JP6987050B2 - マイクロ流体装置 - Google Patents

マイクロ流体装置 Download PDF

Info

Publication number
JP6987050B2
JP6987050B2 JP2018519827A JP2018519827A JP6987050B2 JP 6987050 B2 JP6987050 B2 JP 6987050B2 JP 2018519827 A JP2018519827 A JP 2018519827A JP 2018519827 A JP2018519827 A JP 2018519827A JP 6987050 B2 JP6987050 B2 JP 6987050B2
Authority
JP
Japan
Prior art keywords
fluid
drop
conduit
liquid
drops
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018519827A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018538124A5 (https=
JP2018538124A (ja
Inventor
リチャード クック、ピーター
フォイアボルン、アレクサンダー
ウォルシュ、エドモンド
Original Assignee
オックスフォード ユニヴァーシティ イノヴェーション リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1518392.4A external-priority patent/GB201518392D0/en
Priority claimed from GBGB1614150.9A external-priority patent/GB201614150D0/en
Application filed by オックスフォード ユニヴァーシティ イノヴェーション リミテッド filed Critical オックスフォード ユニヴァーシティ イノヴェーション リミテッド
Publication of JP2018538124A publication Critical patent/JP2018538124A/ja
Publication of JP2018538124A5 publication Critical patent/JP2018538124A5/ja
Application granted granted Critical
Publication of JP6987050B2 publication Critical patent/JP6987050B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Rigid containers without fluid transport within
    • B01L3/5088Rigid containers without fluid transport within confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0673Handling of plugs of fluid surrounded by immiscible fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0694Creating chemical gradients in a fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12Specific details about manufacturing devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/089Virtual walls for guiding liquids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/16Surface properties and coatings
    • B01L2300/161Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2018519827A 2015-10-16 2016-10-14 マイクロ流体装置 Active JP6987050B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
GB1518392.4 2015-10-16
GBGB1518392.4A GB201518392D0 (en) 2015-10-16 2015-10-16 Microfluidic arrangements
GB1614157.4A GB2543619B (en) 2015-10-16 2016-08-18 A method of rehydrating a microfluidic arrangement
GBGB1614150.9A GB201614150D0 (en) 2016-08-18 2016-08-18 Microfluidic arrangements
GB1614146.7A GB2543617B (en) 2015-10-16 2016-08-18 Microfluidic arrangements
GB1614146.7 2016-08-18
GB1614150.9 2016-08-18
GB1614157.4 2016-08-18
GB1614139.2A GB2543616B (en) 2015-10-16 2016-08-18 Microfluidic arrangements
GB1614153.3 2016-08-18
GB1614139.2 2016-08-18
GB1614153.3A GB2543618B (en) 2015-10-16 2016-08-18 Microfluidic arrangements
PCT/GB2016/053204 WO2017064514A1 (en) 2015-10-16 2016-10-14 Microfluidic arrangements

Publications (3)

Publication Number Publication Date
JP2018538124A JP2018538124A (ja) 2018-12-27
JP2018538124A5 JP2018538124A5 (https=) 2019-09-12
JP6987050B2 true JP6987050B2 (ja) 2021-12-22

Family

ID=58517897

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018519827A Active JP6987050B2 (ja) 2015-10-16 2016-10-14 マイクロ流体装置

Country Status (7)

