JP6997623B2 - オリゴヌクレオチドを利用して細胞内の核酸を編集するための組成物および方法 - Google Patents
オリゴヌクレオチドを利用して細胞内の核酸を編集するための組成物および方法 Download PDFInfo
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- JP6997623B2 JP6997623B2 JP2017550092A JP2017550092A JP6997623B2 JP 6997623 B2 JP6997623 B2 JP 6997623B2 JP 2017550092 A JP2017550092 A JP 2017550092A JP 2017550092 A JP2017550092 A JP 2017550092A JP 6997623 B2 JP6997623 B2 JP 6997623B2
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021159689A JP2022008651A (ja) | 2014-12-12 | 2021-09-29 | オリゴヌクレオチドを利用して細胞内の核酸を編集するための組成物および方法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462091027P | 2014-12-12 | 2014-12-12 | |
| US62/091,027 | 2014-12-12 | ||
| US201562141077P | 2015-03-31 | 2015-03-31 | |
| US62/141,077 | 2015-03-31 | ||
| US201562180175P | 2015-06-16 | 2015-06-16 | |
| US62/180,175 | 2015-06-16 | ||
| US201562252693P | 2015-11-09 | 2015-11-09 | |
| US62/252,693 | 2015-11-09 | ||
| PCT/US2015/065348 WO2016094845A2 (en) | 2014-12-12 | 2015-12-11 | Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021159689A Division JP2022008651A (ja) | 2014-12-12 | 2021-09-29 | オリゴヌクレオチドを利用して細胞内の核酸を編集するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018506297A JP2018506297A (ja) | 2018-03-08 |
| JP2018506297A5 JP2018506297A5 (https=) | 2019-01-31 |
| JP6997623B2 true JP6997623B2 (ja) | 2022-02-04 |
Family
ID=56108384
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017550092A Active JP6997623B2 (ja) | 2014-12-12 | 2015-12-11 | オリゴヌクレオチドを利用して細胞内の核酸を編集するための組成物および方法 |
| JP2021159689A Pending JP2022008651A (ja) | 2014-12-12 | 2021-09-29 | オリゴヌクレオチドを利用して細胞内の核酸を編集するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021159689A Pending JP2022008651A (ja) | 2014-12-12 | 2021-09-29 | オリゴヌクレオチドを利用して細胞内の核酸を編集するための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12359197B2 (https=) |
| EP (2) | EP4372091A3 (https=) |
| JP (2) | JP6997623B2 (https=) |
| CN (1) | CN107532162A (https=) |
| CA (1) | CA2969464A1 (https=) |
| WO (1) | WO2016094845A2 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| US12359197B2 (en) * | 2014-12-12 | 2025-07-15 | Etagen Pharma, Inc. | Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides |
| EP3234134B1 (en) | 2014-12-17 | 2020-05-27 | ProQR Therapeutics II B.V. | Targeted rna editing |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| CA3022319A1 (en) * | 2016-05-06 | 2017-11-09 | Tod M. Woolf | Improved methods for genome editing with and without programmable nucleases |
| WO2017220751A1 (en) | 2016-06-22 | 2017-12-28 | Proqr Therapeutics Ii B.V. | Single-stranded rna-editing oligonucleotides |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| EP4056701A1 (en) * | 2016-08-12 | 2022-09-14 | Nexuspiral Inc. | Genome editing method |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CN110352244B (zh) | 2016-09-01 | 2023-03-21 | ProQR治疗上市公司Ⅱ | 化学修饰的编辑rna的单链寡核苷酸 |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| KR20230125856A (ko) * | 2016-12-23 | 2023-08-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Pcsk9의 유전자 편집 |
| EP3571300A1 (en) | 2017-01-19 | 2019-11-27 | ProQR Therapeutics II B.V. | Oligonucleotide complexes for use in rna editing |
| CN110612353A (zh) | 2017-03-03 | 2019-12-24 | 加利福尼亚大学董事会 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN107267516B (zh) * | 2017-07-28 | 2020-09-29 | 佛山科学技术学院 | 双sgRNA介导的基因精确修饰方法及应用 |
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| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| WO2019104094A2 (en) | 2017-11-21 | 2019-05-31 | The Regents Of The University Of California | Fusion proteins and methods for site-directed genome editing |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| WO2019136459A1 (en) | 2018-01-08 | 2019-07-11 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
| EP3737743A1 (en) | 2018-01-08 | 2020-11-18 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
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| EP3230445C0 (en) | 2024-01-24 |
| US12359197B2 (en) | 2025-07-15 |
| CN107532162A (zh) | 2018-01-02 |
| EP4372091A2 (en) | 2024-05-22 |
| CA2969464A1 (en) | 2016-06-16 |
| JP2018506297A (ja) | 2018-03-08 |
| JP2022008651A (ja) | 2022-01-13 |
| EP3230445B1 (en) | 2024-01-24 |
| WO2016094845A3 (en) | 2017-06-15 |
| EP3230445A4 (en) | 2018-09-26 |
| US20210395729A1 (en) | 2021-12-23 |
| EP3230445A2 (en) | 2017-10-18 |
| EP4372091A3 (en) | 2024-07-31 |
| WO2016094845A2 (en) | 2016-06-16 |
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