ocugenics, L.L.C. | Drug Delivery System And Methods Of Use |
| JP2013511527A (ja) | 2009-11-17 | 2013-04-04 | アーセナル メディカル, インコーポレイテッド | 薬物添加繊維 |
Non-Patent Citations (1)
| Title |
|---|
| European Journal of Pharmaceutical Sciences,2014年 3月,Vol.53,p10-16 |
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| AU2019250153B2 (en) | 2021-02-04 |
| CA2960213A1 (en) | 2016-03-10 |
| EP3188688A1 (en) | 2017-07-12 |
| AU2015311637A1 (en) | 2017-03-23 |
| US9931306B2 (en) | 2018-04-03 |
| EP3188688A4 (en) | 2018-07-25 |
| NZ729467A (en) | 2024-04-26 |
| US10328033B2 (en) | 2019-06-25 |
| ES2900025T3 (es) | 2022-03-15 |
| KR102456032B1 (ko) | 2022-10-18 |
| CA2960213C (en) | 2023-03-28 |
| EP3188688B1 (en) | 2021-11-03 |
| MY178327A (en) | 2020-10-08 |
| CN106604695B (zh) | 2018-10-23 |
| AU2019250153A1 (en) | 2019-10-31 |
| CN106604695A (zh) | 2017-04-26 |
| JP2022001582A (ja) | 2022-01-06 |
| CN109481447A (zh) | 2019-03-19 |
| ZA201701467B (en) | 2018-04-25 |
| KR20170052582A (ko) | 2017-05-12 |
| AU2015311637B2 (en) | 2019-07-18 |
| JP2017526655A (ja) | 2017-09-14 |
| SG11201701714RA (en) | 2017-04-27 |
| US20180280313A1 (en) | 2018-10-04 |
| US20170296483A1 (en) | 2017-10-19 |
| WO2016037169A1 (en) | 2016-03-10 |
| ZA201705792B (en) | 2018-12-19 |
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