Country Link
US (1) US11590503B2 (https=)
EP (1) EP3362177A1 (https=)
JP (1) JP6987050B2 (https=)
CN (1) CN108472647B (https=)
AU (1) AU2016337312A1 (https=)
CA (1) CA3001954A1 (https=)
WO (1) WO2017064514A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018231210A1 (en) * 2017-03-07 2019-09-19 Platelet Biogenesis, Inc. Recirculating bioreactor
GB201710091D0 (en) * 2017-06-23 2017-08-09 Univ Oxford Innovation Ltd Solvo-dynamic printing
CN109387517B (zh) * 2017-08-10 2023-08-29 爱科来株式会社 分析装置和分析方法
EP3482828A1 (en) * 2017-11-08 2019-05-15 Oxford University Innovation Ltd. Methods and apparatus for adding or removing material from a microfluidic arrangement
GB2569328A (en) * 2017-12-13 2019-06-19 Univ Oxford Innovation Ltd Methods and apparatus for manufacturing a microfluidic arrangement , and a microfluidic arrangement
GB201802819D0 (en) * 2018-02-21 2018-04-04 Univ Oxford Innovation Ltd Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement
CN108483390B (zh) * 2018-03-07 2019-07-16 中国科学院化学研究所 一种功能性微纳异质结构的印刷方法
US11976269B2 (en) * 2019-03-18 2024-05-07 Cellular Research, Inc. Precise delivery of components into fluids
GB201903743D0 (en) * 2019-03-19 2019-05-01 Univ Oxford Innovation Ltd Method and system for manufacturing a microfluidic arrangement, method of manufacturing a liquid, method of performing a biological assay
CN110075934B (zh) * 2019-03-25 2021-06-01 绍兴钠钇光电有限公司 一种3d打印微流控器件及其大通量制备单分散乳液的方法
US20220260472A1 (en) * 2019-06-17 2022-08-18 Sumika Chemical Analysis Service, Ltd. Evaluation method of culture substrate and/or culture medium solution, and use of evaluation method
GB201908926D0 (en) * 2019-06-21 2019-08-07 Univ Oxford Innovation Ltd Method of manufacturing a microfluidic arrangement method of operating a microfluidic arrangement apparatus for maufacturing a microfluidic arrangment
US11717830B2 (en) 2019-06-28 2023-08-08 Wisconsin Alumni Research Foundation Open microfluidic system and various functional arrangements therefore
EP4061530B1 (en) * 2019-11-20 2025-12-10 Nuclera Ltd Spatially variable hydrophobic layers for digital microfluidics
US11999844B2 (en) * 2020-03-09 2024-06-04 Rohm And Haas Electronic Materials Llc Optically clear shear thickening fluids and optical display device comprising same
CN113213420A (zh) * 2020-07-15 2021-08-06 江苏力博医药生物技术股份有限公司 一种微阵列结构图案化的装置
CN113213419B (zh) * 2020-07-15 2023-12-08 江苏力博医药生物技术股份有限公司 一种微阵列结构图案化的工艺
EP4185407A1 (en) * 2020-07-22 2023-05-31 Sartorius Stedim Cellca GmbH Droplet microarrays
WO2022168150A1 (ja) * 2021-02-02 2022-08-11 株式会社日立ハイテク 流路デバイスおよび核酸増幅反応装置
CN114194341B (zh) * 2021-12-20 2022-11-18 杭州电子科技大学 一种水上自驱摄影机器人及其使用方法
CN116139957A (zh) * 2023-04-10 2023-05-23 电子科技大学 一种自驱动的稳定检测的微流控生物芯片及其应用
WO2024243053A1 (en) * 2023-05-19 2024-11-28 The Trustees Of The University Of Pennsylvania Fouling resistant microfluidic mixing device for robust manufacturing of nanoparticles
CN120115206B (zh) * 2025-03-19 2025-12-05 重庆大学 一种无源离散型浓度梯度芯片及无源离散型浓度梯度的建立方法
CN120479512B (zh) * 2025-07-15 2025-10-31 杭州兰格睦生物科技有限公司 基于重力捕获液滴的微流控芯片、方法及其应用

