GB2543619B - A method of rehydrating a microfluidic arrangement - Google Patents
A method of rehydrating a microfluidic arrangement Download PDFInfo
- Publication number
- GB2543619B GB2543619B GB1614157.4A GB201614157A GB2543619B GB 2543619 B GB2543619 B GB 2543619B GB 201614157 A GB201614157 A GB 201614157A GB 2543619 B GB2543619 B GB 2543619B
- Authority
- GB
- United Kingdom
- Prior art keywords
- rehydrating
- microfluidic arrangement
- microfluidic
- arrangement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
- B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/3035—Micromixers using surface tension to mix, move or hold the fluids
- B01F33/30351—Micromixers using surface tension to mix, move or hold the fluids using hydrophilic/hydrophobic surfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/3035—Micromixers using surface tension to mix, move or hold the fluids
- B01F33/30352—Micromixers using surface tension to mix, move or hold the fluids using roughness of the surfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
- B01J2219/0065—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of liquid beads
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0694—Creating chemical gradients in a fluid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2300/08—Geometry, shape and general structure
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- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
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- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L2400/0472—Diffusion
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Priority Applications (31)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1905712.4A GB2572699B (en) | 2015-10-16 | 2016-08-18 | A method of rehydrating a microfluidic arrangement |
JP2018519827A JP6987050B2 (en) | 2015-10-16 | 2016-10-14 | Microfluidic device |
US15/768,323 US11590503B2 (en) | 2015-10-16 | 2016-10-14 | Microfluidic arrangements |
EP16784266.5A EP3362177A1 (en) | 2015-10-16 | 2016-10-14 | Microfluidic arrangements |
CN201680073970.1A CN108472647B (en) | 2015-10-16 | 2016-10-14 | Microfluidic arrangement |
AU2016337312A AU2016337312A1 (en) | 2015-10-16 | 2016-10-14 | Microfluidic arrangements |
CA3001954A CA3001954A1 (en) | 2015-10-16 | 2016-10-14 | Microfluidic arrangements |
PCT/GB2016/053204 WO2017064514A1 (en) | 2015-10-16 | 2016-10-14 | Microfluidic arrangements |
GBGB1705117.8A GB201705117D0 (en) | 2016-08-18 | 2017-03-30 | Methods and apparatus for controlling flow in a microfluid arrangement, and a microfluid arrangement |
GBGB1705118.6A GB201705118D0 (en) | 2016-08-18 | 2017-03-30 | Methods and apparatus for driving flow in a microfluid arrangement |
CA3034310A CA3034310A1 (en) | 2016-08-18 | 2017-04-18 | Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement |
AU2017313352A AU2017313352A1 (en) | 2016-08-18 | 2017-04-18 | Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement |
EP17718979.2A EP3500364A1 (en) | 2016-08-18 | 2017-04-18 | Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement |
JP2019509509A JP2019534773A (en) | 2016-08-18 | 2017-04-18 | Method and apparatus for manufacturing a microfluidic arrangement and microfluidic arrangement |
PCT/GB2017/051065 WO2018033692A1 (en) | 2016-08-18 | 2017-04-18 | Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement |
CN201780050766.2A CN109661272B (en) | 2016-08-18 | 2017-04-18 | Method and device for producing a microfluidic arrangement and microfluidic arrangement |
US16/326,129 US20190176148A1 (en) | 2016-08-18 | 2017-04-18 | Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement |
JP2019509495A JP2019528446A (en) | 2016-08-18 | 2017-08-16 | Method and apparatus for controlling flow in a microfluidic arrangement and microfluidic arrangement |
CN201780048922.1A CN109661271B (en) | 2016-08-18 | 2017-08-16 | Flow driving method and apparatus employing microfluidic arrangement |
JP2019509493A JP2019535490A (en) | 2016-08-18 | 2017-08-16 | Method and apparatus for generating flow in a microfluidic arrangement |
US16/326,134 US10967371B2 (en) | 2016-08-18 | 2017-08-16 | Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement |
AU2017313384A AU2017313384A1 (en) | 2016-08-18 | 2017-08-16 | Methods and apparatus for driving flow in a microfluidic arrangement |
CA3034290A CA3034290A1 (en) | 2016-08-18 | 2017-08-16 | Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement |
EP17755226.2A EP3500367A1 (en) | 2016-08-18 | 2017-08-16 | Methods and apparatus for driving flow in a microfluidic arrangement |
