JP6987412B2 - コリンアルホスセラートを有効成分とする筋痙攣の治療、改善又は予防用の組成物及び方法 - Google Patents
コリンアルホスセラートを有効成分とする筋痙攣の治療、改善又は予防用の組成物及び方法 Download PDFInfo
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- JP6987412B2 JP6987412B2 JP2020550568A JP2020550568A JP6987412B2 JP 6987412 B2 JP6987412 B2 JP 6987412B2 JP 2020550568 A JP2020550568 A JP 2020550568A JP 2020550568 A JP2020550568 A JP 2020550568A JP 6987412 B2 JP6987412 B2 JP 6987412B2
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- muscle spasms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/316—Foods, ingredients or supplements having a functional effect on health having an effect on regeneration or building of ligaments or muscles
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Description
患者は、3ケ月間、運動によらずに安定時に筋痙攣を経験した患者を対象として選択した。患者には、筋痙攣の特徴(発生部位、発生時刻、発生頻度、痛みの強度)、筋痙攣誘発要因、筋痙攣と連関性のある疾病の保有の有無、筋痙攣と薬物服用との連関性、筋痙攣治療剤の服用などを報告するように求めた。
“トリガーポイント注射群(対照群)”の患者には、0.5%リドカイン5mlを1週間に1回トリガーポイント(4〜5箇所)に注射した。
試験期間は1ヵ月とし、前半の2週間をT1に、後半の2週間をT2に区別し、また、1週間の疼痛強度及び痙攣の頻度を測定した。疼痛強度の区分基準は、疼痛なし=0に、疼痛の程度が最も弱い=1に、疼痛の程度が最も激しい=10に決める11点のPI−NRS(pain intensity numerical rating scale)を用いて評価した。疼痛強度が2ポイント減少した時に臨床的に有意な差があるとみなされた(Farrar 2001,Rowbotham 2001,Hawker 2011)。疼痛強度は最初の訪問時に測定し、最初の薬物投与後2週目(T1)、そして4週目(T2)の疼痛強度と比較した。
“トリガーポイント注射群(対照群)”と“コリンアルホスセラート静脈内投与群(実施例1)”及び“コリンアルホスセラート経口投与群(実施例2)”の筋痙攣に対する治療効果を表4に示す。
コリンアルホスセラート 10mg
とうもろこし澱粉 100mg
ラクトース 100mg
ステアリン酸マグネシウム 2mg
コリンアルホスセラート 10mg
結晶性セルロース 3mg
ラクトース 14.8mg
ステアリン酸マグネシウム 0.2mg
コリンアルホスセラート 10mg
マンニトール 180mg
注射用滅菌蒸留水 2974mg
Na2HPO4・12H2O 26mg
コリンアルホスセラート 20mg
高果糖コーンシロップ 10g
マンニトール 5g
精製水 適量
コリンアルホスセラート 100mg
ビタミン混合物 適量
ビタミンAアセテート 70μg
ビタミンE 1.0mg
ビタミンB1 0.13mg
ビタミンB2 0.15mg
ビタミンB6 0.5mg
ビタミンB12 0.2μg
ビタミンC 10mg
ビオチン 10μg
ニコチン酸アミド 1.7mg
葉酸 50μg
パントテン酸カルシウム 0.5mg
無機質混合物 適量
硫酸第一鉄 1.75mg
酸化亜鉛 0.82mg
炭酸マグネシウム 25.3mg
第1リン酸カリウム 15mg
第2リン酸カルシウム 55mg
クエン酸カリウム 90mg
炭酸カルシウム 100mg
塩化マグネシウム 24.8mg
コリンアルホスセラート 100mg
クエン酸 1,000mg
オリゴ糖 100g
プラム濃縮物 2g
タウリン 1g
精製水を加えて 全体900mL
Claims (5)
- 有効成分としてコリンアルホスセラートを含有する、筋痙攣の治療又は予防用の医薬組成物。
- 薬学的に許容される担体をさらに含む、請求項1に記載の筋痙攣の治療又は予防用の医薬組成物。
- 静脈内投与用又は経口投与用である、請求項2に記載の筋痙攣の治療又は予防用の医薬組成物。
- 前記医薬組成物の1日当たりの投与量が、コリンアルホスセラートの量に換算して1〜400mg/体重kgである、請求項1に記載の筋痙攣の治療又は予防用の医薬組成物。
- 有効成分としてコリンアルホスセラートを含有する、筋痙攣の改善用の健康機能性食品組成物。
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KR10-2017-0169325 | 2017-12-11 | ||
KR1020170169325A KR101864384B1 (ko) | 2017-12-11 | 2017-12-11 | 콜린 알포세레이트를 유효성분으로 하는 쥐남의 치료, 개선 또는 예방용 조성물 및 방법 |
