GB2543619B - A method of rehydrating a microfluidic arrangement - Google Patents

A method of rehydrating a microfluidic arrangement Download PDF

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Publication number
GB2543619B
GB2543619B GB1614157.4A GB201614157A GB2543619B GB 2543619 B GB2543619 B GB 2543619B GB 201614157 A GB201614157 A GB 201614157A GB 2543619 B GB2543619 B GB 2543619B
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GB
United Kingdom
Prior art keywords
rehydrating
microfluidic arrangement
microfluidic
arrangement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1614157.4A
Other versions
GB201614157D0 (en
GB2543619A (en
Inventor
Richard Cook Peter
Feuerborn Alexander
Walsh Edmond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Priority to GB1905712.4A priority Critical patent/GB2572699B/en
Publication of GB201614157D0 publication Critical patent/GB201614157D0/en
Priority to JP2018519827A priority patent/JP6987050B2/en
Priority to US15/768,323 priority patent/US11590503B2/en
Priority to EP16784266.5A priority patent/EP3362177A1/en
Priority to CN201680073970.1A priority patent/CN108472647B/en
Priority to AU2016337312A priority patent/AU2016337312A1/en
Priority to CA3001954A priority patent/CA3001954A1/en
Priority to PCT/GB2016/053204 priority patent/WO2017064514A1/en
Priority to GBGB1705117.8A priority patent/GB201705117D0/en
Priority to GBGB1705118.6A priority patent/GB201705118D0/en
Priority to US16/326,129 priority patent/US20190176148A1/en
Priority to AU2017313352A priority patent/AU2017313352A1/en
Priority to EP17718979.2A priority patent/EP3500364A1/en
Priority to JP2019509509A priority patent/JP2019534773A/en
Priority to PCT/GB2017/051065 priority patent/WO2018033692A1/en
Priority to CN201780050766.2A priority patent/CN109661272B/en
Priority to CA3034310A priority patent/CA3034310A1/en
Publication of GB2543619A publication Critical patent/GB2543619A/en
Priority to EP17755226.2A priority patent/EP3500367A1/en
Priority to CA3034297A priority patent/CA3034297A1/en
Priority to US16/326,134 priority patent/US10967371B2/en
Priority to AU2017313384A priority patent/AU2017313384A1/en
Priority to CA3034290A priority patent/CA3034290A1/en
Priority to CN201780048922.1A priority patent/CN109661271B/en
Priority to US16/326,137 priority patent/US11148136B2/en
Priority to AU2017313382A priority patent/AU2017313382A1/en
Priority to PCT/GB2017/052420 priority patent/WO2018033734A1/en
Priority to JP2019509493A priority patent/JP2019535490A/en
Priority to CN201780048920.2A priority patent/CN109641209A/en
Priority to EP17755225.4A priority patent/EP3500366A1/en
Priority to PCT/GB2017/052422 priority patent/WO2018033736A1/en
Priority to JP2019509495A priority patent/JP2019528446A/en
Application granted granted Critical
Publication of GB2543619B publication Critical patent/GB2543619B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
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    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
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    • B01L3/5088Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01F33/302Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01F33/3035Micromixers using surface tension to mix, move or hold the fluids
    • B01F33/30351Micromixers using surface tension to mix, move or hold the fluids using hydrophilic/hydrophobic surfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
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    • B01F33/30Micromixers
    • B01F33/3035Micromixers using surface tension to mix, move or hold the fluids
    • B01F33/30352Micromixers using surface tension to mix, move or hold the fluids using roughness of the surfaces
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    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00646Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/0065Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of liquid beads
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    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2200/06Fluid handling related problems
    • B01L2200/0694Creating chemical gradients in a fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
GB1614157.4A 2015-10-16 2016-08-18 A method of rehydrating a microfluidic arrangement Active GB2543619B (en)

Priority Applications (31)

