JP6987062B2 - 機能の画像データを解析するための方法及びシステム - Google Patents

機能の画像データを解析するための方法及びシステム Download PDF

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JP6987062B2
JP6987062B2 JP2018539982A JP2018539982A JP6987062B2 JP 6987062 B2 JP6987062 B2 JP 6987062B2 JP 2018539982 A JP2018539982 A JP 2018539982A JP 2018539982 A JP2018539982 A JP 2018539982A JP 6987062 B2 JP6987062 B2 JP 6987062B2
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neuron
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JP2019508109A5 (enExample
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ヒョン リー,ジン
バーナル−カサス,デイヴィッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271Specific aspects of physiological measurement analysis
    • A61B5/7275Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/242Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
    • A61B5/245Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
    • A61B5/246Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals using evoked responses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/369Electroencephalography [EEG]
    • A61B5/377Electroencephalography [EEG] using evoked responses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064Evaluating the brain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076Diagnosing or monitoring particular conditions of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/0622Optical stimulation for exciting neural tissue
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/4806Functional imaging of brain activation
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16ZINFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
    • G16Z99/00Subject matter not provided for in other main groups of this subclass
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00Medical imaging apparatus involving image processing or analysis
    • A61B2576/02Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • A61B2576/026Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the brain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/242Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
    • A61B5/245Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/369Electroencephalography [EEG]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
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  • Pathology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Molecular Biology (AREA)
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  • Neurology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Neurosurgery (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Psychology (AREA)
  • Physiology (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • General Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Signal Processing (AREA)
  • Artificial Intelligence (AREA)
  • Quality & Reliability (AREA)
  • Theoretical Computer Science (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
JP2018539982A 2016-02-01 2017-01-30 機能の画像データを解析するための方法及びシステム Active JP6987062B2 (ja)

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US201662289741P 2016-02-01 2016-02-01
US62/289,741 2016-02-01
PCT/US2017/015659 WO2017136285A1 (en) 2016-02-01 2017-01-30 Method and systems for analyzing functional imaging data

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JP6987062B2 true JP6987062B2 (ja) 2021-12-22

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EP (1) EP3410926A4 (enExample)
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KR (1) KR102855002B1 (enExample)
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Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201702600D0 (en) * 2017-02-17 2017-04-05 Biomax Informatics Ag Neurological data processing
US11420071B2 (en) 2017-04-11 2022-08-23 Peaklogic, Inc. Minimum neuronal activation threshold transcranial magnetic stimulation at personalized resonant frequency
CN111801046B (zh) 2017-11-10 2023-11-07 勒维斯公司 使用个体患者数据及治疗性脑网络图的疗效及/或治疗性参数推荐
US11227692B2 (en) * 2017-12-28 2022-01-18 International Business Machines Corporation Neuron model simulation
KR102058625B1 (ko) 2018-01-12 2019-12-23 서울대학교병원 뇌 기능 연결성 분석을 이용한 어지럼증 진단 방법 및 이를 적용하는 시스템
ES3042164T3 (en) * 2018-03-28 2025-11-18 Icahn School Med Mount Sinai Systems and methods for processing connectivity values between sub-processing regions
WO2020005525A1 (en) * 2018-06-26 2020-01-02 University Of Southern California Methods and analytical tools for the study and treatment of epileptogenesis
JP2021531891A (ja) 2018-07-30 2021-11-25 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. 機能的磁気共鳴イメージングシステム及び方法
JP6812022B2 (ja) * 2018-10-11 2021-01-13 株式会社国際電気通信基礎技術研究所 脳機能結合相関値の調整方法、脳機能結合相関値の調整システム、脳活動分類器のハーモナイズ方法、脳活動分類器のハーモナイズシステム、および脳活動バイオマーカシステム
CN109528197B (zh) * 2018-11-20 2022-07-08 中国科学院脑科学与智能技术卓越创新中心 基于脑功能图谱进行精神疾病的个体化预测方法和系统
JP7367707B2 (ja) * 2019-02-08 2023-10-24 株式会社島津製作所 脳機能計測装置
WO2020241772A1 (ja) 2019-05-31 2020-12-03 国立大学法人京都大学 情報処理装置、スクリーニング装置、情報処理方法、スクリーニング方法、及びプログラム
SG11202113100TA (en) * 2019-05-31 2021-12-30 Univ Kyoto Information processing device, screening device, information processing method, screening method, and program
US20220313144A1 (en) * 2019-09-12 2022-10-06 The General Hospital Corporation System amd method for determining treatment outcomes for neurological disorders based on functional connectivity parameters
US20220401751A1 (en) * 2019-09-25 2022-12-22 The Board Of Trustees Of The Leland Stanford Junior University Thalamic Input to Orbitofrontal Cortex Drives Brain-Wide, Frequency-Dependent Inhibition Mediated By GABA and Zona Incerta
JP7641953B2 (ja) * 2019-10-01 2025-03-07 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー マルチスケール脳ネットワーク機能のモデル化を可能にする合同の動的因果モデル化と生物物理学的モデル化
CN115023177A (zh) * 2019-12-06 2022-09-06 小利兰·斯坦福大学托管委员会 对个体海马癫痫发作进行成像以及反复癫痫发作的长期影响
US11733332B2 (en) * 2019-12-09 2023-08-22 Nous Imaging, Inc. Systems and method of precision functional mapping-guided interventional planning
US20230104356A1 (en) * 2020-03-27 2023-04-06 Tata Consultancy Services Limited Model driven sub-system for design and execution of experiments
US11037296B1 (en) 2020-08-07 2021-06-15 Omniscient Neurotechnology Pty Limited Deriving target data from selected brain data
JP2022006151A (ja) * 2020-09-01 2022-01-12 昇 松本 デジタル神経細胞情報処理装置。
US11264137B1 (en) 2020-10-08 2022-03-01 Omniscient Neurotechnology Pty Limited Centrality rankings of network graphs generated using connectomic brain data
US11264138B1 (en) * 2020-10-08 2022-03-01 Omniscient Neurotechnology Pty Limited Generating brain network impact scores
US20240075310A1 (en) * 2020-12-10 2024-03-07 Beth Israel Deaconess Medical Center, Inc. Targeting Trancranial Magnetic Stimulation to Specific Brain Regions and Evaluating the Reduction of Symptoms of Psychotic Disorders
US11699232B2 (en) * 2021-09-01 2023-07-11 Omniscient Neurotechnology Pty Limited Brain hub explorer
US20250242167A1 (en) * 2022-04-11 2025-07-31 Regents Of The University Of Minnesota Closed-loop neurostimulation using global optimization-based temporal prediction
CA3269322A1 (en) * 2022-09-30 2024-04-04 Univ Leland Stanford Junior RESOLUTION OF BRAIN CIRCUIT FUNCTION AND DYSFUNCTION WITH COMPUTER MODELING AND OPTOGENIC FUNCTIONAL MAGNETIC RESONANCE IMAGING
WO2025054159A1 (en) * 2023-09-05 2025-03-13 University Of Louisville Research Foundation, Inc. Computed-aided system for diagnosis of neurological disorders
CN118155855B (zh) * 2024-03-14 2024-09-13 武汉市精神卫生中心 基于磁共振成像观测的双相障碍神经动力学演化分析方法
CN120267969B (zh) * 2025-02-17 2025-11-25 江苏脑意科技有限公司 基于电刺激的神经调控方法、装置、设备及存储介质

