JP6942054B2 - ミオスタチンにおけるアンチセンスに誘導されるエクソンの排除 - Google Patents

ミオスタチンにおけるアンチセンスに誘導されるエクソンの排除 Download PDF

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JP6942054B2
JP6942054B2 JP2017548452A JP2017548452A JP6942054B2 JP 6942054 B2 JP6942054 B2 JP 6942054B2 JP 2017548452 A JP2017548452 A JP 2017548452A JP 2017548452 A JP2017548452 A JP 2017548452A JP 6942054 B2 JP6942054 B2 JP 6942054B2
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formula
alkyl
intron
exon
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フレデリック ジョセフ シュネル，
フレデリック ジョセフ シュネル，
リチャード キース ベストウィック，
リチャード キース ベストウィック，
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サレプタ セラピューティクス，インコーポレイテッド
サレプタ セラピューティクス，インコーポレイテッド
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
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    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/314—Phosphoramidates
    • C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3233—Morpholino-type ring
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3513—Protein; Peptide
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/33—Alteration of splicing

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  • Chemical & Material Sciences (AREA)
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  • Molecular Biology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP2017548452A 2015-03-18 2016-03-18 ミオスタチンにおけるアンチセンスに誘導されるエクソンの排除 Active JP6942054B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562135048P 2015-03-18 2015-03-18
US62/135,048 2015-03-18
US201562162571P 2015-05-15 2015-05-15
US62/162,571 2015-05-15
PCT/US2016/023239 WO2016149659A2 (en) 2015-03-18 2016-03-18 Antisense-induced exon exclusion in myostatin

Related Child Applications (1)

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JP2021037024A Division JP2021090458A (ja) 2015-03-18 2021-03-09 ミオスタチンにおけるアンチセンスに誘導されるエクソンの排除

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JP2018518148A JP2018518148A (ja) 2018-07-12
JP6942054B2 true JP6942054B2 (ja) 2021-09-29

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JP2017548452A Active JP6942054B2 (ja) 2015-03-18 2016-03-18 ミオスタチンにおけるアンチセンスに誘導されるエクソンの排除
JP2021037024A Pending JP2021090458A (ja) 2015-03-18 2021-03-09 ミオスタチンにおけるアンチセンスに誘導されるエクソンの排除

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US (2) US11015200B2 (https=)
EP (1) EP3271372A4 (https=)
JP (2) JP6942054B2 (https=)
BR (1) BR112017019971A2 (https=)
MA (1) MA41795A (https=)
WO (1) WO2016149659A2 (https=)

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EP1855694B1 (en) 2005-02-09 2020-12-02 Sarepta Therapeutics, Inc. Antisense composition for treating muscle atrophy
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MA41795A (fr) 2015-03-18 2018-01-23 Sarepta Therapeutics Inc Exclusion d'un exon induite par des composés antisens dans la myostatine
US10563199B2 (en) * 2015-09-16 2020-02-18 Nippon Shinyaku Co., Ltd. Antisense nucleic acid for treating amyotrophy
AU2017385962B2 (en) * 2016-12-30 2021-09-02 Olipass Corporation Exon skipping by peptide nucleic acid derivatives
WO2020072125A1 (en) * 2018-10-03 2020-04-09 Massachusetts Institute Of Technology Splicing-dependent transcriptional gene silencing or activation
CN114728999A (zh) * 2019-09-05 2022-07-08 赛诺菲 含有核苷酸类似物的寡核苷酸
GB2636643B (en) * 2020-12-03 2026-03-11 Lart Bio Co Ltd Transgenic animal having modified myostatin gene
CA3211057A1 (en) * 2021-02-26 2022-09-01 Knc Laboratories Co., Ltd. Nucleic acid medicine expressing splicing variant of myostatin

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