JP6924211B2 - 炎症を処置するための化合物および方法 - Google Patents

炎症を処置するための化合物および方法 Download PDF

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JP6924211B2
JP6924211B2 JP2018557295A JP2018557295A JP6924211B2 JP 6924211 B2 JP6924211 B2 JP 6924211B2 JP 2018557295 A JP2018557295 A JP 2018557295A JP 2018557295 A JP2018557295 A JP 2018557295A JP 6924211 B2 JP6924211 B2 JP 6924211B2
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acid
chemerin
composition
lipid
use according
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Japanese (ja)
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JP2019507182A5 (https=
JP2019507182A (ja
Inventor
チャールズ コーエン，
チャールズ コーエン，
クリシュナ クマール，
クリシュナ クマール，
アラン エス． コピン，
アラン エス． コピン，
ベンジャミン エヌ． ハーウッド，
ベンジャミン エヌ． ハーウッド，
ベンカタ エス． ラマン，
ベンカタ エス． ラマン，
ペドラム ハムラー，
ペドラム ハムラー，
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Tufts Medical Center Inc
Tufts University
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Tufts Medical Center Inc
Tufts University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2018557295A 2016-01-22 2017-01-23 炎症を処置するための化合物および方法 Active JP6924211B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021125537A JP2021169531A (ja) 2016-01-22 2021-07-30 炎症を処置するための化合物および方法
JP2023029552A JP7432028B2 (ja) 2016-01-22 2023-02-28 炎症を処置するための化合物および方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662286070P 2016-01-22 2016-01-22
US62/286,070 2016-01-22
PCT/US2017/014605 WO2017127827A1 (en) 2016-01-22 2017-01-23 Compounds and methods for treating inflammation

Related Child Applications (1)

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JP2021125537A Division JP2021169531A (ja) 2016-01-22 2021-07-30 炎症を処置するための化合物および方法

Publications (3)

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JP2019507182A JP2019507182A (ja) 2019-03-14
JP2019507182A5 JP2019507182A5 (https=) 2020-03-05
JP6924211B2 true JP6924211B2 (ja) 2021-08-25

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JP2018557295A Active JP6924211B2 (ja) 2016-01-22 2017-01-23 炎症を処置するための化合物および方法
JP2021125537A Pending JP2021169531A (ja) 2016-01-22 2021-07-30 炎症を処置するための化合物および方法
JP2023029552A Active JP7432028B2 (ja) 2016-01-22 2023-02-28 炎症を処置するための化合物および方法

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JP2021125537A Pending JP2021169531A (ja) 2016-01-22 2021-07-30 炎症を処置するための化合物および方法
JP2023029552A Active JP7432028B2 (ja) 2016-01-22 2023-02-28 炎症を処置するための化合物および方法

Country Status (7)

Country Link
US (3) US11197906B2 (https=)
EP (1) EP3405208B1 (https=)
JP (3) JP6924211B2 (https=)
AU (1) AU2017210118B2 (https=)
CA (1) CA3012190A1 (https=)
ES (1) ES2805037T3 (https=)
WO (1) WO2017127827A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014168721A2 (en) 2013-04-12 2014-10-16 Tufts Medical Center Methods and systems for designing and/or characterizing soluble lipidated ligand agents
EP3405208B1 (en) 2016-01-22 2020-04-29 Tufts Medical Center, Inc. Compounds and methods for treating inflammation
JP7251036B2 (ja) * 2018-06-28 2023-04-04 ポーラ化成工業株式会社 皮膚老化改善剤のスクリーニング方法
US12559523B2 (en) 2019-08-01 2026-02-24 Okyo Pharma Limited Compositions comprising chemerin analogs and methods of use
EP4522118A2 (en) * 2022-05-12 2025-03-19 Okyo Pharma Limited Chemerin-containing formulation for treating dry eye disease

Family Cites Families (20)

* Cited by examiner, † Cited by third party
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US6416738B1 (en) 1973-12-07 2002-07-09 Neorx Corporation Pretargeting methods and compounds
US5200473A (en) 1988-03-25 1993-04-06 Jeanneret Gris Gilbert Chelating resins and method for their use in the extraction of metal ions
JP3507486B2 (ja) 1991-03-15 2004-03-15 アムジエン・インコーポレーテツド 顆粒球コロニー刺激因子の肺内投与
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
CN1355690A (zh) 1999-04-16 2002-06-26 奥赛尔股份有限公司 一种延长可溶性病毒特异性配体在粘膜上半寿期的方法
IL160142A0 (en) 2001-08-17 2004-06-20 Anosys Inc Methods and compounds for the targeting of protein to exosomes
US7169892B2 (en) 2003-01-10 2007-01-30 Astellas Pharma Inc. Lipid-peptide-polymer conjugates for long blood circulation and tumor specific drug delivery systems
WO2004084950A2 (en) 2003-03-24 2004-10-07 Case Western Reserve University Cell targeting methods and compositions
WO2005121755A1 (en) 2004-06-14 2005-12-22 Commonwealth Scientific And Industrial Research Organisation Cell free g-protein coupled receptor and ligand assay
MX2007004676A (es) 2004-10-27 2007-11-14 Univ Denver Analogos de la hormona adrenocorticotropica y metodos relacionados.
PL1891446T3 (pl) 2005-06-14 2013-08-30 Cellzome Gmbh Sposób identyfikacji nowych związków oddziałujących z enzymami
US8242058B2 (en) 2006-07-21 2012-08-14 Wisconsin Alumni Research Foundation Reagents and methods for appending functional groups to proteins
JP2010229093A (ja) 2009-03-27 2010-10-14 Banyu Pharmaceut Co Ltd 新規ＣｈｅｍｅｒｉｎＲアゴニスト
GB0914110D0 (en) 2009-08-12 2009-09-16 Medical Res Council Peptide libraries
WO2011034887A2 (en) 2009-09-15 2011-03-24 The Brigham And Women's Hospital, Inc. A method for treating neuropathic pain
AU2011213631B2 (en) 2010-02-08 2015-05-14 Board Of Regents Of The University Of Nebraska Biomineral and metal binding liposomes, their synthesis, and methods of use thereof
US8883177B2 (en) 2011-06-28 2014-11-11 Nian Wu Pharmaceutical compositions for parenteral administration
HK1202064A1 (en) * 2011-10-13 2015-09-18 托马斯．盖德克 Topical formulations of chemerin c15 peptides for the treatment of dermatological conditions
WO2014168721A2 (en) 2013-04-12 2014-10-16 Tufts Medical Center Methods and systems for designing and/or characterizing soluble lipidated ligand agents
EP3405208B1 (en) 2016-01-22 2020-04-29 Tufts Medical Center, Inc. Compounds and methods for treating inflammation

Also Published As

Publication number Publication date
AU2017210118B2 (en) 2023-05-04
JP7432028B2 (ja) 2024-02-15
US20240325486A1 (en) 2024-10-03
US20190022168A1 (en) 2019-01-24
JP2021169531A (ja) 2021-10-28
JP2019507182A (ja) 2019-03-14
US11197906B2 (en) 2021-12-14
US12053501B2 (en) 2024-08-06
JP2023059999A (ja) 2023-04-27
US20220054581A1 (en) 2022-02-24
AU2017210118A1 (en) 2018-08-09
EP3405208B1 (en) 2020-04-29
EP3405208A1 (en) 2018-11-28
ES2805037T3 (es) 2021-02-10
CA3012190A1 (en) 2017-07-27
WO2017127827A1 (en) 2017-07-27

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