JP6948331B2 - Ｇｄｆ１１での処置は、体重増加を防止し、耐糖能を改善し、そして脂肪肝を低減する - Google Patents

Ｇｄｆ１１での処置は、体重増加を防止し、耐糖能を改善し、そして脂肪肝を低減する Download PDF

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JP6948331B2
JP6948331B2 JP2018535388A JP2018535388A JP6948331B2 JP 6948331 B2 JP6948331 B2 JP 6948331B2 JP 2018535388 A JP2018535388 A JP 2018535388A JP 2018535388 A JP2018535388 A JP 2018535388A JP 6948331 B2 JP6948331 B2 JP 6948331B2
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gdf11
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composition
polypeptide
composition according
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JP2019501925A (ja
JP2019501925A5 (enExample
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オルネラ バランドン，
オルネラ バランドン，
トマッソ ポッジョーリ，
トマッソ ポッジョーリ，
ダグラス エー． メルトン，
ダグラス エー． メルトン，
リチャード ティー． リー，
リチャード ティー． リー，
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Brigham and Womens Hospital Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
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    • A61K38/18—Growth factors; Growth regulators
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2018535388A 2016-01-06 2017-01-06 Ｇｄｆ１１での処置は、体重増加を防止し、耐糖能を改善し、そして脂肪肝を低減する Active JP6948331B2 (ja)

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JP2021126586A JP7288012B2 (ja) 2016-01-06 2021-08-02 Ｇｄｆ１１での処置は、体重増加を防止し、耐糖能を改善し、そして脂肪肝を低減する
JP2022193543A JP2023014339A (ja) 2016-01-06 2022-12-02 Ｇｄｆ１１での処置は、体重増加を防止し、耐糖能を改善し、そして脂肪肝を低減する

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US201662275645P 2016-01-06 2016-01-06
US62/275,645 2016-01-06
PCT/US2017/012505 WO2017120450A1 (en) 2016-01-06 2017-01-06 Treatment with gdf11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis

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JP2021126586A Division JP7288012B2 (ja) 2016-01-06 2021-08-02 Ｇｄｆ１１での処置は、体重増加を防止し、耐糖能を改善し、そして脂肪肝を低減する

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JP2019501925A JP2019501925A (ja) 2019-01-24
JP2019501925A5 JP2019501925A5 (enExample) 2020-02-13
JP6948331B2 true JP6948331B2 (ja) 2021-10-13

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JP2021126586A Active JP7288012B2 (ja) 2016-01-06 2021-08-02 Ｇｄｆ１１での処置は、体重増加を防止し、耐糖能を改善し、そして脂肪肝を低減する
JP2022193543A Pending JP2023014339A (ja) 2016-01-06 2022-12-02 Ｇｄｆ１１での処置は、体重増加を防止し、耐糖能を改善し、そして脂肪肝を低減する

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JP2022193543A Pending JP2023014339A (ja) 2016-01-06 2022-12-02 Ｇｄｆ１１での処置は、体重増加を防止し、耐糖能を改善し、そして脂肪肝を低減する

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US (2) US10980857B2 (enExample)
EP (2) EP3399998B1 (enExample)
JP (3) JP6948331B2 (enExample)
CN (2) CN109310742B (enExample)
CA (1) CA3010799A1 (enExample)
ES (1) ES2893813T3 (enExample)
IL (4) IL301476A (enExample)
WO (1) WO2017120450A1 (enExample)

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CN109310742A (zh) 2019-02-05
ES2893813T3 (es) 2022-02-10
IL293766A (en) 2022-08-01
WO2017120450A1 (en) 2017-07-13
IL293766B2 (en) 2023-08-01
EP3399998B1 (en) 2021-07-21
JP2021169533A (ja) 2021-10-28
IL293766B1 (en) 2023-04-01
CN116059320A (zh) 2023-05-05
IL260468B (en) 2021-08-31
HK1257377A1 (en) 2019-10-18
CN109310742B (zh) 2022-12-02
US20190015479A1 (en) 2019-01-17
JP2023014339A (ja) 2023-01-26
EP3399998A1 (en) 2018-11-14
IL301476A (en) 2023-05-01
JP7288012B2 (ja) 2023-06-06
CA3010799A1 (en) 2017-07-13
JP2019501925A (ja) 2019-01-24
US10980857B2 (en) 2021-04-20
IL285371A (en) 2021-09-30
EP3399998A4 (en) 2019-11-06
US11890321B2 (en) 2024-02-06
IL285371B (en) 2022-07-01
US20210308221A1 (en) 2021-10-07
EP3949979A1 (en) 2022-02-09

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