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07245467A (ja) 1994-03-07 1995-09-19 Ibiden Co Ltd プリント配線基板の製造方法
US6664044B1 (en) 1997-06-19 2003-12-16 Toyota Jidosha Kabushiki Kaisha Method for conducting PCR protected from evaporation
CN1181337C (zh) * 2000-08-08 2004-12-22 清华大学 微流体系统中实体分子的操纵方法及相关试剂盒
DE19949735A1 (de) 1999-10-15 2001-05-10 Bruker Daltonik Gmbh Prozessieren von Proben in Lösungen mit definiert kleiner Wandkontaktfläche
DE19947878C1 (de) 1999-10-05 2001-04-05 Hahn Schickard Ges Vorrichtung und Verfahren zur Qualitätskontrolle von auf ein transparentes Substrat aufgebrachten Mikrotröpfchen
US8053249B2 (en) 2001-10-19 2011-11-08 Wisconsin Alumni Research Foundation Method of pumping fluid through a microfluidic device
US7189580B2 (en) 2001-10-19 2007-03-13 Wisconsin Alumni Research Foundation Method of pumping fluid through a microfluidic device
EP2302389B1 (en) 2002-05-09 2018-01-24 The University of Chicago Device and method for pressure-driven plug transport and reaction
US6734424B2 (en) 2002-05-16 2004-05-11 Large Scale Proteomics Corporation Method for microdispensing of fluids from a pipette
US6958132B2 (en) 2002-05-31 2005-10-25 The Regents Of The University Of California Systems and methods for optical actuation of microfluidics based on opto-electrowetting
FR2842747B1 (fr) 2002-07-23 2004-10-15 Commissariat Energie Atomique Procede et dispositif pour le criblage de molecules dans des cellules
GB2395196B (en) * 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
EP1613433A2 (en) 2003-04-04 2006-01-11 Koninklijke Philips Electronics N.V. Fluid partitioning in multiple microchannels
US20050095664A1 (en) 2003-10-30 2005-05-05 Carpenter Steven E. Printing growth medium for culture and analysis of biological material
JP4698613B2 (ja) 2004-01-26 2011-06-08 プレジデント アンド フェロウズ オブ ハーバード カレッジ 流体送達のシステムおよび方法
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US20080135411A1 (en) 2004-06-16 2008-06-12 Whitehead Lorne A Microfluidic Transport By Electrostatic Deformation of Fluidic Interfaces
JP2008537063A (ja) 2005-01-31 2008-09-11 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ マイクロ流体システムのためのバルブおよび貯蔵器
US8168133B2 (en) 2005-05-09 2012-05-01 Wisconsin Alumni Research Foundation Device for performing a high throughput assay
EP1888235A1 (en) 2005-06-06 2008-02-20 Decision Biomarkers Incorporated Assays based on liquid flow over arrays
WO2007024800A2 (en) * 2005-08-22 2007-03-01 Applera Corporation Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other
US20070084706A1 (en) 2005-10-18 2007-04-19 Shuichi Takayama Microfluidic cell culture device and method for using same
EP1981624B1 (en) 2006-02-07 2011-09-07 Stokes Bio Limited A liquid bridge system and method
WO2007136328A1 (en) 2006-05-18 2007-11-29 Marilyn Rayner Manufacturing method of a membrane and a membrane thereof, for emulsification
WO2008063135A1 (en) 2006-11-24 2008-05-29 Agency For Science, Technology And Research Apparatus for processing a sample in a liquid droplet and method of using the same
WO2008079274A1 (en) * 2006-12-19 2008-07-03 University Of Chicago Spacers for microfludic channels
US8772046B2 (en) * 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
EP2140275B1 (en) 2007-05-02 2017-12-20 Siemens Healthcare Diagnostics Inc. Piezo dispensing of a diagnostic liquid into microfluidic devices
FI20075811A7 (fi) 2007-11-14 2009-05-15 Metso Paper Inc Menetelmä sakean massan syöttämiseksi muodostusalustalle ja sakeamassaperälaatikko
JP5207231B2 (ja) 2007-11-16 2013-06-12 国立大学法人 東京医科歯科大学 核酸増幅装置、方法および細胞培養・核酸増幅方法
US9296241B1 (en) 2009-12-18 2016-03-29 The United States Of America As Represented By The Secretary Of The Army Ink jet printing and patterning of explosive materials
WO2011097677A1 (en) 2010-02-12 2011-08-18 Monash University Printed multi-zone microzone plates
US9533306B2 (en) 2010-08-02 2017-01-03 The Regents Of The University Of California Single sided continuous optoelectrowetting (SCEOW) device for droplet manipulation with light patterns
AU2012236713B2 (en) 2011-03-30 2016-11-24 Bio-Rad Laboratories, Inc. Injection of multiple volumes into or out of droplets
WO2013095737A2 (en) * 2011-09-28 2013-06-27 President And Fellows Of Harvard College Systems and methods for droplet production and/or fluidic manipulation
US20150132742A1 (en) 2012-06-01 2015-05-14 President And Fellows Of Harvard College Microfluidic Devices Formed From Hydrophobic Paper
US9228104B2 (en) 2012-11-02 2016-01-05 Electronics For Imaging, Inc. Method and apparatus for controlling lightness in colored inkjet inks by means of a transparent white ink composition
JP6251475B2 (ja) 2012-12-19 2017-12-20 株式会社ミマキエンジニアリング インクジェットプリンタ及び印刷方法
US9592503B2 (en) 2013-01-25 2017-03-14 Gnubio, Inc. System and method for performing droplet inflation
AT514210B1 (de) 2013-04-25 2016-08-15 Greiner Bio-One Gmbh Dispenser-befülltes mikrofluidisches Testsystem und Verfahren dazu
TWI499779B (zh) * 2013-07-04 2015-09-11 Ind Tech Res Inst 檢測晶片及其使用方法
US10159979B2 (en) * 2013-11-11 2018-12-25 King Abdullah University Of Science And Technology Microfluidic device for high-volume production of monodisperse emulsions
CN104004652A (zh) 2014-06-16 2014-08-27 东南大学 基于单喷头喷墨打印的数字pcr液滴阵列芯片的制作方法
CN104324769B (zh) 2014-11-17 2016-06-22 中国科学院微生物研究所 基于微管道的液滴的生成方法
US20160202101A1 (en) 2015-01-12 2016-07-14 Douglas Ray Sparks Sensor structures and methods of forming using three-dimensional printing techniques
CN104941706B (zh) 2015-07-06 2016-08-17 吉林大学 一种光流微流孪生通道芯片及其制备方法
US10125342B2 (en) 2015-08-26 2018-11-13 EMULATE, Inc. Droplet fluid connections

