JP6952706B2 - エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 - Google Patents

エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 Download PDF

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JP6952706B2
JP6952706B2 JP2018546669A JP2018546669A JP6952706B2 JP 6952706 B2 JP6952706 B2 JP 6952706B2 JP 2018546669 A JP2018546669 A JP 2018546669A JP 2018546669 A JP2018546669 A JP 2018546669A JP 6952706 B2 JP6952706 B2 JP 6952706B2
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antibody
epitope
epitope tag
seq
tag
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JP2019512224A (ja
JP2019512224A5 (https=
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マイケル ファレル，
マイケル ファレル，
エリック メイ，
エリック メイ，
レイ タン，
レイ タン，
ウェンチュン チャン，
ウェンチュン チャン，
アントニー ハバード，
アントニー ハバード，
ツー−シュエン ツァオ，
ツー−シュエン ツァオ，
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ヴェンタナ メディカル システムズ， インク．
ヴェンタナ メディカル システムズ， インク．
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2018546669A 2016-03-08 2017-03-07 エピトープタグを有する組換え抗体を使用する多重化免疫組織化学 Active JP6952706B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021156935A JP7174126B2 (ja) 2016-03-08 2021-09-27 エピトープタグを有する組換え抗体を使用する多重化免疫組織化学
JP2022177332A JP2023024990A (ja) 2016-03-08 2022-11-04 エピトープタグを有する組換え抗体を使用する多重化免疫組織化学

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662305440P 2016-03-08 2016-03-08
US62/305,440 2016-03-08
US201662418667P 2016-11-07 2016-11-07
US62/418,667 2016-11-07
US201762461651P 2017-02-21 2017-02-21
US62/461,651 2017-02-21
PCT/US2017/021157 WO2017155996A1 (en) 2016-03-08 2017-03-07 Multiplexed immunohistochemistry using recombinant antibodies with epitope tags

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JP2021156935A Division JP7174126B2 (ja) 2016-03-08 2021-09-27 エピトープタグを有する組換え抗体を使用する多重化免疫組織化学

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JP2019512224A JP2019512224A (ja) 2019-05-16
JP2019512224A5 JP2019512224A5 (https=) 2020-04-16
JP6952706B2 true JP6952706B2 (ja) 2021-10-20

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JP2018546669A Active JP6952706B2 (ja) 2016-03-08 2017-03-07 エピトープタグを有する組換え抗体を使用する多重化免疫組織化学
JP2021156935A Active JP7174126B2 (ja) 2016-03-08 2021-09-27 エピトープタグを有する組換え抗体を使用する多重化免疫組織化学
JP2022177332A Pending JP2023024990A (ja) 2016-03-08 2022-11-04 エピトープタグを有する組換え抗体を使用する多重化免疫組織化学

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JP2022177332A Pending JP2023024990A (ja) 2016-03-08 2022-11-04 エピトープタグを有する組換え抗体を使用する多重化免疫組織化学

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US (3) US11112413B2 (https=)
EP (1) EP3426684B1 (https=)
JP (3) JP6952706B2 (https=)
AU (1) AU2017229370B2 (https=)
WO (1) WO2017155996A1 (https=)

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KR20180083868A (ko) 2015-10-30 2018-07-23 알레타 바이오쎄라퓨틱스, 인크. 종양 형질도입용 조성물 및 방법
JP7115982B2 (ja) 2015-10-30 2022-08-09 アレタ・バイオセラピューティクス・インコーポレイテッド 癌の治療のための組成物及び方法
AU2017229370B2 (en) * 2016-03-08 2021-03-11 Ventana Medical Systems, Inc. Multiplexed immunohistochemistry using recombinant antibodies with epitope tags
US20210188953A1 (en) * 2017-11-07 2021-06-24 Trustees Of Tufts College Heteromultimeric binding molecules for toxin neutralization, compositions and methods thereof
EP3946737B1 (en) * 2019-04-03 2025-06-04 Access Medical Systems, Ltd. Method for re-using hapten-coated probe in an immunoassay
CN110850094A (zh) * 2019-11-22 2020-02-28 西安交通大学 一种免疫组化双标单染试剂盒及其使用方法和应用
CN114113616B (zh) * 2021-12-07 2022-08-23 深圳裕策生物科技有限公司 一种试剂盒及其染色方法
WO2023162042A1 (ja) 2022-02-22 2023-08-31 日本電信電話株式会社 センサー付きハイドロゲル流路型デバイス
JP2025532064A (ja) 2022-09-22 2025-09-29 アジレント・テクノロジーズ・インク 免疫組織化学（ｉｈｃ）プロトコールにおける使用のためおよびがんを診断するための抗ヒトｉｃｏｓ抗体

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US20240230667A1 (en) 2024-07-11
US20220057408A1 (en) 2022-02-24
JP2019512224A (ja) 2019-05-16
EP3426684B1 (en) 2024-10-09
JP2023024990A (ja) 2023-02-21
WO2017155996A1 (en) 2017-09-14
JP7174126B2 (ja) 2022-11-17
AU2017229370A1 (en) 2018-08-16
US11112413B2 (en) 2021-09-07
US20190094242A1 (en) 2019-03-28
EP3426684A1 (en) 2019-01-16
JP2022003064A (ja) 2022-01-11
US11988673B2 (en) 2024-05-21
AU2017229370B2 (en) 2021-03-11
CA3016555A1 (en) 2017-09-14

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