US16/326,137 US11148136B2 (en) | 2016-08-18 | 2017-08-16 | Methods and apparatus for driving flow in a microfluidic arrangement |
AU2017313382A AU2017313382A1 (en) | 2016-08-18 | 2017-08-16 | Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement |
PCT/GB2017/052420 WO2018033734A1 (en) | 2016-08-18 | 2017-08-16 | Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement |
CA3034297A CA3034297A1 (en) | 2016-08-18 | 2017-08-16 | Methods and apparatus for driving flow in a microfluidic arrangement |
CN201780048920.2A CN109641209A (en) | 2016-08-18 | 2017-08-16 | Using the flow control method and equipment and microfluid arrangement of microfluid arrangement |
EP17755225.4A EP3500366A1 (en) | 2016-08-18 | 2017-08-16 | Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement |
PCT/GB2017/052422 WO2018033736A1 (en) | 2016-08-18 | 2017-08-16 | Methods and apparatus for driving flow in a microfluidic arrangement |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1518392.4A GB201518392D0 (en) | 2015-10-16 | 2015-10-16 | Microfluidic arrangements |
Publications (3)
Publication Number | Publication Date |
---|---|
GB201614157D0 GB201614157D0 (en) | 2016-10-05 |
GB2543619A GB2543619A (en) | 2017-04-26 |
GB2543619B true GB2543619B (en) | 2020-04-08 |
Family
ID=55131190
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB1518392.4A Ceased GB201518392D0 (en) | 2015-10-16 | 2015-10-16 | Microfluidic arrangements |
GB1614139.2A Active GB2543616B (en) | 2015-10-16 | 2016-08-18 | Microfluidic arrangements |
GB1614146.7A Active GB2543617B (en) | 2015-10-16 | 2016-08-18 | Microfluidic arrangements |
GB1614157.4A Active GB2543619B (en) | 2015-10-16 | 2016-08-18 | A method of rehydrating a microfluidic arrangement |
GB1905712.4A Active GB2572699B (en) | 2015-10-16 | 2016-08-18 | A method of rehydrating a microfluidic arrangement |
GB1614153.3A Active GB2543618B (en) | 2015-10-16 | 2016-08-18 | Microfluidic arrangements |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB1518392.4A Ceased GB201518392D0 (en) | 2015-10-16 | 2015-10-16 | Microfluidic arrangements |
GB1614139.2A Active GB2543616B (en) | 2015-10-16 | 2016-08-18 | Microfluidic arrangements |
GB1614146.7A Active GB2543617B (en) | 2015-10-16 | 2016-08-18 | Microfluidic arrangements |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1905712.4A Active GB2572699B (en) | 2015-10-16 | 2016-08-18 | A method of rehydrating a microfluidic arrangement |
GB1614153.3A Active GB2543618B (en) | 2015-10-16 | 2016-08-18 | Microfluidic arrangements |
Country Status (1)
Country | Link |
---|---|
GB (6) | GB201518392D0 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201802819D0 (en) * | 2018-02-21 | 2018-04-04 | Univ Oxford Innovation Ltd | Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement |
GB201908926D0 (en) * | 2019-06-21 | 2019-08-07 | Univ Oxford Innovation Ltd | Method of manufacturing a microfluidic arrangement method of operating a microfluidic arrangement apparatus for maufacturing a microfluidic arrangment |
WO2021234703A1 (en) * | 2020-05-19 | 2021-11-25 | Technion Research & Development Foundation Limited | System and methods for fabrication of cured articles |
GB202017551D0 (en) * | 2020-11-06 | 2020-12-23 | Univ Oxford Innovation Ltd | Method of culturing cells |
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JPH07245467A (en) * | 1994-03-07 | 1995-09-19 | Ibiden Co Ltd | Manufacture of printed wiring board |
US20020176072A1 (en) * | 1999-10-05 | 2002-11-28 | Stefan Beseki | Device and method for controlling the quality of microdroplets deposited on a substrate |
US20070065946A1 (en) * | 2003-07-11 | 2007-03-22 | Commissariat Al'fnergie Atomique | Method and device for the analysis of living reaction media |
JP2009118798A (en) * | 2007-11-16 | 2009-06-04 | Tokyo Medical & Dental Univ | Apparatus and method for amplifying nucleic acid, and method of culturing cell and amplifying nucleic acid |
WO2011097677A1 (en) * | 2010-02-12 | 2011-08-18 | Monash University | Printed multi-zone microzone plates |
WO2013006312A2 (en) * | 2011-07-06 | 2013-01-10 | Advanced Liquid Logic Inc | Reagent storage on a droplet actuator |
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GB2543617A (en) | 2017-04-26 |
GB2572699A (en) | 2019-10-09 |
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GB201518392D0 (en) | 2015-12-02 |
GB2543618A (en) | 2017-04-26 |
GB2543616B (en) | 2020-04-08 |
GB2543616A (en) | 2017-04-26 |
GB201614139D0 (en) | 2016-10-05 |
GB2543619A (en) | 2017-04-26 |
GB201905712D0 (en) | 2019-06-05 |
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