PCT/KR2018/014576 WO2019117501A1 (en) | 2017-12-11 | 2018-11-26 | Composition and method for treating, relieving or preventing muscle cramps, containing choline alfoscerate as active ingredient |
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JP2021505678A JP2021505678A (ja) | 2021-02-18 |
JP6987412B2 true JP6987412B2 (ja) | 2022-01-05 |
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US (1) | US11612611B2 (ja) |
EP (1) | EP3723766A4 (ja) |
JP (1) | JP6987412B2 (ja) |
KR (1) | KR101864384B1 (ja) |
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KR101864384B1 (ko) | 2017-12-11 | 2018-06-04 | (주)나노스템 | 콜린 알포세레이트를 유효성분으로 하는 쥐남의 치료, 개선 또는 예방용 조성물 및 방법 |
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US4424946A (en) | 1980-11-04 | 1984-01-10 | Kramer Dale C | Lightweight aircraft |
IT1199972B (it) | 1985-05-08 | 1989-01-05 | Lpb Ist Farm | Composizioni farmaceutiche per la terapia di sindromi cerebrali involutive e del decadimento mentale |
US20090176740A1 (en) | 2007-11-30 | 2009-07-09 | Phillips Ii Dauglas James | Treatment of neurological conditions by the co-administration of aniracetam and l-alpha glycerylphosphorylcholine |
KR101499533B1 (ko) * | 2008-02-15 | 2015-03-09 | 주식회사 씨티씨바이오 | 콜린 알포세레이트 함유 약학 제제 |
US9248112B2 (en) * | 2009-04-06 | 2016-02-02 | Crearene Ltd. | Hemodialysis and peritoneal dialysis solutions comprising one or more creatine compounds |
IT1402907B1 (it) | 2010-11-30 | 2013-09-27 | Ricerfarma Srl | Composizioni topiche per mantenere o ripristinare l'integrita' delle mucose. |
US20130018006A1 (en) * | 2011-07-14 | 2013-01-17 | Stephen King | Atheroscleroclastic Bioceutical Formulations |
KR102008490B1 (ko) * | 2013-01-14 | 2019-08-08 | 주식회사 바이오파마티스 | 콜린 알포세레이트 또는 이의 약학적으로 허용되는 염을 포함하는 방출 조절형 약학 조성물 및 이의 제조방법 |
KR101882224B1 (ko) * | 2015-09-02 | 2018-07-26 | 한국프라임제약주식회사 | 콜린 알포세레이트 및 메만틴을 함유하는 복합 조성물 |
KR20170094667A (ko) * | 2016-02-11 | 2017-08-21 | 양동훈 | 콜린 알포세레이트를 포함하는 비만 억제용 조성물 |
KR101864384B1 (ko) * | 2017-12-11 | 2018-06-04 | (주)나노스템 | 콜린 알포세레이트를 유효성분으로 하는 쥐남의 치료, 개선 또는 예방용 조성물 및 방법 |
KR101841654B1 (ko) * | 2017-12-19 | 2018-03-26 | (주)나노스템 | 콜린 알포세레이트를 유효성분으로 하는 신경병증성 통증의 치료, 개선 또는 예방용 조성물 및 방법 |
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JP2021505678A (ja) | 2021-02-18 |
WO2019117501A1 (en) | 2019-06-20 |
US20210169906A1 (en) | 2021-06-10 |
EP3723766A1 (en) | 2020-10-21 |
EP3723766A4 (en) | 2021-09-01 |
US11612611B2 (en) | 2023-03-28 |
KR101864384B1 (ko) | 2018-06-04 |
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