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387742A (en) 1990-06-15 1995-02-07 Scios Nova Inc. Transgenic mice displaying the amyloid-forming pathology of alzheimer's disease
US5985930A (en) 1996-11-21 1999-11-16 Pasinetti; Giulio M. Treatment of neurodegenerative conditions with nimesulide
US7632679B2 (en) 2002-07-16 2009-12-15 The Trustees Of Columbia University In The City Of New York Systems and methods for screening for modulators of neural differentiation
US20040092809A1 (en) * 2002-07-26 2004-05-13 Neurion Inc. Methods for measurement and analysis of brain activity
WO2007094830A1 (en) * 2005-11-10 2007-08-23 In Silico Biosciences, Inc. Method and apparatus for computer modeling the human brain for predicting drug effects
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
US10478639B2 (en) * 2011-09-09 2019-11-19 The Regents Of The University Of California In vivo visualization and control of patholigical changes in neural circuits
WO2013142051A1 (en) 2012-03-19 2013-09-26 University Of Florida Research Foundation, Inc. Methods and systems for brain function analysis
WO2016011137A1 (en) 2014-07-15 2016-01-21 Brigham And Women's Hospital, Inc. Systems and methods for generating biomarkers based on multivariate classification of functional imaging and associated data
WO2017015395A1 (en) 2015-07-21 2017-01-26 The Board Of Trustees Of The Leland Stanford Junior University Carbon fiber optrodes for magnetic resonance imaging compatible optogenetics
WO2017040538A1 (en) 2015-08-31 2017-03-09 The Board Of Trustees Of The Leland Stanford Junior University Compressed sensing high resolution functional magnetic resonance imaging
WO2017100058A1 (en) 2015-12-09 2017-06-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for functional brain circuit analysis
US20190264285A1 (en) * 2018-02-23 2019-08-29 Northwestern University Polymorphisms for predicting treatment response to antipsychotic drugs and idenfying new drug targets

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KR20180107224A (ko) 2018-10-01
US20180368720A1 (en) 2018-12-27
US11564615B2 (en) 2023-01-31
EP3410926A4 (en) 2019-08-28
WO2017136285A1 (en) 2017-08-10
EP3410926A1 (en) 2018-12-12
JP2019508109A (ja) 2019-03-28
CA3012463A1 (en) 2017-08-10
KR102855002B1 (ko) 2025-09-04

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