Also Published As

Publication number Publication date
CN108472647B (zh) 2021-06-29
CA3001954A1 (en) 2017-04-20
US11590503B2 (en) 2023-02-28
WO2017064514A1 (en) 2017-04-20
AU2016337312A1 (en) 2018-05-10
US20180311671A1 (en) 2018-11-01
CN108472647A (zh) 2018-08-31
JP2018538124A (ja) 2018-12-27
EP3362177A1 (en) 2018-08-22

Similar Documents

Publication Publication Date Title
JP6987050B2 (ja) マイクロ流体装置
Zeng et al. Miniaturizing chemistry and biology using droplets in open systems
Berthier et al. The physics of microdroplets
Somaweera et al. A review of chemical gradient systems for cell analysis
CN103958050B (zh) 用于液滴产生和/或流体操纵的系统和方法
EP2621631B1 (en) Microfluidic device for production and collection of droplets of a fluid
CN104826673B (zh) 写入式二维微流控液滴阵列化装置、用途及其使用方法
CN104492508B (zh) 一种基于液体残留的超微量液滴操控装置及方法
TWI481446B (zh) 數位微流體操控裝置及操控方法
WO2016078340A1 (zh) 微量液体分配/混合装置、系统及方法
JP2005536727A5 (https=)
CN110787851A (zh) 基于压力驱动的多通道液滴定量量取装置与量取方法
Kaminski et al. Automated generation of libraries of nL droplets
GB2543619A (en) Microfluidic arrangements
US20170239661A1 (en) Apparatus, Systems and Methods for Modular Microfluidic Devices
Jin et al. Nanoliter-scale liquid metering and droplet generation based on a capillary array for high throughput screening
CN100348324C (zh) 阵列微量多通道移液器
US20230364607A1 (en) Open fluidic device for autonomous droplet generation and related methods of use for droplet formation and manipulation
CN108906144A (zh) 一种用于多种样品同步高通量加样系统
JP2006010332A (ja) 微小容量の試料溶液を形成する方法
JP2026066240A (ja) スタンプ装置、マイクロアレイ製造装置、及びマイクロアレイの製造方法
Akhtar A microsystem for on-chip droplet storage and processing
Chen Droplet-based Microfluidic Chip Design for High Throughput Screening Applications
Nahar Numerical and Experimental Study of Single Phase and Multiphase Droplet Dynamics on Electrowetting-on-Dielectrode Digital Micro-Fluidics
Ainla et al. Hydrodynamically Confined Flow Devices

Legal Events

Date Code Title Description
RD01 Notification of change of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7426

Effective date: 20181003

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20181003

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190802

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190802

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20200626

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200908

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201207

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210406

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210602

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20211102

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20211130

R150 Certificate of patent or registration of utility model

Ref document number: 6987050

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250