Application Number Priority Date Filing Date Title
GB1905712.4A GB2572699B (en) 2015-10-16 2016-08-18 A method of rehydrating a microfluidic arrangement
JP2018519827A JP6987050B2 (en) 2015-10-16 2016-10-14 Microfluidic device
US15/768,323 US11590503B2 (en) 2015-10-16 2016-10-14 Microfluidic arrangements
EP16784266.5A EP3362177A1 (en) 2015-10-16 2016-10-14 Microfluidic arrangements
CN201680073970.1A CN108472647B (en) 2015-10-16 2016-10-14 Microfluidic arrangement
AU2016337312A AU2016337312A1 (en) 2015-10-16 2016-10-14 Microfluidic arrangements
CA3001954A CA3001954A1 (en) 2015-10-16 2016-10-14 Microfluidic arrangements
PCT/GB2016/053204 WO2017064514A1 (en) 2015-10-16 2016-10-14 Microfluidic arrangements
GBGB1705117.8A GB201705117D0 (en) 2016-08-18 2017-03-30 Methods and apparatus for controlling flow in a microfluid arrangement, and a microfluid arrangement
GBGB1705118.6A GB201705118D0 (en) 2016-08-18 2017-03-30 Methods and apparatus for driving flow in a microfluid arrangement
CA3034310A CA3034310A1 (en) 2016-08-18 2017-04-18 Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement
AU2017313352A AU2017313352A1 (en) 2016-08-18 2017-04-18 Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement
EP17718979.2A EP3500364A1 (en) 2016-08-18 2017-04-18 Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement
JP2019509509A JP2019534773A (en) 2016-08-18 2017-04-18 Method and apparatus for manufacturing a microfluidic arrangement and microfluidic arrangement
PCT/GB2017/051065 WO2018033692A1 (en) 2016-08-18 2017-04-18 Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement
CN201780050766.2A CN109661272B (en) 2016-08-18 2017-04-18 Method and device for producing a microfluidic arrangement and microfluidic arrangement
US16/326,129 US20190176148A1 (en) 2016-08-18 2017-04-18 Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement
JP2019509495A JP2019528446A (en) 2016-08-18 2017-08-16 Method and apparatus for controlling flow in a microfluidic arrangement and microfluidic arrangement
CN201780048922.1A CN109661271B (en) 2016-08-18 2017-08-16 Flow driving method and apparatus employing microfluidic arrangement
JP2019509493A JP2019535490A (en) 2016-08-18 2017-08-16 Method and apparatus for generating flow in a microfluidic arrangement
US16/326,134 US10967371B2 (en) 2016-08-18 2017-08-16 Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement
AU2017313384A AU2017313384A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for driving flow in a microfluidic arrangement
CA3034290A CA3034290A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement
EP17755226.2A EP3500367A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for driving flow in a microfluidic arrangement
US16/326,137 US11148136B2 (en) 2016-08-18 2017-08-16 Methods and apparatus for driving flow in a microfluidic arrangement
AU2017313382A AU2017313382A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement
PCT/GB2017/052420 WO2018033734A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement
CA3034297A CA3034297A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for driving flow in a microfluidic arrangement
CN201780048920.2A CN109641209A (en) 2016-08-18 2017-08-16 Using the flow control method and equipment and microfluid arrangement of microfluid arrangement
EP17755225.4A EP3500366A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement
PCT/GB2017/052422 WO2018033736A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for driving flow in a microfluidic arrangement

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1518392.4A GB201518392D0 (en) 2015-10-16 2015-10-16 Microfluidic arrangements

Publications (3)

Publication Number Publication Date
GB201614157D0 GB201614157D0 (en) 2016-10-05
GB2543619A GB2543619A (en) 2017-04-26
GB2543619B true GB2543619B (en) 2020-04-08

Family

ID=55131190

Family Applications (6)

Application Number Title Priority Date Filing Date
GBGB1518392.4A Ceased GB201518392D0 (en) 2015-10-16 2015-10-16 Microfluidic arrangements
GB1614139.2A Active GB2543616B (en) 2015-10-16 2016-08-18 Microfluidic arrangements
GB1614146.7A Active GB2543617B (en) 2015-10-16 2016-08-18 Microfluidic arrangements
GB1614157.4A Active GB2543619B (en) 2015-10-16 2016-08-18 A method of rehydrating a microfluidic arrangement
GB1905712.4A Active GB2572699B (en) 2015-10-16 2016-08-18 A method of rehydrating a microfluidic arrangement
GB1614153.3A Active GB2543618B (en) 2015-10-16 2016-08-18 Microfluidic arrangements

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Application Number Title Priority Date Filing Date
GBGB1518392.4A Ceased GB201518392D0 (en) 2015-10-16 2015-10-16 Microfluidic arrangements
GB1614139.2A Active GB2543616B (en) 2015-10-16 2016-08-18 Microfluidic arrangements
GB1614146.7A Active GB2543617B (en) 2015-10-16 2016-08-18 Microfluidic arrangements

Family Applications After (2)

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GB1905712.4A Active GB2572699B (en) 2015-10-16 2016-08-18 A method of rehydrating a microfluidic arrangement
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