JP6944720B2 - リジン−尿素−グルタメートファーマコフォアを含む修飾デキストラン複合体 - Google Patents

リジン−尿素−グルタメートファーマコフォアを含む修飾デキストラン複合体 Download PDF

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JP6944720B2
JP6944720B2 JP2018566546A JP2018566546A JP6944720B2 JP 6944720 B2 JP6944720 B2 JP 6944720B2 JP 2018566546 A JP2018566546 A JP 2018566546A JP 2018566546 A JP2018566546 A JP 2018566546A JP 6944720 B2 JP6944720 B2 JP 6944720B2
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complex
dextran
modified dextran
modified
complex according
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JP2019527740A5 (OSRAM
JP2019527740A (ja
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アール ホルンバーグ、アンダース
アール ホルンバーグ、アンダース
ニルソン、ステン
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デクステック メディカル エービー
デクステック メディカル エービー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
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    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121—Solutions, i.e. homogeneous liquid formulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran

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  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
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  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018566546A 2016-06-22 2017-06-19 リジン−尿素−グルタメートファーマコフォアを含む修飾デキストラン複合体 Active JP6944720B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20165515A FI127538B (en) 2016-06-22 2016-06-22 MODIFIED Dextran Conjugates
FI20165515 2016-06-22
PCT/EP2017/064929 WO2017220488A1 (en) 2016-06-22 2017-06-19 Modified dextran conjugates comprising a lysine-urea-glutamate pharmacophore

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JP2019527740A JP2019527740A (ja) 2019-10-03
JP2019527740A5 JP2019527740A5 (OSRAM) 2020-05-21
JP6944720B2 true JP6944720B2 (ja) 2021-10-06

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US (1) US20190175767A1 (OSRAM)
EP (1) EP3475311B1 (OSRAM)
JP (1) JP6944720B2 (OSRAM)
CN (1) CN109312004A (OSRAM)
AU (1) AU2017283151A1 (OSRAM)
CA (1) CA3027920C (OSRAM)
FI (1) FI127538B (OSRAM)
IL (1) IL263886B2 (OSRAM)
WO (1) WO2017220488A1 (OSRAM)

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PL240772B1 (pl) * 2018-06-11 2022-06-06 Nanothea Spolka Akcyjna Sposób wytwarzania nanocząstek polimerowych chelatujących izotopy promieniotwórcze do zastosowania w diagnostyce i terapii
EP3636635A1 (en) 2018-10-11 2020-04-15 Academisch Ziekenhuis Leiden h.o.d.n. LUMC Imaging agents
CN113747927B (zh) * 2019-02-14 2024-10-18 德国癌症研究中心 包含淀粉酶可切割接头的前列腺特异性膜抗原(psma)配体
US20220152231A1 (en) * 2019-03-19 2022-05-19 Nanothea S.A. Process of preparing polymeric nanoparticles that chelate radioactive isotopes and have a surface modified with specific molecules targeting the psma receptor and their use
CN112209970B (zh) * 2020-10-21 2021-10-29 北京师范大学 一种锝-99m标记含异腈的谷氨酸-脲衍生物的制备方法和应用
CN121002057A (zh) * 2023-03-30 2025-11-21 启德医药科技（苏州）有限公司 二糖接头、含有该二糖接头的接头-有效载荷以及聚糖链重构的抗体-药物偶联物及其制备方法和用途

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US4822594A (en) * 1987-01-27 1989-04-18 Gibby Wendell A Contrast enhancing agents for magnetic resonance images
SE9803482D0 (sv) 1998-10-13 1998-10-13 Anders Holmberg Ion exchange tumor targeting (IETT)
DK2097111T3 (en) * 2006-11-08 2015-08-24 Molecular Insight Pharm Inc Heterodimers of glutamic acid
FI119513B (fi) * 2007-03-07 2008-12-15 Dextech Medical Ab Muokatut hydroksipolymeerikonjugaatit, joilla on tappava vaikutus tuumorisoluihin
JP5680409B2 (ja) * 2007-06-26 2015-03-04 ザ ジョンズ ホプキンス ユニバーシティ 前立腺特異膜抗原（ｐｓｍａ）の標識阻害剤、生物学的評価およびイメージング剤としての使用
WO2009124580A1 (en) * 2008-04-07 2009-10-15 Dextech Medical Ab Modified hydroxypolymer conjugates with bone seeking and tumor killing moieties
ES2732060T3 (es) * 2011-08-05 2019-11-20 Molecular Insight Pharm Inc Inhibidores radiomarcados del antígeno de membrana específico de la próstata
CN113149921B (zh) * 2011-11-30 2024-11-29 约翰霍普金斯大学 前列腺特异性膜抗原(psma)的同源多价抑制剂和异源多价抑制剂以及其用途
US9636413B2 (en) * 2012-11-15 2017-05-02 Endocyte, Inc. Conjugates for treating diseases caused by PSMA expressing cells
EP2958596B1 (en) * 2013-02-15 2019-12-04 Case Western Reserve University Psma ligands and uses thereof
US20150110716A1 (en) * 2013-10-18 2015-04-23 Molecular Insight Pharmaceuticals, Inc. Methods of using spect/ct analysis for staging cancer
CN111285918B (zh) * 2014-05-06 2024-05-31 约翰霍普金斯大学 用于psma靶向的成像和放射疗法的金属/放射性金属标记的psma抑制物
EP3011976A1 (en) * 2014-10-20 2016-04-27 Deutsches Krebsforschungszentrum 18F-tagged inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents

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IL263886A (en) 2019-01-31
EP3475311B1 (en) 2020-05-13
WO2017220488A1 (en) 2017-12-28
FI20165515A7 (fi) 2017-12-23
AU2017283151A1 (en) 2018-12-06
IL263886B1 (en) 2023-05-01
EP3475311A1 (en) 2019-05-01
IL263886B2 (en) 2023-09-01
CA3027920A1 (en) 2017-12-28
US20190175767A1 (en) 2019-06-13
CN109312004A (zh) 2019-02-05
CA3027920C (en) 2023-10-17
JP2019527740A (ja) 2019-10-03
FI127538B (en) 2018-08-31

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