JP6921101B2 - プロテインキナーゼ阻害剤及びその調製方法と医薬用途 - Google Patents
プロテインキナーゼ阻害剤及びその調製方法と医薬用途 Download PDFInfo
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- JP6921101B2 JP6921101B2 JP2018546737A JP2018546737A JP6921101B2 JP 6921101 B2 JP6921101 B2 JP 6921101B2 JP 2018546737 A JP2018546737 A JP 2018546737A JP 2018546737 A JP2018546737 A JP 2018546737A JP 6921101 B2 JP6921101 B2 JP 6921101B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
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- Y02P20/50—Improvements relating to the production of bulk chemicals
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Landscapes
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- Nitrogen Condensed Heterocyclic Rings (AREA)
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| JP2021514359A (ja) | 2018-02-15 | 2021-06-10 | ニューベイション・バイオ・インコーポレイテッドＮｕｖａｔｉｏｎ Ｂｉｏ Ｉｎｃ． | キナーゼ阻害剤としての複素環式化合物 |
| WO2019170055A1 (zh) * | 2018-03-05 | 2019-09-12 | 上海海和药物研究开发有限公司 | 具有cdk4/6激酶抑制活性的化合物、其药用组合物和用途 |
| US20220079944A1 (en) * | 2019-01-29 | 2022-03-17 | Beta Pharma, Inc. | 2h-indazole derivatives as therapeutic agents for brain cancers and brain metastases |
| WO2020253865A1 (zh) | 2019-06-21 | 2020-12-24 | 甘李药业股份有限公司 | Cdk4/6抑制剂、及其盐和中间体的制备方法 |
| AR119184A1 (es) * | 2019-06-21 | 2021-12-01 | Gan & Lee Pharmaceuticals | Sales de un compuesto, formas cristalinas de las sales y método de preparación y uso de las mismas |
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| US11685744B2 (en) * | 2020-09-21 | 2023-06-27 | Prelude Therapeutics Incorporated | CDK inhibitors and their use as pharmaceuticals |
| CA3205652A1 (en) | 2020-12-18 | 2022-06-23 | Prelude Therapeutics Incorporated | Cdk inhibitors and their use as pharmaceuticals |
| CN112390793B (zh) * | 2021-01-19 | 2021-04-27 | 中国药科大学 | Cdk6/dyrk2双靶点抑制剂及其制备方法和应用 |
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| US20250332167A1 (en) * | 2021-05-17 | 2025-10-30 | Gan & Lee Pharmaceuticals Co., Ltd. | Pharmaceutical use of cdk 4/6 inhibitor |
| CN118119393A (zh) * | 2021-09-14 | 2024-05-31 | 甘李药业股份有限公司 | 一种cdk4/6抑制剂的医药用途 |
| WO2023116862A1 (zh) * | 2021-12-24 | 2023-06-29 | 江苏恒瑞医药股份有限公司 | 氢化吲哚类化合物、其制备方法及其在医药上的应用 |
| CN115093397B (zh) * | 2022-06-07 | 2023-09-05 | 自贡市第三人民医院 | 一种用于治疗肿瘤的化合物、合成方法及应用 |
| WO2024051717A1 (zh) * | 2022-09-08 | 2024-03-14 | 上海深势唯思科技有限责任公司 | 作为plk1抑制剂的化合物及其制备方法和用途 |
| CN119790049A (zh) * | 2022-09-30 | 2025-04-08 | 楚浦创制（武汉）医药科技有限公司 | 2-氨基嘧啶类化合物及其应用、药用组合物 |
| CN121270553A (zh) * | 2025-10-31 | 2026-01-06 | 广西医科大学第二附属医院(广西医科大学第二临床医学院) | 一种抗肿瘤化合物、抗肿瘤制剂及其制备方法 |
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| US20070117818A1 (en) | 2004-02-04 | 2007-05-24 | Masaichi Hasegawa | Pyrimidinone compounds useful as kinase inhibitors |
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| WO2009017838A2 (en) * | 2007-08-01 | 2009-02-05 | Exelixis, Inc. | Combinations of jak-2 inhibitors and other agents |
| HUE030912T2 (en) | 2008-02-15 | 2017-06-28 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2021138737A (ja) * | 2015-11-30 | 2021-09-16 | 甘李薬業股▲フン▼有限公司Gan&Lee Pharmaceuticals | プロテインキナーゼ阻害剤及びその調製方法と医薬用途 |
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