JP6974348B2 - がん処置のためのカドヘリン−１７特異的抗体及び細胞傷害性細胞 - Google Patents

がん処置のためのカドヘリン−１７特異的抗体及び細胞傷害性細胞 Download PDF

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JP6974348B2
JP6974348B2 JP2018554645A JP2018554645A JP6974348B2 JP 6974348 B2 JP6974348 B2 JP 6974348B2 JP 2018554645 A JP2018554645 A JP 2018554645A JP 2018554645 A JP2018554645 A JP 2018554645A JP 6974348 B2 JP6974348 B2 JP 6974348B2
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amino acid
acid sequence
antibody
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cdr1
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ドナルド イー． ストーントン，
ジョン ムーンチン ルク，
チジエ リー，
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Arbele Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2510/00—Genetically modified cells

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  • Gastroenterology & Hepatology (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2018554645A 2016-01-09 2017-01-07 がん処置のためのカドヘリン−１７特異的抗体及び細胞傷害性細胞 Active JP6974348B2 (ja)

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JP2021179905A JP7275232B2 (ja) 2016-01-09 2021-11-04 がん処置のためのカドヘリン－１７特異的抗体及び細胞傷害性細胞

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US201662276855P 2016-01-09 2016-01-09
US62/276,855 2016-01-09
PCT/US2017/012648 WO2017120557A1 (en) 2016-01-09 2017-01-07 Cadherin-17 specific antibodies and cytotoxic cells for cancer treatment

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JP2021179905A Active JP7275232B2 (ja) 2016-01-09 2021-11-04 がん処置のためのカドヘリン－１７特異的抗体及び細胞傷害性細胞
JP2023075948A Active JP7482287B2 (ja) 2016-01-09 2023-05-02 がん処置のためのカドヘリン－１７特異的抗体及び細胞傷害性細胞

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JP2023075948A Active JP7482287B2 (ja) 2016-01-09 2023-05-02 がん処置のためのカドヘリン－１７特異的抗体及び細胞傷害性細胞

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US (1) US11207419B2 (https=)
EP (1) EP3400013A4 (https=)
JP (3) JP6974348B2 (https=)
KR (1) KR20180127966A (https=)
CN (4) CN113817060B (https=)
AU (1) AU2017206089B2 (https=)
IL (1) IL260474B (https=)
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TWI717880B (zh) 2019-10-24 2021-02-01 中國醫藥大學附設醫院 Hla-g特異性嵌合抗原受體、核酸、hla-g特異性嵌合抗原受體表達質體、表達hla-g特異性嵌合抗原受體細胞、其用途以及用於治療癌症之醫藥組合物
JP7738914B2 (ja) * 2019-12-05 2025-09-16 アーベル リミテッド ＴｒｉＡｘ抗体の組成、その製造方法及び使用方法
EP4355778A1 (en) * 2021-06-17 2024-04-24 Boehringer Ingelheim International GmbH Novel tri-specific binding molecules
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JP2025503402A (ja) * 2021-12-07 2025-02-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｃｄｈ１７抗体及びがんを処置する方法
CN113999308B (zh) * 2021-12-30 2022-03-11 深圳市人民医院 靶向钙粘蛋白17的纳米抗体及其应用
WO2024100294A1 (en) 2022-11-11 2024-05-16 Ospedale San Raffaele S.R.L. Cdh17 car
KR20250152073A (ko) * 2023-02-23 2025-10-22 한서 바이오 엘엘씨 항체, 항원 결합 단편 및 사용 방법
WO2024220437A2 (en) * 2023-04-17 2024-10-24 Arbele Limited Compositions and methods for determining the effects of t cell engager
KR20260016950A (ko) * 2023-05-24 2026-02-04 멀티튜드 테라퓨틱스 인코퍼레이티드 항체 및 이의 항체 약물 접합체
CN121909212A (zh) * 2023-09-22 2026-04-21 乐普生物科技股份有限公司 抗cdh17抗体及其用途
CN120137019A (zh) * 2023-12-11 2025-06-13 东莞市朋志生物科技有限公司 一种抗糖化血红蛋白HbA1c的抗体及其应用
CN120230211A (zh) * 2023-12-29 2025-07-01 广东菲鹏制药股份有限公司 抗cdh17抗体或其抗原结合片段及其应用
WO2025242039A1 (zh) * 2024-05-20 2025-11-27 杭州中美华东制药有限公司 抗cdh17抗体、其抗体药物偶联物及其用途
WO2025242099A1 (zh) * 2024-05-21 2025-11-27 康诺亚生物医药科技（成都）有限公司 针对cdh17的抗体偶联药物及其用途
WO2025242100A1 (zh) * 2024-05-21 2025-11-27 康诺亚生物医药科技（成都）有限公司 针对cdh17的抗体及其用途
WO2025252211A1 (zh) * 2024-06-07 2025-12-11 映恩生物制药（苏州）有限公司 抗人cdh17抗体
WO2026015644A1 (en) * 2024-07-10 2026-01-15 The Trustees Of The University Of Pennsylvania Cadherin-17 targeting antigen biding polypeptides, chimeric antigen receptors, car-t cells and methods of treating cadherin-17 positive cancers
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AU2017206089B2 (en) 2020-04-16
AU2017206089A1 (en) 2018-08-30
IL260474B (en) 2020-08-31
CN113817059B (zh) 2024-03-08
CN113817060A (zh) 2021-12-21
CN113912725A (zh) 2022-01-11
CN108778327B (zh) 2021-11-05
KR20180127966A (ko) 2018-11-30
CN113817060B (zh) 2024-03-08
US11207419B2 (en) 2021-12-28
JP7275232B2 (ja) 2023-05-17
CN113817059A (zh) 2021-12-21
JP2019518721A (ja) 2019-07-04
JP2022036939A (ja) 2022-03-08
US20190046655A1 (en) 2019-02-14
WO2017120557A1 (en) 2017-07-13
CN113912725B (zh) 2024-03-08
JP7482287B2 (ja) 2024-05-13
EP3400013A1 (en) 2018-11-14
CN108778327A (zh) 2018-11-09
EP3400013A4 (en) 2019-09-11
JP2023109790A (ja) 2023-08-08

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